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Journal of Neural Transmission

, Volume 115, Issue 8, pp 1199–1211 | Cite as

Auditory processing of sine tones before, during and after ECT in depressed patients by fMRI

  • Martin Christ
  • Nikolaus Michael
  • Hermina Hihn
  • Anne Schüttke
  • Carsten Konrad
  • Bernhard T. Baune
  • Andreas Jansen
  • Bettina Pfleiderer
Biological Psychiatry - Original Article

Abstract

Our goal was to assess treatment effects of electroconvulsive therapy (ECT) on acoustic processing in major depression. We hypothesized that (1) depression is related to functional alterations in auditory networks, and that (2) pre-treatment alterations in auditory networks are reversible through treatment with ECT. Acoustic perception of 20 severely depressed and 20 age and gender matched healthy controls was investigated by 3 T functional magnetic resonance imaging employing repeated stimulation by sine tones. Prior to ECT, depressed patients presented a multimodal recruitment of additional brain areas including regions of the secondary visual system (cuneus, lingualis) and the medial frontal cortex. During ECT, signal intensities were reduced compared to pre-ECT values and controls. Activation of several regions increased after ECT. Our data suggest that depression is accompanied by cortical dysfunction including impaired auditory processing of non-speech stimuli. This might be based on overall alterations of brain metabolism indicating functional impairment.

Keywords

Depression fMRI Auditory processing Tones ECT 

Notes

Acknowledgments

This work was supported by an “Innovative Medical Research (IMF)” grant (Mi220229) from the Medical Faculty at the University of Münster, FRG. C. K. and A. J. were supported by the Interdisciplinary Center for Clinical Research (IZKF) of the University of Münster.

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Martin Christ
    • 1
    • 2
  • Nikolaus Michael
    • 2
    • 3
  • Hermina Hihn
    • 1
  • Anne Schüttke
    • 1
  • Carsten Konrad
    • 2
    • 4
  • Bernhard T. Baune
    • 2
    • 6
  • Andreas Jansen
    • 4
    • 5
  • Bettina Pfleiderer
    • 1
  1. 1.Department of Clinical RadiologyUniversity of MünsterMünsterGermany
  2. 2.Department of Psychiatry and PsychotherapyUniversity of MünsterMünsterGermany
  3. 3.Department of Psychiatry IIIEv. Stiftung TannenhofRemscheidGermany
  4. 4.Interdisciplinary Center for Clinical Research (IZKF)University of MünsterMünsterGermany
  5. 5.Department of NeurologyUniversity of MünsterMünsterGermany
  6. 6.Department of PsychiatryJames Cook UniversityBrisbaneAustralia

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