Auditory processing of sine tones before, during and after ECT in depressed patients by fMRI
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Our goal was to assess treatment effects of electroconvulsive therapy (ECT) on acoustic processing in major depression. We hypothesized that (1) depression is related to functional alterations in auditory networks, and that (2) pre-treatment alterations in auditory networks are reversible through treatment with ECT. Acoustic perception of 20 severely depressed and 20 age and gender matched healthy controls was investigated by 3 T functional magnetic resonance imaging employing repeated stimulation by sine tones. Prior to ECT, depressed patients presented a multimodal recruitment of additional brain areas including regions of the secondary visual system (cuneus, lingualis) and the medial frontal cortex. During ECT, signal intensities were reduced compared to pre-ECT values and controls. Activation of several regions increased after ECT. Our data suggest that depression is accompanied by cortical dysfunction including impaired auditory processing of non-speech stimuli. This might be based on overall alterations of brain metabolism indicating functional impairment.
KeywordsDepression fMRI Auditory processing Tones ECT
This work was supported by an “Innovative Medical Research (IMF)” grant (Mi220229) from the Medical Faculty at the University of Münster, FRG. C. K. and A. J. were supported by the Interdisciplinary Center for Clinical Research (IZKF) of the University of Münster.
- Bernal B, Altmann NR (2001) Auditory functional MR imaging. Am J Roentgenol 176:1009–1015Google Scholar
- Fitzgerald PB, Srithiran A, Benitez J et al (2007) An fMRI study of prefrontal brain activation during multiple tasks in patients with major depressive disorder. Hum Brain Mapp [Epub ahead of print]Google Scholar
- Ghaziuddin N, Laughrin D, Giordani BJCAP (2000) Cognitive side effects of electroconvulsive therapy in adolescents. J Child Adolesc Psychopharmacol 10:289–276Google Scholar
- Guy W (1976) ECDEU assessment manual for psychopharmacology. US Government Printing Office, Washington DCGoogle Scholar
- Hiller W, Zaudig M, Mombour W (2000) Internationale Diagnosen Checklisten (IDCL) für DSM-IV (International diagnostic checklists for DSM IV). Hogrefe Verlag, GöttingenGoogle Scholar
- Talairach J, Tournoux P (1988) Co-planar stereotaxic atlas of the human brain. 3-Dimensional proportional system: an approach to cerebral imaging. Thieme, New YorkGoogle Scholar