Journal of Neural Transmission

, Volume 115, Issue 7, pp 959–971 | Cite as

Reversal of the expression pattern of Aldolase C mRNA in Purkinje cells and Ube 1x mRNA in Golgi cells by a dopamine D1 receptor agonist injections in the methamphetamine sensitized-rat cerebellum

  • Mitsuko Hamamura
  • Naotsugu Hirata
  • Kazuhiko Sawada
  • Takahide Shuto
  • Takao Shimazoe
  • Yoshihiro Terada
  • Yasuyuki Fukumaki
Basic Neurosciences, Genetics and Immunology - Original Article


The cerebellum has a parasagittal modular structure, in which Zebrin (Aldolase) positive and negative bands expressed in Purkinje cell layers alternate, and is involved in amphetamine psychosis. Administration of SKF38393, a D1 receptor agonist, reversed the behavioral sensitization of methamphetamine. In the vermis, there were the binding sites of SKF38393. In methamphetamine-sensitized rats the expression of the Aldolase mRNA positive bands move laterally in the rat vermis. We provide here the evidence that the D1 agonist injections also reversed the expression pattern of both the Aldolase mRNA in Purkinje cells and Ube (ubiquitin activating enzyme) 1x mRNA in Golgi interneurons of the sensitized rats. Thus the reverse changes in gene expression pattern in the vermis may be involved in the mechanisms of the behavioral plasticity and suggests the new treatment of drug abuse.


Methamphetamine Dopamine agonists In situ hybridization Interneuron Neuronal plasticity 


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Mitsuko Hamamura
    • 1
    • 2
  • Naotsugu Hirata
    • 2
  • Kazuhiko Sawada
    • 4
  • Takahide Shuto
    • 3
  • Takao Shimazoe
    • 3
  • Yoshihiro Terada
    • 1
  • Yasuyuki Fukumaki
    • 2
  1. 1.Department of Fixed Prosthetics, Graduate School of Dental SciencesKyushu UniversityFukuokaJapan
  2. 2.Division of Disease Genes, Research Center for Genetic Information, Institute of Bio-RegulationKyushu UniversityFukuokaJapan
  3. 3.Department of Pharmacology, Graduate School of Pharmaceutical SciencesKyushu UniversityFukuokaJapan
  4. 4.Department of Anatomy and Developmental NeurobiologyUniversity of Tokushima Graduate School Institute of Health BiosciencesTokushimaJapan

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