Adrenergic α2A receptor gene and response to methylphenidate in attention-deficit/hyperactivity disorder-predominantly inattentive type
- 171 Downloads
An association between ADRA2A −1291 C > G polymorphism and response to methylphenidate in inattentive symptoms was previously suggested in children with ADHD. No investigation specifically assessed this association in ADHD–inattentive type (ADHD-I). In this naturalistic pharmacogenetic study, 59 subjects with ADHD-I from a non-referred sample were treated with short-acting methylphenidate and genotyped for ADRA2A −1291 C > G polymorphism. The primary outcome measure was the inattentive subscale of the SNAP-IV applied by a child psychiatrist blinded to genotype at baseline and first month of treatment. Children and adolescents with the G allele showed significantly lower inattentive scores with MPH treatment at the first month of treatment than subjects without the G allele (n = 59; F = 6.14; p = 0.016). We extended to ADHD-I previous findings suggesting the influence of the G allele at the ADRA2A −1291 C > G polymorphism on the improvement of inattentive symptoms with methylphenidate in children with all ADHD subtypes.
Unable to display preview. Download preview PDF.
- Friedel, S, Saar, K, Sauer, S, Dempfle, A, Walitza, S, Renner, T, Romanos, M, Freitag, C, Seitz, C, Palmason, H, Scherag, A, Windemuth-Kieselbach, C, Schimmelmann, BG, Wewetzer, C, Meyer, J, Warnke, A, Lesch, KP, Reinhardt, R, Herpertz-Dahlmann, B, Linder, M, Hinney, A, Remschmidt, H, Schafer, H, Konrad, K, Hubner, N, Hebebrand, J 2007Association and linkage of allelic variants of the dopamine transporter gene in ADHDMol Psychiatry1292333OctPubMedCrossRefGoogle Scholar
- Hebebrand, J, Dempfle, A, Saar, K, Thiele, H, Herpertz-Dahlmann, B, Linder, M, Kiefl, H, Remschmidt, H, Hemminger, U, Warnke, A, Knolker, U, Heiser, P, Friedel, S, Hinney, A, Schafer, H, Nurnberg, P, Konrad, K 2006A genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairsMol Psychiatry11196205FebPubMedCrossRefGoogle Scholar
- Kurth, JH 2000Pharmacogenomics: a genetic tool for identifying patients at riskDrug Inform J34223227Google Scholar
- Polanczyk, G, Zeni, C, Genro, J, Guimarães, AP, Roman, T, Hutz, MH, Rohde, LA 2007bAssociation of the adrenergic alpha2A receptor gene with methylphenidate improvement of inattentive symptoms in children and adolescents with attention-deficit/hyperactivity disorderArch Gen Psychiatry64218224CrossRefGoogle Scholar
- Schmitz, M, Denardin, D, Silva, TL, Pianca, T, Hutz, M, Faraone, S, Rohde, LA 2006bSmoking during pregnancy and ADHD inattentive type: a case-control studyJ Am Acad Child Adolesc Psychiatry4513381345Google Scholar
- Swanson, JM, Kraemer, HC, Hinshaw, SP, Arnold, LE, Conners, CK, Abikoff, HB, Clevenger, W, Davies, M, Elliott, GR, Greenhill, LL, Hechtman, L, Hoza, B, Jensen, PS, March, JS, Newcorn, JH, Owens, EB, Pelham, WE, Schiller, E, Severe, JB, Simpson, S, Vitiello, B, Wells, K, Wigal, T, Wu, M 2001Clinical relevance of the primary findings of the MTA: success rates based on severity of ADHD and ODD symptoms at the end of treatmentJ Am Acad Child Adolesc Psychiatry40168179PubMedCrossRefGoogle Scholar
- Wechsler D: WISC III/Manual (1991) The psychological corporation. New York, NYGoogle Scholar