Journal of Neural Transmission

, Volume 115, Issue 2, pp 279–285 | Cite as

Very low frequency EEG oscillations and the resting brain in young adults: a preliminary study of localisation, stability and association with symptoms of inattention

  • S. Helps
  • C. James
  • S. Debener
  • A. Karl
  • E. J. S. Sonuga-Barke
Article

Summary.

Background. Spontaneous very low frequency oscillations (VLFO: <0.2 Hz) in functional magnetic-resonance imaging are proposed to identify a default-mode network of resting brain activity. Activity in this network has been related to lapses of attention during goal-directed tasks and may provide a basis for ADHD. This study assessed the relation between scalp-recorded EEG VLFO at rest and ADHD.

Methods. 13 young adults with high- and 11 with low self-ratings of ADHD participated. Direct current EEG was recorded during a five minute rest session and was retested after approximately 1 week.

Results. A consistent and temporally stable pattern of VLFOs was observed across specific scalp regions in low-ADHD participants. High-ADHD participants had less VLFO power across these locations, especially where inattention self-ratings were high. Inattention was not related to VLFO power in other locations.

Discussion. Initial evidence is provided for a pattern of VLFOs at rest which is associated with inattention symptoms.

Keywords: Low frequency oscillations; direct current EEG; resting state; default mode; young adults; attention deficit/hyperactivity disorder; spontaneous neuronal activity 

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References

  1. Banaschewski, T, Brandeis, D 2007Annotation: what electrical brain activity tells us about brain function that other techniques cannot tell us – a child psychiatric perspectiveJ Child Psychol Psychiatry48415435PubMedCrossRefGoogle Scholar
  2. Barkley, R 1997Behavioural inhibition, sustained attention and executive function: constructing a unified theory of ADHDPsychol Bull1216594PubMedCrossRefGoogle Scholar
  3. Barkley, RA, Murphy, KR 1998Attention-deficit hyperactivity disorder: a clinical workbook2Guildford PressNew YorkGoogle Scholar
  4. Buzsaki, G, Draguhn, A 2004Neuronal oscillations in cortical networksScience30419261929PubMedCrossRefGoogle Scholar
  5. Castellanos FX, Margulies D, Kelly C, Uddin L, Ghaffari M, Kirsch A et al (2007) Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder. Biol Psychiary, (in press)Google Scholar
  6. Castellanos, FX, Sonuga-Barke, EJS, Scheres, A, DiMartino, A, Hyde, C, Walters, JR 2005Varieties of attention-deficit/hyperactivity disorder-related intra-individual variabilityBiol Psychiatry5714161423PubMedCrossRefGoogle Scholar
  7. Cohen, J 1992A power primerPsychol Bull112155159CrossRefGoogle Scholar
  8. Collett, BR, Ohan, JL, Myers, KM 2003Ten-year review of rating scales. V: scales assessing attention-deficit/hyperactivity disorderJ Am Acad Child Adolesc Psychiatry4210151037PubMedCrossRefGoogle Scholar
  9. De Luca, M, Beckmann, CF, De Stefano, N, Matthews, PM, Smith, SM 2006fMRI resting state networks define distinct modes of long-distance interactions in the human brainNeuroImage2913591367PubMedCrossRefGoogle Scholar
  10. Debener, S, Makeig, S, Delorme, A, Engel, AK 2005aWhat is novel in the novelty oddball paradigm? Functional significance of the novelty P3 event-related potential as revealed by independent component analysisCogn Brain Res22309321CrossRefGoogle Scholar
  11. Debener, S, Ullsperger, M, Siegel, M, Fiehler, K, von Cramon, DY, Engel, AK 2005bTrial-by-trial coupling of concurrent electroencephalogram and functional magnetic resonance imaging identifies the dynamics of performance monitoringJ Neurosci251173011737CrossRefGoogle Scholar
  12. Debener, S, Ullsperger, M, Siegel, M, Engel, AK 2006Single-trial EEG-fMRI reveals the dynamics of cognitive functionTrends Cogn Sci10558563PubMedCrossRefGoogle Scholar
  13. Drummond, SPA, Bischoff-Grethe, A, Dinges, DF, Ayalon, L, Mednick, SC, Meloy, MJ 2005The neural basis of the psychomotor vigilance taskSleep2810591068PubMedGoogle Scholar
  14. Fransson, P 2005Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesisHum Brain Mapp261529PubMedCrossRefGoogle Scholar
  15. Gasser, T, Bacher, P, Mocks, J 1982Transformations towards the normal-distribution of broad-band spectral parameters of the EEGElectroencephalogr Clin Neurophysiol53119124PubMedCrossRefGoogle Scholar
  16. James, CJ, Hesse, CW 2005Independent component analysis for biomedical signalsPhysiol Meas26R15R39PubMedCrossRefGoogle Scholar
  17. Makeig, S, Debener, S, Onton, J, Delorme, A 2004Mining event-related brain dynamicsTrends Cogn Sci8204210PubMedCrossRefGoogle Scholar
  18. Miller, JW, Kim, W, Holmes, MD, Vanhatalo, S 2007Ictal localization by source analysis of infraslow activity in DC-coupled scalp EEG recordingsNeuroImage35583597PubMedCrossRefGoogle Scholar
  19. Penttonen, M, Buzsaki, G 2003Natural logarithmic relationship between brain oscillatorsThal Rel Sys2145152Google Scholar
  20. Raichle, ME, MacLeod, AM, Snyder, AZ, Powers, WJ, Gusnard, DA, Shulman, GL 2001A default mode of brain functionProc Natl Acad Sci USA98676682PubMedCrossRefGoogle Scholar
  21. Sonuga-Barke E (2007) Modelling heterogeneity in the pathophysiology of ADHD. In: 1st International Congress on ADHD, pp XLVIIIGoogle Scholar
  22. Sonuga-Barke, EJ, Castellanos, FX 2007Spontaneous attentional fluctuations in impaired states and pathological conditions: a neurobiological hypothesisNeurosci Biobehav Rev31977986PubMedCrossRefGoogle Scholar
  23. Sonuga-Barke, EJS 2002Psychological heterogeneity in AD/HD – a dual pathway model of behaviour and cognitionBehav Brain Res1302936PubMedCrossRefGoogle Scholar
  24. Tian, LX, Jiang, TZ, Wang, YF, Zang, YF, He, Y, Liang, M,  et al. 2006Altered resting-state functional connectivity patterns of anterior cingulate cortex in adolescents with attention deficit hyperactivity disorderNeurosci Lett4003943PubMedCrossRefGoogle Scholar
  25. Vanhatalo, S, Holmes, MD, Tallgren, P, Voipio, J, Kaila, K, Miller, JW 2003Very slow EEG responses lateralize temporal lobe seizures – an evaluation of non-invasive DGEEGNeurology6010981104PubMedGoogle Scholar
  26. Weissman, DH, Roberts, KC, Visscher, KM, Woldorff, MG 2006The neural bases of momentary lapses in attentionNat Neurosci9971978PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • S. Helps
    • 1
  • C. James
    • 2
  • S. Debener
    • 3
  • A. Karl
    • 1
  • E. J. S. Sonuga-Barke
    • 1
    • 4
    • 5
  1. 1.School of PsychologyUniversity of SouthamptonSouthamptonUK
  2. 2.Institute of Sound and Vibration ResearchUniversity of SouthamptonSouthamptonUK
  3. 3.MRC Institute of Hearing ResearchUniversity of SouthamptonSouthamptonUK
  4. 4.Child Study CentreNew York UniversityNew YorkUSA
  5. 5.Social, Genetic, Developmental Psychiatry Centre, Institute of PsychiatryLondonUK

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