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Journal of Neural Transmission

, Volume 114, Issue 11, pp 1425–1431 | Cite as

Kainate receptor-mediated presynaptic inhibition converges with presynaptic inhibition mediated by Group II mGluRs and long-term depression at the hippocampal mossy fiber-CA3 synapse

  • J. V. Negrete-Díaz
  • T. S. Sihra
  • J. M. Delgado-García
  • A. Rodríguez-Moreno
Article

Summary

Kainate receptors (KARs) effect depression of glutamate release at hippocampal mossy fiber-CA3 (MF-CA3) synapses by a metabotropic action involving adenylyl cyclase (AC) inhibition, cAMP reduction, and diminished protein kinase A (PKA) activation. Using hippocampal slices, we show here that KAR activation interferes with the depression of glutamate release produced by Group II metabotropic glutamate receptor stimulation and low frequency stimulation (LFS)-induced long-term depression (LTD), also expressed through presynaptic AC/cAMP/PKA at MF-CA3 synapses. The mutual occlusion of depression mediated by presynaptic KARs, Group II mGluR and LFS-induced LTD suggests their mechanistic convergence at the MF-CA3 synapse and thus invokes KARs in synaptic plasticity manifest in LTD.

Keywords: Kainate receptors, metabotropic glutamate receptors, presynaptic inhibition, long-term depression, mossy fiber-CA3 synapse, protein kinase A 

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • J. V. Negrete-Díaz
    • 1
  • T. S. Sihra
    • 2
  • J. M. Delgado-García
    • 1
  • A. Rodríguez-Moreno
    • 1
  1. 1.División de NeurocienciasUniversidad Pablo de OlavideSevilleSpain
  2. 2.Department of PharmacologyUniversity College LondonLondonUK

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