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Journal of Neural Transmission

, Volume 114, Issue 8, pp 1091–1095 | Cite as

Clozapine/olanzapine-induced recurrence or deterioration of binge eating-related eating disorders

  • S. Gebhardt
  • M. Haberhausen
  • J.-C. Krieg
  • H. Remschmidt
  • M. Heinzel-Gutenbrunner
  • J. Hebebrand
  • F. M. Theisen
Article

Summary

Objective. To explore the association between eating disorders (EDs) prior to the use of clozapine/olanzapine (pre-clozapine/olanzapine EDs) and after initiation of these antipsychotics (post-clozapine/olanzapine EDs).

Method. Sixty-four consecutively admitted patients receiving clozapine/olanzapine were screened using the M-Composite International Diagnostic Interview (M-CIDI) to identify subjects with pre-clozapine/olanzapine EDs (DSM-IV criteria). We investigated post-clozapine/olanzapine EDs and binge eating behavior using the Questionnaire on Eating and Weight Patterns (QEWP) and used the Naranjo probability scale as objective causality assessment.

Results. Post-clozapine/olanzapine EDs were significantly more frequent in patients with pre-clozapine/olanzapine EDs (5 of 6) when compared to patients without pre-clozapine/olanzapine EDs (4 of 58) [χ2 = 26.29; df = 1; p < 0.001] [odds ratio (OR) 67.5; 95% CI: 6.3–25.8]. According to the Naranjo probability scale, recurrence or deterioration of EDs in patients with prior EDs was definitely (n = 1) or probably (n = 4) related to the intake of clozapine/olanzapine.

Conclusion. Clozapine/olanzapine may induce recurrence or deterioration of binge eating symptomatology or full-blown EDs in patients with prior EDs.

Keywords: Eating disorders, binge eating, antipsychotics, clozapine, olanzapine, recurrence, deterioration, schizophrenia 

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • S. Gebhardt
    • 1
    • 2
  • M. Haberhausen
    • 1
  • J.-C. Krieg
    • 2
  • H. Remschmidt
    • 1
  • M. Heinzel-Gutenbrunner
    • 1
    • 3
  • J. Hebebrand
    • 4
  • F. M. Theisen
    • 1
  1. 1.Clinical Research Group, Department of Child and Adolescent PsychiatryUniversity of MarburgMarburgGermany
  2. 2.Department of Psychiatry and PsychotherapyUniversity of MarburgMarburgGermany
  3. 3.Institute of Medical Biometry and EpidemiologyUniversity of MarburgMarburgGermany
  4. 4.Department of Child and Adolescent PsychiatryUniversity of Duisburg-EssenDuisburgGermany

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