Journal of Neural Transmission

, Volume 115, Issue 5, pp 731–735 | Cite as

Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson’s disease patients

  • Mariangela Pierantozzi
  • Maria Giuseppina Palmieri
  • Salvatore Galati
  • Paolo Stanzione
  • Antonella Peppe
  • Domenicantonio Tropepi
  • Livia Brusa
  • Antonio Pisani
  • Vincenzo Moschella
  • Maria Grazia Marciani
  • Paolo Mazzone
  • Alessandro Stefani
Parkinson's Disease and Allied Conditions - Short Communication

Abstract

Bilateral peduncolopontine nucleus (PPN) and subthalamic nucleus (STN) deep brain stimulation (DBS) was performed in six-advanced Parkinson’s disease (PD) patients. We report the effect of both PPN-DBS (25 Hz) and STN-DBS (185 Hz) on patient spinal reflex excitability by utilizing the soleus-Hoffman reflex (HR) threshold. Compared to controls (n = 9), patients showed an increase of HR-threshold, which was scarcely affected by levodopa, but significantly reduced by DBS. In particular, we found that PPN-DBS alone, or plus STN-DBS induced a complete recovery of HR-threshold up to control values. The HR-threshold changes, although do not allow to investigate the contribution of specific intraspinal pathways, suggest that PPN may play a key-role in modulating spinal excitability in PD possibly by improving the basal ganglia-brainstem descending system activity.

Keywords

Hoffman Roflex Pedunculopontine nucleus Deep brain stimulation Spinal cord excitability 

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Mariangela Pierantozzi
    • 1
    • 2
  • Maria Giuseppina Palmieri
    • 1
    • 2
  • Salvatore Galati
    • 1
    • 2
  • Paolo Stanzione
    • 1
    • 2
  • Antonella Peppe
    • 2
  • Domenicantonio Tropepi
    • 1
    • 2
  • Livia Brusa
    • 1
  • Antonio Pisani
    • 1
  • Vincenzo Moschella
    • 1
  • Maria Grazia Marciani
    • 1
    • 2
  • Paolo Mazzone
    • 3
  • Alessandro Stefani
    • 1
    • 2
  1. 1.Department of Neuroscience“Tor Vergata” UniversityRomeItaly
  2. 2.IRCCS Santa Lucia FoundationRomeItaly
  3. 3.Functional and Stereotactic NeurosurgeryOspedale CTORomeItaly

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