Orthostatic hypotension and attention in Parkinson’s disease with and without dementia Article First Online: 03 January 2007 Received: 25 August 2006 Accepted: 27 November 2006 DOI:
Cite this article as: Peralta, C., Stampfer-Kountchev, M., Karner, E. et al. J Neural Transm (2007) 114: 585. doi:10.1007/s00702-006-0615-2 Summary.
To compare frequency and degree of orthostatic hypotension (OH) in Parkinson’s disease (PD) and Parkinson’s disease with dementia (PDD) and its effect on attention and word fluency, blood pressure (BP) and heart rate changes during tilt were determined in 10 PD and 8 PDD patients. Attention and word fluency were evaluated in supine and tilted position using standard neuropsychological tests.
OH defined as systolic BP (SBP) drop of ≥20 mmHg and/or diastolic BP (DBP) drop of ≥10 mmHg was present in 5 PDD patients and in 2 PD patients. SBP drop was significantly greater in PDD than in PD patients (
P < 0.05). Whereas word fluency was unaffected by tilt in both patient groups, attention as assessed with the Test of Everyday Attention (TEA) deteriorated significantly in the PDD group, correlating with blood pressure response (ΔSBP and TEA-2, r = 0.828, P < 0.05; ΔDBP and TEA-2, r = 0.828, P < 0.05).
We conclude that OH is frequent in PDD and should be addressed therapeutically since it may exacerbate attentional dysfunction.
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