Journal of Neural Transmission

, Volume 114, Issue 5, pp 527–537 | Cite as

How a neuropsychiatric brain bank should be run: a consensus paper of Brainnet Europe II

  • A. Schmitt
  • M. Bauer
  • H. Heinsen
  • W. Feiden
  • The Consortium of Brainnet Europe II
  • P. Falkai
  • I. Alafuzoff
  • T. Arzberger
  • S. Al-Sarraj
  • J. E. Bell
  • N. Bogdanovic
  • W. Brück
  • H. Budka
  • I. Ferrer
  • G. Giaccone
  • G. G. Kovacs
  • D. Meyronet
  • M. Palkovits
  • P. Parchi
  • E. Patsouris
  • R. Ravid
  • R. Reynolds
  • P. Riederer
  • W. Roggendorf
  • A. Schwalber
  • D. Seilhean
  • H. Kretzschmar


The development of new molecular and neurobiological methods, computer-assisted quantification techniques and neurobiological investigation methods which can be applied to the human brain, all have evoked an increased demand for post-mortem tissue in research. Psychiatric disorders are considered to be of neurobiological origin. Thus far, however, the etiology and pathophysiology of schizophrenia, depression and dementias are not well understood at the cellular and molecular level. The following will outline the consensus of the working group for neuropsychiatric brain banking organized in the Brainnet Europe II, on ethical guidelines for brain banking, clinical diagnostic criteria, the minimal clinical data set of retrospectively analyzed cases as well as neuropathological standard investigations to perform stageing for neurodegenerative disorders in brain tissue. We will list regions of interest for assessments in psychiatric disorder, propose a dissection scheme and describe preservation and storage conditions of tissue. These guidelines may be of value for future implementations of additional neuropsychiatric brain banks world-wide.

Keywords: Brain bank, post-mortem, schizophrenia, depression, dementia, neuropathology 


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • A. Schmitt
    • 1
    • 2
  • M. Bauer
    • 3
  • H. Heinsen
    • 4
  • W. Feiden
    • 5
  • The Consortium of Brainnet Europe II
  • P. Falkai
    • 1
  • I. Alafuzoff
    • 6
  • T. Arzberger
    • 7
  • S. Al-Sarraj
    • 8
  • J. E. Bell
    • 9
  • N. Bogdanovic
    • 10
  • W. Brück
    • 11
  • H. Budka
    • 12
  • I. Ferrer
    • 13
  • G. Giaccone
    • 14
  • G. G. Kovacs
    • 15
  • D. Meyronet
    • 16
  • M. Palkovits
    • 17
  • P. Parchi
    • 18
  • E. Patsouris
    • 19
  • R. Ravid
    • 20
  • R. Reynolds
    • 21
  • P. Riederer
    • 22
  • W. Roggendorf
    • 23
  • A. Schwalber
    • 24
  • D. Seilhean
    • 25
  • H. Kretzschmar
    • 7
  1. 1.Department of PsychiatryUniversity of GöttingenGöttingenGermany
  2. 2.Central Institute of Mental HealthMannheimGermany
  3. 3.Department of NeuropathologyUniversity of LeipzigLeipzigGermany
  4. 4.Morphological Brain Research UnitUniversity of WürzburgWürzburgGermany
  5. 5.Department of NeuropathologyUniversity of SaarlandHomburgGermany
  6. 6.Department of Neuroscience and NeurologyUniversity of KuopioKuopioFinland
  7. 7.Institute of NeuropathologyLudwig Maximilians University MunichMunichGermany
  8. 8.King’s College LondonLondonUnited Kingdom
  9. 9.Institute of NeuropathologyUniversity of EdinburghEdinburghUnited Kingdom
  10. 10.Karolinska Institute, Neurotec, GeriatricHuddinge Brain Bank, NOVUMStockholmSweden
  11. 11.Department of NeuropathologyUniversity of GöttingenGöttingenGermany
  12. 12.Institute of NeurologyMedical University of ViennaWienAustria
  13. 13.Institute of Neuropathology, Hospital de BellvitgeUniversity of BarcelonaBarcelonaSpain
  14. 14.Division of Neuropathology and NeurologyNational Institute of Neurology Carlo BestaMilanoItaly
  15. 15.National Institute of Psychiatry and NeurologyBudapestHungary
  16. 16.Neuropathology, Department of PathologyNeurological HospitalCHU de LyonFrance
  17. 17.Human Brain Tissue Bank BudapestBudapestHungary
  18. 18.Department of Neurological ScienceUniversity of BolognaBolognaItaly
  19. 19.Department of PathologyNational and Capodistrian University of AthensAthensGreece
  20. 20.Netherlands Brain BankAmsterdamNetherlands
  21. 21.Imperial College of Technology and MedicineLondonUnited Kingdom
  22. 22.Institute of Clinical Neurochemistry and NPF-Center of Excellence Laboratories, Clinic for Psychiatry and PsychotherapyUniversity of WürzburgWürzburgGermany
  23. 23.Department of Neuropathology, Institute of PathologyUniversity of WürzburgWürzburgGermany
  24. 24.GABO:mi mbH & Co.KGMunichGermany
  25. 25.Laboratory of NeuropathologyUniversity Pierre et Marie CurieParisFrance

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