Advertisement

Journal of Neural Transmission

, Volume 114, Issue 4, pp 461–468 | Cite as

Interaction between TPH1 and GNB3 genotypes and electroconvulsive therapy in major depression

  • S. Anttila
  • K. Huuhka
  • M. Huuhka
  • R. Rontu
  • K. M. Mattila
  • E. Leinonen
  • T. Lehtimäki
Article

Summary

We studied the association between tryptophan hydroxylase 1 (TPH1) A218C and G-protein beta-3 subunit (GNB3) C825T polymorphisms and treatment response in electroconvulsive therapy (ECT). The sample consisted of 119 patients with major depressive disorder (MDD) and 398 controls. Neither TPH1 nor GNB3 polymorphisms are associated with treatment response. However, subjects carrying TPH1 CC genotype are more likely to belong to the patient sample than to the controls. In female subjects, T-allele of GNB3 polymorphism increases the risk of being a treatment-resistant patient with MDD. Moreover, in females the combination of TPH1 CC and GNB3 CT + TT genotype is associated with an increased risk of belonging to the patient group.

Keywords: TPH1, GNB3, polymorphism, major depression, electroconvulsive therapy 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Avissar, S 1999The role of G proteins in the psychobiology and treatment of affective disorders and their integration with the neurotransmitter hypothesisCurr Psychiatry Rep1148153PubMedGoogle Scholar
  2. Avissar, S, Nechamkin, Y, Roitman, G, Schreiber, G 1998Dynamics of ECT normalization of low G protein function and immunoreactivity in mononuclear leukocytes of patients with major depressionAm J Psychiatry155666671PubMedGoogle Scholar
  3. Bellivier, F, Chaste, P, Malafosse, A 2004Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysisAm J Med Genet124B8791CrossRefGoogle Scholar
  4. Bloch, Y, Ratzoni, G, Sobol, D, Mendlovic, S, Gal, G, Levkovitz, Y 2005Gender differences in electroconvulsive therapy: a retrospective chart reviewJ Affect Disord8499102PubMedCrossRefGoogle Scholar
  5. Bondy, B, Baghai, TC, Zill, P, Bottlender, R, Jaeger, M, Minov, C, Schule, C, Zwanzger, P, Rupprecht, R, Engel, RR 2002Combined action of the ACE D and the G-protein beta3 T-allele in major depression: a possible link to cardiovascular disease?Mol Psychiatry711201126PubMedCrossRefGoogle Scholar
  6. Christiansen L, Tan Q, Iachina M, Bathum L, Kruse TA, McGue M, Christensen K (2006) Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population. Biol Psychiatry June 23 [Epub ahead of print]Google Scholar
  7. Cohen, LS 2003Gender-specific considerations in the treatment of mood disorders in women across the life cycleJ Clin Psychiatry641829PubMedGoogle Scholar
  8. Cusin, C, Serretti, A, Lattuada, E, Lilli, R, Lorenzi, C, Mandelli, L, Pisati, E, Smeraldi, E 2001Influence of 5-HTTLPR and TPH variants on illness time course in mood disordersJ Psychiatr Res35217223PubMedCrossRefGoogle Scholar
  9. Eley, TC, Sugden, K, Corsico, A, Gregory, AM, Sham, P, McGuffin, P, Plomin, R, Craig, IW 2004Gene-environment interaction analysis of serotonin system markers with adolescent depressionMol Psychiatry9908915PubMedCrossRefGoogle Scholar
  10. Exton, MS, Artz, M, Siffert, W, Schedlowski, M 2003G protein beta3 subunit 825T allele is associated with depression in young, healthy subjectsNeuroreport14531533PubMedCrossRefGoogle Scholar
  11. Fisman, M, Rabheru, K, Hegele, RA, Sharma, V, Fisman, D, Doering, M, Appell, J 2001Apolipoprotein E polymorphism and response to electroconvulsive therapyJ ECT171114PubMedCrossRefGoogle Scholar
  12. Frisch, A, Postilnick, D, Rockah, R, Michaelovsky, E, Postilnick, S, Birman, E, Laor, N, Rauchverger, B, Kreinin, A, Poyurovsky, M, Schneidman, M, Modai, I, Weizman, R 1999Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathwaysMol Psychiatry4389392PubMedCrossRefGoogle Scholar
  13. Furlong, RA, Ho, L, Rubinsztein, JS, Walsh, C, Paykel, ES, Rubinsztein, DC 1998No association of the tryptophan hydroxylase gene with bipolar affective disorder, unipolar affective disorder, or suicidal behaviour in major affective disorderAm J Med Genet81245247PubMedCrossRefGoogle Scholar
  14. Gerdes, LU 2003The common polymorphism of apolipoprotein E: geographical aspects and new pathophysiological relationsClin Chem Lab Med41628631PubMedCrossRefGoogle Scholar
  15. Halbreich, U, Kahn, LS 2001Role of estrogen in the aetiology and treatment of mood disordersCNS Drugs15797817PubMedCrossRefGoogle Scholar
  16. Huuhka, M, Anttila, S, Leinonen, E, Huuhka, K, Rontu, R, Mattila, KM, Huhtala, H, Lehtimaki, T 2005The apolipoprotein E polymorphism is not associated with response to electroconvulsive therapy in major depressive disorderJ ECT21711PubMedCrossRefGoogle Scholar
  17. Ishihara, K, Sasa, M 2001Potentiation of 5-HT(3) receptor functions in the hippocampal CA1 region of rats following repeated electroconvulsive shock treatmentsNeurosci Lett3073740PubMedCrossRefGoogle Scholar
  18. Jonsson, EG, Goldman, D, Spurlock, G, Gustavsson, JP, Nielsen, DA, Linnoila, M, Owen, MJ, Sedvall, GC 1997Tryptophan hydroxylase and catechol-O-methyltransferase gene polymorphisms: relationships to monoamine metabolite concentrations in CSF of healthy volunteersEur Arch Psychiatr Clin Neurosci247297302CrossRefGoogle Scholar
  19. Joyce, PR, Mulder, RT, Luty, SE, McKenzie, JM, Miller, AL, Rogers, GR, Kennedy, MA 2003Age-dependent antidepressant pharmacogenomics: polymorphisms of the serotonin transporter and G protein beta3 subunit as predictors of response to fluoxetine and nortriptylineInt J Neuropsychopharmacol6339346PubMedCrossRefGoogle Scholar
  20. Kornstein, SG, Schneider, RK 2001Clinical features of treatment-resistant depressionJ Clin Psychiatry621825PubMedGoogle Scholar
  21. Koubi, D, Bezin, L, Cottet-Emard, JM, Gharib, A, Bobillier, P, Sarda, N 2001Regulation of expression and enzymatic activities of tyrosine and tryptophan hydroxylases in rat brain after acute electroconvulsive shockBrain Res905161170PubMedCrossRefGoogle Scholar
  22. Kunugi, H, Ishida, S, Kato, T, Sakai, T, Tatsumi, M, Hirose, T, Nanko, S 1999No evidence for an association of polymorphisms of the tryptophan hydroxylase gene with affective disorders or attempted suicide among Japanese patientsAm J Psychiatry156774776PubMedGoogle Scholar
  23. Kunugi, H, Kato, T, Fukuda, R, Tatsumi, M, Sakai, T, Nanko, S 2002Association study of C825T polymorphism of the G-protein b3 subunit gene with schizophrenia and mood disordersJ Neural Transm109213218PubMedCrossRefGoogle Scholar
  24. Lee, HJ, Cha, JH, Ham, BJ, Han, CS, Kim, YK, Lee, SH, Ryu, SH, Kang, RH, Choi, MJ, Lee, MS 2004Association between a G-protein beta3 subunit gene polymorphism and the symptomatology and treatment responses of major depressive disordersPharmacogenomics J42933PubMedCrossRefGoogle Scholar
  25. Lin, CN, Tsai, SJ, Hong, CJ 2001Association analysis of a functional G protein beta3 subunit gene polymorphism (C825T) in mood disordersNeuropsychobiology44118121PubMedCrossRefGoogle Scholar
  26. Lindeman, S, Hamalainen, J, Isometsa, E, Kaprio, J, Poikolainen, K, Heikkinen, M, Aro, H 2000The 12-month prevalence and risk factors for major depressive episode in Finland: representative sample of 5993 adultsActa Psychiatr Scand102178184PubMedCrossRefGoogle Scholar
  27. Livak, KJ 1999Allelic discrimination using fluorogenic probes and the 5′ nuclease assayGenet Anal14143149PubMedGoogle Scholar
  28. Mann, JJ, Malone, KM, Nielsen, DA, Goldman, D, Erdos, J, Gelernter, J 1997Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patientsAm J Psychiatry15414511453PubMedGoogle Scholar
  29. McGowan, S, Eastwood, SL, Mead, A, Burnet, PW, Smith, C, Flanigan, TP, Harrison, PJ 1996Hippocampal and cortical G protein (Gs alpha, G(o) alpha and Gi2 alpha) mRNA expression after electroconvulsive shock or lithium carbonate treatmentEur J Pharmacol306249255PubMedCrossRefGoogle Scholar
  30. McKinney, J, Knappskog, PM, Haavik, J 2005Different properties of the central and peripheral forms of human tryptophan hydroxylaseJ Neurochem92311320PubMedCrossRefGoogle Scholar
  31. Nielsen, DA, Jenkins, GL, Stefanisko, KM, Jefferson, KK, Goldman, D 1997Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7Brain Res Mol Brain Res45145148PubMedCrossRefGoogle Scholar
  32. Pagnin, D, de Queiroz, V, Pini, S, Cassano, GB 2004Efficacy of ECT in depression: a meta-analytic reviewJ ECT201320PubMedCrossRefGoogle Scholar
  33. Peters, EJ, Slager, SL, McGrath, PJ, Knowles, JA, Hamilton, SP 2004Investigation of serotonin-related genes in antidepressant responseMol Psychiatry9879889PubMedCrossRefGoogle Scholar
  34. Rosskopf, D, Koch, K, Habich, C, Geerdes, J, Ludwig, A, Wilhelms, S, Jakobs, KH, Siffert, W 2003Interaction of Gbeta3s, a splice variant of the G-protein Gbeta3, with Ggamma- and Galpha-proteinsCell Signal15479488PubMedCrossRefGoogle Scholar
  35. Serretti, A, Zanardi, R, Cusin, C, Rossini, D, Lorenzi, C, Smeraldi, E 2001aTryptophan hydroxylase gene associated with paroxetine antidepressant activityEur Neuropsychopharmacol11375380CrossRefGoogle Scholar
  36. Serretti, A, Zanardi, R, Rossini, D, Cusin, C, Lilli, R, Smeraldi, E 2001bInfluence of tryptophan hydroxylase and serotonin transporter genes on fluvoxamine antidepressant activityMol Psychiatry6586592CrossRefGoogle Scholar
  37. Serretti, A, Lilli, R, Lorenzi, C, Lattuada, E, Cusin, C, Smeraldi, E 2001cTryptophan hydroxylase gene and major psychosesPsychiatry Res1037986CrossRefGoogle Scholar
  38. Serretti, A, Cristina, S, Lilli, R, Cusin, C, Lattuada, E, Lorenzi, C, Corradi, B, Grieco, G, Costa, A, Santorelli, F, Barale, F, Nappi, G, Smeraldi, E 2002Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disordersAm J Med Genet114361369PubMedCrossRefGoogle Scholar
  39. Serretti, A, Lorenzi, C, Cusin, C, Zanardi, R, Lattuada, E, Rossini, D, Lilli, R, Pirovano, A, Catalano, M, Smeraldi, E 2003SSRIs antidepressant activity is influenced by G beta 3 variantsEur Neuropsychopharmacol13117122PubMedCrossRefGoogle Scholar
  40. Serretti, A, Cusin, C, Rossini, D, Artioli, P, Dotoli, D, Zanardi, R 2004aFurther evidence of a combined effect of SERTPR and TPH on SSRIs response in mood disordersAm J Med Genet B Neuropsychiatr Genet129B3640CrossRefGoogle Scholar
  41. Serretti, A, Zanardi, R, Franchini, L, Artioli, P, Dotoli, D, Pirovano, A, Smeraldi, E 2004bPharmacogenetics of selective serotonin reuptake inhibitor response: a 6-month follow-upPharmacogenetics14607613CrossRefGoogle Scholar
  42. Sloan, DM, Kornstein, SG 2003Gender differences in depression and response to antidepressant treatmentPsychiatr Clin North Am26581594PubMedCrossRefGoogle Scholar
  43. Stahl, SM 2001Sex and psychopharmacology: is natural estrogen a psychotropic drug in women?Arch Gen Psychiatry5537538CrossRefGoogle Scholar
  44. Stockmeier, CA 2003Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporterJ Psychiatr Res37357373PubMedCrossRefGoogle Scholar
  45. UK ECT Review Group2003Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysisLancet361799808CrossRefGoogle Scholar
  46. Wahlund, B, von Rosen, D 2003ECT of major depressed patients in relation to biological and clinical variables: A brief overviewNeuropsychopharmacology28S21S26PubMedCrossRefGoogle Scholar
  47. Yonkers, KA, Brawman-Mintzer, O 2002The pharmacologic treatment of depression: is gender a critical factor?J Clin Psychiatry63610615PubMedGoogle Scholar
  48. Yoshida, K, Naito, S, Takahashi, H, Sato, K, Ito, K, Kamata, M, Higuchi, H, Shimizu, T, Itoh, K, Inoue, K, Tezuka, T, Suzuki, T, Ohkubo, T, Sugawara, K, Otani, K 2002Monoamine oxidase: A gene polymorphism, tryptophan hydroxylase gene polymorphism and antidepressant response to fluvoxamine in Japanese patients with major depressive disorderProg Neuropsychopharmacol Biol Psychiatry2612791283PubMedCrossRefGoogle Scholar
  49. Zhang, X, Beaulieu, JM, Sotnikova, TD, Gainetdinov, RR, Caron, MG 2004Tryptophan hydroxylase-2 controls brain serotonin synthesisScience305217PubMedCrossRefGoogle Scholar
  50. Zill, P, Baghai, TC, Zwanzger, P, Schule, C, Minov, C, Riedel, M, Neumeier, K, Rupprecht, R, Bondy, B 2000Evidence for an association between a G-protein beta3-gene variant with depression and response to antidepressant treatmentNeuroreport1118931897PubMedCrossRefGoogle Scholar
  51. Zill, P, Buttner, A, Eisenmenger, W, Ackenheil, M, Bondy, B 2004Expression analysis of the tryptophan hydroxylase genes TPH1 and TPH2 in post mortem human brain samples. Twelfth World Congress of Psychiatric Genetics. Dublin, Ireland, 9–13, October, 2004. Abstract P15.11Am J Med Genet130B1180CrossRefGoogle Scholar
  52. Zimmerman, M, Chelminski, I, Posternak, M 2000A review of studies of the Montgomery-Asberg Depression Rating Scale in controls: implications for the definition of remission in treatment studies of depressionInt Clin Psychopharmacol1917CrossRefGoogle Scholar
  53. Zubenko, GS, Maher, B, Hughes, HB,3rd, Zubenko, WN, Stiffler, JS, Kaplan, BB, Marazita, ML 2003Genome-wide linkage survey for genetic loci that influence the development of depressive disorders in families with recurrent, early-onset, major depressionAm J Med Genet B Neuropsychiatr Genet123118PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • S. Anttila
    • 1
    • 2
  • K. Huuhka
    • 1
    • 3
  • M. Huuhka
    • 1
    • 3
  • R. Rontu
    • 1
    • 2
  • K. M. Mattila
    • 1
    • 2
  • E. Leinonen
    • 1
    • 3
  • T. Lehtimäki
    • 1
    • 2
  1. 1.Medical SchoolUniversity of TampereTampereFinland
  2. 2.Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory MedicineTampere University HospitalTampereFinland
  3. 3.Department of PsychiatryTampere University HospitalPitkäniemiFinland

Personalised recommendations