Journal of Neural Transmission

, Volume 114, Issue 3, pp 331–335 | Cite as

Striatal FP-CIT uptake differs in the subtypes of early Parkinson’s disease

  • J. Spiegel
  • D. Hellwig
  • S. Samnick
  • W. Jost
  • M.-O. Möllers
  • K. Fassbender
  • C.-M. Kirsch
  • U. Dillmann
Article

Summary.

In idiopathic Parkinson’s disease (PD), a tremor-dominant type (TDT), an akinetic-rigid type (ART), and a mixed type (MT) are distinguished. We compared cerebral [I-123]FP-CIT SPECT in the PD subtypes (67 patients Hoehn and Yahr stage 1:26 with ART, 19 with MT, 22 with TDT). We measured the ratios putamen/occipital lobe binding and caudate nucleus/occipital lobe binding. Parkinsonian motor symptoms were quantified by UPDRS motor scale. In both putamen and caudate nucleus contralateral to the clinically affected body side TDT patients showed a significantly higher FP-CIT uptake than ART or MT patients (ANOVA; p<0.01). Contralateral putamen and caudate nucleus FP-CIT uptake correlated significantly with severity of rigidity (p<0.01) and hypokinesia (p<0.01) but not with severity of resting or postural tremor (p>0.05). The missing correlation between striatal FP-CIT uptake and tremor suggests, that further systems besides the nigrostriatal dopaminergic system may contribute to generation of parkinsonian tremor.

Keywords: Parkinson’s disease, FP-CIT SPECT 

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • J. Spiegel
    • 1
  • D. Hellwig
    • 2
  • S. Samnick
    • 2
  • W. Jost
    • 3
  • M.-O. Möllers
    • 2
  • K. Fassbender
    • 1
  • C.-M. Kirsch
    • 2
  • U. Dillmann
    • 1
  1. 1.Department of NeurologySaarland UniversityHomburg/SaarGermany
  2. 2.Department of Nuclear MedicineSaarland UniversityHomburg/SaarGermany
  3. 3.Department of NeurologyDeutsche Klinik fur DiagnostikWiesbadenGermany

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