Journal of Neural Transmission

, Volume 114, Issue 2, pp 285–288 | Cite as

Contralateral prefrontal projections in gerbils mature abnormally after early methamphetamine trauma and isolated rearing

  • A. V. Witte
  • F. Bagorda
  • G. Teuchert-Noodt
  • K. Lehmann
Short Communication

Summary.

As previously shown, a miswiring of ipsilateral prefrontal projections after methamphetamine (MA) intoxication and/or isolated rearing (IR) may serve as a model of so-called “dysconnection” in human schizophrenia. We here find that deep prefrontal projections to contralateral targets were drastically reduced by both MA and IR alone, but remained equally dense if both impairments cumulated. Projections from superficial layers were not altered by MA and/or IR. These findings confirm that the normal intercortical integration of information is compromised in this animal model of schizophrenia.

Keywords: Methamphetamine, prefrontal cortex, dysconnection, laterality, cortico-cortical projections 

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • A. V. Witte
    • 1
  • F. Bagorda
    • 1
  • G. Teuchert-Noodt
    • 1
  • K. Lehmann
    • 2
  1. 1.Department of Neuroanatomy, Faculty of BiologyUniversity of BielefeldGermany
  2. 2.Department of NeurobiologyInstitute of General ZoologyJenaGermany

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