Journal of Neural Transmission

, Volume 113, Issue 12, pp 1921–1925

Rgs 2 gene polymorphisms as modulators of anxiety in humans?

  • A. Leygraf
  • C. Hohoff
  • C. Freitag
  • S. A. G. Willis-Owen
  • P. Krakowitzky
  • J. Fritze
  • P. Franke
  • B. Bandelow
  • R. Fimmers
  • J. Flint
  • J. Deckert
Article

Summary.

Rgs2 (regulator of G-protein signalling 2) gene recently was reported as a quantitative trait gene for anxious behaviour in mice and male Rgs2 knockout mice have been shown to be more anxious than wildtype mice. Therefore we investigated four non-coding single nucleotide polymorphisms in a sample of 173 patients with panic disorder and 173 matched controls of German descent. At the genotype level all four SNPs were associated with panic disorder (p = 0.02–0.05). At the haplotype level the strongest association was observed for a haplotype containing SNP3 and SNP 4 (subgroup men and men with agoraphobia: p = 0.01 and 0.03). This points towards a functional polymorphism at the 3′ end of the gene. Our results support the hypothesis that variations of the Rgs2 gene play a role also for the development of anxiety in humans.

Keywords: Rgs2, chromosom 1q31, panic disorder, linkage disequilibrium, polymorphisms, case-control-study 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • A. Leygraf
    • 1
  • C. Hohoff
    • 1
  • C. Freitag
    • 2
  • S. A. G. Willis-Owen
    • 3
  • P. Krakowitzky
    • 4
  • J. Fritze
    • 5
  • P. Franke
    • 6
  • B. Bandelow
    • 7
  • R. Fimmers
    • 8
  • J. Flint
    • 3
  • J. Deckert
    • 1
  1. 1.Laboratory of Molecular Psychiatry, Department of PsychiatryUniversity of MünsterMünsterGermany
  2. 2.Department of Child & Adolescent PsychiatryUniversity of SaarlandSaarlandGermany
  3. 3.Wellcome Trust Centre for Human GeneticsUniversity of OxfordOxfordUK
  4. 4.Institute of Transfusion MedicineUniversity of MünsterMünsterGermany
  5. 5.Department of PsychiatryUniversity of FrankfurtFrankfurtGermany
  6. 6.Department of PsychiatryUniversity of BonnBonnGermany
  7. 7.Department of PsychiatryUniversity of GötttingenGötttingenGermany
  8. 8.Institute for Medical Biometry, Informatics and EpidemiologyUniversity of BonnBonnGermany

Personalised recommendations