Journal of Neural Transmission

, Volume 112, Issue 11, pp 1479–1485

Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation

  • T. Canli
  • E. Congdon
  • L. Gutknecht
  • R. T. Constable
  • K. P. Lesch
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DOI: 10.1007/s00702-005-0391-4

Cite this article as:
Canli, T., Congdon, E., Gutknecht, L. et al. J Neural Transm (2005) 112: 1479. doi:10.1007/s00702-005-0391-4

Summary.

The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence.

Keywords: Tryptophan hydroxylase-2 gene, amygdala, functional imaging. 

Copyright information

© Springer-Verlag/Wien 2005

Authors and Affiliations

  • T. Canli
    • 1
    • 2
  • E. Congdon
    • 1
  • L. Gutknecht
    • 4
  • R. T. Constable
    • 3
  • K. P. Lesch
    • 4
  1. 1.Department of PsychologyStony Brook UniversityStony BrookUSA
  2. 2.Graduate Program in Genetics, Stony Brook UniversityStony BrookUSA
  3. 3.MRRC Yale UniversityNew HavenUSA
  4. 4.Molecular and Clinical Psychobiology, Department of Psychiatry and PsychotherapyUniversity of WürzburgWürzburgGermany

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