Journal of Neural Transmission

, Volume 113, Issue 9, pp 1253–1262 | Cite as

Association study of polymorphisms in LRP1, tau and 5-HTT genes and Alzheimer’s disease in a sample of Colombian patients

  • D. A. Forero
  • G. Arboleda
  • J. J. Yunis
  • R. Pardo
  • H. Arboleda
Article

Summary.

Analysis of genetic susceptibility factors for Alzheimer’s disease (AD) in populations with different genetic and environmental background may be useful to understand AD etiology. There are few genetic association studies of AD in Latin America. In the present work, we analyzed polymorphisms in 3 candidate genes; the LDL receptor related protein-1, the microtubule-associated protein Tau and the serotonin transporter genes in a sample of 106 Colombian AD patients and 97 control subjects. We did not find a significant allelic or genotypic association with any of the three polymorphisms analyzed using different statistical analysis, including a neural network model or different sample stratifications. To date, APOE polymorphisms are the only genetic risk factors identified for AD in the Colombian population. It may be factible that future combination of high-throughput genotyping platforms and multivariate analysis models may lead to the identification of other genetic susceptibility factors for AD in the Colombian population.

Keywords: Alzheimer’s disease, genetic association, Colombia. 

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References

  1. Arboleda, GH, Yunis, JJ, Pardo, R, Gomez, CM, Hedmont, D, Arango, G, Arboleda, H 2001Apolipoprotein E genotyping in a sample of Colombian patients with Alzheimer’s diseaseNeurosci Lett305135138PubMedCrossRefGoogle Scholar
  2. Assal, F, Alarcon, M, Solomon, EC, Masterman, D, Geschwind, DH, Cummings, JL 2004Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer diseaseArch Neurol6112491253PubMedCrossRefGoogle Scholar
  3. Baker, M, Graff-Radford, D, Wavrant DeVrieze, F, Graff-Radford, N, Petersen, RC, Kokmen, E, Boeve, B, Myllykangas, L, Polvikoski, T, Sulkava, R, Verkoniemmi, A, Tienari, P, Haltia, M, Hardy, J, Hutton, M, Perez-Tur, J 2000No association between TAU haplotype and Alzheimer’s disease in population or clinic based series or in familial diseaseNeurosci Lett285147149PubMedCrossRefGoogle Scholar
  4. Baum, L, Chen, L, Ng, HK, Chan, YS, Mak, YT, Woo, J, Chiu, HF, Pang, CP 1998Low density lipoprotein receptor related protein gene exon 3 polymorphism association with Alzheimer’s disease in ChineseNeurosci Lett2473336PubMedCrossRefGoogle Scholar
  5. Beffert, U, Arguin, C, Poirier, J 1999The polymorphism in exon 3 of the low density lipoprotein receptor-related protein gene is weakly associated with Alzheimer’s diseaseNeurosci Lett2592932PubMedCrossRefGoogle Scholar
  6. Beffert, U, Stolt, PC, Herz, J 2004Functions of lipoprotein receptors in neuronsJ Lipid Res45403409PubMedCrossRefGoogle Scholar
  7. Bertram, L, Tanzi, RE 2004Alzheimer’s disease: one disorder, too many genes?Hum Mol Genet13R135R141PubMedCrossRefGoogle Scholar
  8. Bi, S, Zhang, Y, Wu, J, Wang, D, Zhao, Q 2001Association between low-density lipoprotein receptor-related protein gene, butyrylcholinesterase gene and Alzheimer’s disease in ChineseChin Med Sci J167175PubMedGoogle Scholar
  9. Botstein, D, Risch, N 2003Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex diseaseNat Genet33228237PubMedCrossRefGoogle Scholar
  10. Bullido, MJ, Aldudo, J, Frank, A, Coria, F, Avila, J, Valdivieso, F 2000aA polymorphism in the tau gene associated with risk for Alzheimer’s diseaseNeurosci Lett2784952CrossRefGoogle Scholar
  11. Bullido, MJ, Guallar-Castillon, P, Artiga, MJ, Ramos, MC, Sastre, I, Aldudo, J, Frank, A, Coria, F, Rodriguez-Artalejo, F, Valdivieso, F 2000bAlzheimer’s risk associated with human apolipoprotein E, alpha-2 macroglobulin and lipoprotein receptor related protein polymorphisms: absence of genetic interactions, and modulation by genderNeurosci Lett289213216CrossRefGoogle Scholar
  12. Camelo, D, Arboleda, G, Yunis, JJ, Pardo, R, Arango, G, Solano, E, Lopez, L, Hedmont, D, Arboleda, H 2004Angiotensin-converting enzyme and alpha-2-macroglobulin gene polymorphisms are not associated with Alzheimer’s disease in Colombian patientsJ Neurol Sci2184751PubMedCrossRefGoogle Scholar
  13. Caspi, A, Sugden, K, Moffitt, TE, Taylor, A, Craig, IW, Harrington, H, McClay, J, Mill, J, Martin, J, Braithwaite, A, Poulton, R 2003Influence of life stress on depression: moderation by a polymorphism in the 5-HTT geneScience301386389PubMedCrossRefGoogle Scholar
  14. Causevic, M, Ramoz, N, Haroutunian, V, Davis, KL, Buxbaum, JD 2003Lack of association between the levels of the low-density lipoprotein receptor-related protein (LRP) and either Alzheimer dementia or LRP exon 3 genotypeJ Neuropathol Exp Neurol629991005PubMedGoogle Scholar
  15. Clark, LN, Levy, G, Tang, MX, Mejia-Santana, H, Ciappa, A, Tycko, B, Cote, LJ, Louis, ED, Mayeux, R, Marder, K 2003The Saitohin ‘Q7R’ polymorphism and tau haplotype in multi-ethnic Alzheimer disease and Parkinson’s disease cohortsNeurosci Lett3471720PubMedCrossRefGoogle Scholar
  16. Combarros, O, Rodero, L, Infante, J, Palacio, E, Llorca, J, Fernandez-Viadero, C, Pena, N, Berciano, J 2003Age-dependent association between the Q7R polymorphism in the Saitohin gene and sporadic Alzheimer’s diseaseDement Geriatr Cogn Disord16132135PubMedCrossRefGoogle Scholar
  17. Conrad, C, Vianna, C, Freeman, M, Davies, P 2002A polymorphic gene nested within an intron of the tau gene: implications for Alzheimer’s diseaseProc Natl Acad Sci USA9977517756PubMedCrossRefGoogle Scholar
  18. Conrad, C, Vianna, C, Schultz, C, Thal, DR, Ghebremedhin, E, Lenz, J, Braak, H, Davies, P 2004Molecular evolution and genetics of the Saitohin gene and tau haplotype in Alzheimer’s disease and argyrophilic grain diseaseJ Neurochem89179188PubMedCrossRefGoogle Scholar
  19. Cook, L, Brayne, CE, Easton, D, Evans, JG, Xuereb, J, Cairns, NJ, Rubinsztein, DC 2002No evidence for an association between Saitohin Q7R polymorphism and Alzheimer’s diseaseAnn Neurol52690691PubMedCrossRefGoogle Scholar
  20. Crawford, F, Freeman, M, Town, T, Fallin, D, Gold, M, Duara, R, Mullan, M 1999No genetic association between polymorphisms in the Tau gene and Alzheimer’s disease in clinic or population based samplesNeurosci Lett266193196PubMedCrossRefGoogle Scholar
  21. Demyttenaere, K Bruffaerts, R Posada-Villa, J Gasquet, I Kovess, V Lepine, JP Angermeyer, MC Bernert, S de Girolamo, G Morosini, P Polidori, G Kikkawa, T Kawakami, N Ono, Y Takeshima, T Uda, H Karam, EG Fayyad, JA Karam, AN Mneimneh, ZN Medina-Mora, ME Borges, G Lara, C de Graaf, R Ormel, J Gureje, O Shen, Y Huang, Y Zhang, M Alonso, J Haro, JM Vilagut, G Bromet, EJ Gluzman, S Webb, C Kessler, RC Merikangas, KR Anthony, JC Von Korff, MR Wang, PS Brugha, TS Aguilar-Gaxiola, S Lee, S Heeringa, S Pennell, BE Zaslavsky, AM Ustun, TB Chatterji, S WHO World Mental Health Survey Consortium2004Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health SurveysJAMA29125812590PubMedCrossRefGoogle Scholar
  22. Emahazion, T, Feuk, L, Jobs, M, Sawyer, SL, Fredman, D, St Clair, D, Prince, JA, Brookes, AJ 2001SNP association studies in Alzheimer’s disease highlight problems for complex disease analysisTrends Genet17407413PubMedCrossRefGoogle Scholar
  23. Green, EK, Thaker, U, McDonagh, AM, Iwatsubo, T, Lambert, JC, Chartier-Harlin, MC, Harris, JM, Pickering-Brown, SM, Lendon, CL, Mann, DM 2002A polymorphism within intron 11 of the tau gene is not increased in frequency in patients with sporadic Alzheimer’s disease, nor does it influence the extent of tau pathology in the brainNeurosci Lett324113116PubMedCrossRefGoogle Scholar
  24. Hatanaka, Y, Kamino, K, Fukuo, K, Mitsuda, N, Nishiwaki-Ueda, Y, Sato, N, Satoh, T, Yamamoto, H, Yoneda, H, Imagawa, M, Miki, T, Ohta, S, Ogihara, T 2000Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer’s disease in a Japanese populationClin Genet58319323PubMedCrossRefGoogle Scholar
  25. Hollenbach, E, Ackermann, S, Hyman, BT, Rebeck, GW 1998Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer’s diseaseNeurology5019051907PubMedGoogle Scholar
  26. Hu, CJ, Sung, SM, Liu, HC, Hsu, WC, Lee, LS, Lee, CC, Tsai, CH, Chang, JG 2000Genetic risk factors of sporadic Alzheimer’s disease among Chinese in TaiwanJ Neurol Sci181127131PubMedCrossRefGoogle Scholar
  27. Hu, M, Retz, W, Baader, M, Pesold, B, Adler, G, Henn, FA, Rosler, M, Thome, J 2000Promoter polymorphism of the 5-HT transporter and Alzheimer’s diseaseNeurosci Lett2946365PubMedCrossRefGoogle Scholar
  28. Kamboh, MI, Ferrell, RE, DeKosky, ST 1998Genetic association studies between Alzheimer’s disease and two polymorphisms in the low density lipoprotein receptor-related protein geneNeurosci Lett2446568PubMedCrossRefGoogle Scholar
  29. Kang, DE, Saitoh, T, Chen, X, Xia, Y, Masliah, E, Hansen, LA, Thomas, RG, Thal, LJ, Katzman, R 1997Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer’s diseaseNeurology495661PubMedGoogle Scholar
  30. Kolsch, H, Ptok, U, Mohamed, I, Schmitz, S, Rao, ML, Maier, W, Heun, R 2003Association of the C766T polymorphism of the low-density lipoprotein receptor-related protein gene with Alzheimer’s diseaseAm J Med Genet121B128130CrossRefGoogle Scholar
  31. Kwon, JM, Nowotny, P, Shah, PK, Chakraverty, S, Norton, J, Morris, JC, Goate, AM 2000Tau polymorphisms are not associated with Alzheimer’s diseaseNeurosci Lett2847780PubMedCrossRefGoogle Scholar
  32. Kunugi, H, Ueki, A, Otsuka, M, Isse, K, Hirasawa, H, Kato, N, Nabika, T, Kobayashi, S, Nanko, S 2000Alzheimer’s disease and 5-HTTLPR polymorphism of the serotonin transporter gene: no evidence for an associationAm J Med Genet96307309PubMedCrossRefGoogle Scholar
  33. Lahiri, DK, Nurnberger, JI,Jr 1991A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studiesNucl Acids Res195444PubMedGoogle Scholar
  34. Lambert, JC, Wavrant-De Vrieze, F, Amouyel, P, Chartier-Harlin, MC 1998Association at LRP gene locus with sporadic late-onset Alzheimer’s diseaseLancet35117871788PubMedCrossRefGoogle Scholar
  35. Lesch, KP 2004Gene-environment interaction and the genetics of depressionJ Psychiatry Neurosci29174184PubMedGoogle Scholar
  36. Li, T, Holmes, C, Sham, PC, Vallada, H, Birkett, J, Kirov, G, Lesch, KP, Powell, J, Lovestone, S, Collier, D 1997Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer’s diseaseNeuroreport8683686PubMedGoogle Scholar
  37. Lilius, L, Froelich Fabre, S, Basun, H, Forsell, C, Axelman, K, Mattila, K, Andreadis, A, Viitanen, M, Winblad, B, Fratiglioni, L, Lannfelt, L 1999Tau gene polymorphisms and apolipoprotein E epsilon4 may interact to increase risk for Alzheimer’s diseaseNeurosci Lett2772932PubMedCrossRefGoogle Scholar
  38. Lohmueller, KE, Pearce, CL, Pike, M, Lander, ES, Hirschhorn, JN 2003Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common diseaseNat Genet33177182PubMedCrossRefGoogle Scholar
  39. Luedecking-Zimmer, E, DeKosky, ST, Nebes, R, Kamboh, MI 2003Association of the 3′ UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimer’s diseaseAm J Med Genet B Neuropsychiatr Genet117114117PubMedCrossRefGoogle Scholar
  40. McIlroy, SP, Dynan, KB, Vahidassr, DJ, Lawson, JT, Patterson, CC, Passmore, P 2001Common polymorphisms in LRP and A2M do not affect genetic risk for Alzheimer disease in Northern IrelandAm J Med Genet105502506PubMedCrossRefGoogle Scholar
  41. Mossner, R, Schmitt, A, Syagailo, Y, Gerlach, M, Riederer, P, Lesch, KP 2000The serotonin transporter in Alzheimer’s and Parkinson’s diseaseJ Neural Transm [Suppl]60345350Google Scholar
  42. North, BV, Curtis, D, Cassell, PG, Hitman, GA, Sham, PC 2003Assessing optimal neural network architecture for identifying disease-associated multi-marker genotypes using a permutation test, and application to calpain 10 polymorphisms associated with diabetesAnn Hum Genet67348356PubMedCrossRefGoogle Scholar
  43. Oliva, R, Tolosa, E, Ezquerra, M, Molinuevo, JL, Valldeoriola, F, Burguera, J, Calopa, M, Villa, M, Ballesta, F 1998Significant changes in the tau A0 and A3 alleles in progressive supranuclear palsy and improved genotyping by silver detectionArch Neurol5511221124PubMedCrossRefGoogle Scholar
  44. Oliveira, JR, Gallindo, RM, Maia, LG, Brito-Marques, PR, Otto, PA, Passos-Bueno, MR, Morais, MA,Jr, Zatz, M 1998The short variant of the polymorphism within the promoter region of the serotonin transporter gene is a risk factor for late onset Alzheimer’s diseaseMol Psychiatry3438441PubMedCrossRefGoogle Scholar
  45. Oliveira, JR, Shimokomaki, CM, Brito-Marques, PR, Gallindo, RM, Okuma, M, Maia, LG, Otto, PA, Passos-Bueno, MR, Zatz, M 1999The association of the short variant of the 5-HTTPLR polymorphism and the apoE epsilon4 allele does not increase the risk for late onset Alzheimer’s diseaseMol Psychiatry41920PubMedCrossRefGoogle Scholar
  46. Oliveira, SA, Martin, ER, Scott, WK, Nicodemus, KK, Small, GW, Schmechel, DE, Doraiswamy, PM, Roses, AD, Saunders, AM, Gilbert, JR, Haines, JL, Vance, JM, Pericak-Vance, MA 2003The Q7R Saitohin gene polymorphism is not associated with Alzheimer diseaseNeurosci Lett347143146PubMedCrossRefGoogle Scholar
  47. Panza, F, D’Introno, A, Colacicco, AM, Capurso, C, Basile, AM, Capurso, S, Capurso, A, Solfrizzi, V 2004Regional European differences in allele and genotype frequencies of low density lipoprotein receptor-related protein 1 polymorphism in Alzheimer’s diseaseAm J Med Genet126B6973CrossRefGoogle Scholar
  48. Parra-Bonilla, G, Arboleda, G, Yunis, J, Solano, E, Pardo, R, Arango, G, Hedmont, D, Arboleda, H 2003Haplogroup analysis of the risk associated with APOE promoter polymorphisms (−219T/G, −491A/T and −427T/C) in Colombian Alzheimer’s disease patientsNeurosci Lett349159162PubMedCrossRefGoogle Scholar
  49. Peplonska, B, Zekanowski, C, Religa, D, Czyzewski, K, Styczynska, M, Pfeffer, A, Gabryelewicz, T, Golebiowski, M, Luczywek, E, Wasiak, B, Barczak, A, Chodakowska, M, Barcikowska, M, Kuznicki, J 2003Strong association between Saitohin gene polymorphism and tau haplotype in the Polish populationNeurosci Lett348163166PubMedCrossRefGoogle Scholar
  50. Perry, RT, Collins, JS, Harrell, LE, Acton, RT, Go, RC 2001Investigation of association of 13 polymorphisms in eight genes in southeastern African American Alzheimer disease patients as compared to age-matched controlsAm J Med Genet105332342PubMedCrossRefGoogle Scholar
  51. Pradilla, AG Vesga, ABE Leon-Sarmiento, FE GENECO2003National neuroepidemiological study in Colombia (EPINEURO)Rev Panam Salud Publica14104111Google Scholar
  52. Prince, JA, Feuk, L, Sawyer, SL, Gottfries, J, Ricksten, A, Nagga, K, Bogdanovic, N, Blennow, K, Brookes, AJ 2001Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer’s diseaseEur J Hum Genet9437444PubMedCrossRefGoogle Scholar
  53. Pritchard, A, Harris, J, Pritchard, CW, St Clair, D, Lemmon, H, Lambert, JC, Chartier-Harlin, MC, Hayes, A, Thaker, U, Iwatsubo, T, Mann, DM, Lendon, C 2005Association study and meta-analysis of low-density lipoprotein receptor related protein in Alzheimer’s diseaseNeurosci Lett382221226PubMedCrossRefGoogle Scholar
  54. Purcell, S, Cherny, SS, Sham, PC 2003Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traitsBioinformatics19149150PubMedCrossRefGoogle Scholar
  55. Rocchi, A, Micheli, D, Ceravolo, R, Manca, ML, Tognoni, G, Siciliano, G, Murri, L 2003Serotoninergic polymorphisms (5-HTTLPR and 5-HT2A): association studies with psychosis in Alzheimer diseaseGenet Test7309314PubMedCrossRefGoogle Scholar
  56. Roks, G, Dermaut, B, Heutink, P, Julliams, A, Backhovens, H, Van de Broeck, M, Serneels, S, Hofman, A, Van Broeckhoven, C, van Duijn, CM, Cruts, M 1999Mutation screening of the tau gene in patients with early-onset Alzheimer’s diseaseNeurosci Lett277137139PubMedCrossRefGoogle Scholar
  57. Russ, C, Powell, JF, Zhao, J, Baker, M, Hutton, M, Crawford, F, Mullan, M, Roks, G, Cruts, M, Lovestone, S 2001The microtubule associated protein Tau gene and Alzheimer’s disease – an association study and meta-analysisNeurosci Lett3149296PubMedCrossRefGoogle Scholar
  58. Sanchez-Guerra, M, Combarros, O, Infante, J, Llorca, J, Berciano, J, Fontalba, A, Fernandez-Luna, JL, Pena, N, Fernandez-Viadero, C 2001Case-control study and meta-analysis of low density lipoprotein receptor-related protein gene exon 3 polymorphism in Alzheimer’s diseaseNeurosci Lett3161720PubMedCrossRefGoogle Scholar
  59. Schraen-Maschke, S, Dhaenens, CM, Delacourte, A, Sablonniere, B 2004Microtubule-associated protein tau gene: a risk factor in human neurodegenerative diseasesNeurobiol Dis15449460PubMedCrossRefGoogle Scholar
  60. Selkoe, DJ 2002Alzheimer’s disease is a synaptic failureScience298789791PubMedCrossRefGoogle Scholar
  61. Seripa, D, Matera, MG, D’Andrea, RP, Gravina, C, Masullo, C, Daniele, A, Bizzarro, A, Rinaldi, M, Antuono, P, Wekstein, DR, Dal Forno, G, Fazio, VM 2004Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphismNeurology6216311633PubMedGoogle Scholar
  62. Serretti, A, Smeraldi, E 2004Neural network analysis in pharmacogenetics of mood disordersBMC Med Genet927CrossRefGoogle Scholar
  63. Streffer, JR, Papassotiropoulos, A, Kurosinski, P, Signorell, A, Wollmer, MA, Tsolaki, M, Iakovidou, V, Horndli, F, Bosset, J, Gotz, J, Nitsch, RM, Hock, C 2003Saitohin gene is not associated with Alzheimer’s diseaseJ Neurol Neurosurg Psychiatry74362363PubMedCrossRefGoogle Scholar
  64. Sweet, RA, Pollock, BG, Sukonick, DL, Mulsant, BH, Rosen, J, Klunk, WE, Kastango, KB, DeKosky, ST, Ferrell, RE 2001The 5-HTTPR polymorphism confers liability to a combined phenotype of psychotic and aggressive behavior in Alzheimer diseaseInt Psychogeriatr13401409PubMedCrossRefGoogle Scholar
  65. Tanahashi, H, Asada, T, Tabira, T 2004Association between tau polymorphism and male early-onset Alzheimer’s diseaseNeuroreport15175179PubMedCrossRefGoogle Scholar
  66. The International HapMap Consortium2003The International HapMap ProjectNature426789796CrossRefGoogle Scholar
  67. Tsai, SJ, Hong, CJ, Liu, TY, Cheng, CY, Liu, HC 2001Association study for a functional serotonin transporter gene polymorphism and late-onset Alzheimer’s disease for Chinese patientsNeuropsychobiology442730PubMedCrossRefGoogle Scholar
  68. Tishkoff, SA, Kidd, KK 2004Implications of biogeography of human populations for ‘race’ and medicineNat Genet36S21S27PubMedCrossRefGoogle Scholar
  69. Uhl, GR, Grow, RW 2004The burden of complex genetics in brain disordersArch Gen Psychiatry61223229PubMedCrossRefGoogle Scholar
  70. Verpillat, P, Bouley, S, Campion, D, Hannequin, D, Dubois, B, Belliard, S, Puel, M, Thomas-Anterion, C, Agid, Y, Brice, A, Clerget-Darpoux, F 2001Use of haplotype information to test involvement of the LRP gene in Alzheimer’s disease in the French populationEur J Hum Genet9464468PubMedCrossRefGoogle Scholar
  71. Verpillat, P Ricard, S Hannequin, D Dubois, B Bou, J Camuzat, A Pradier, L Frebourg, T Brice, A Clerget-Darpoux, F Deleuze, JF Campion, D French Study Group on Alzheimer’s Disease and Frontotemporal Dementia2002Is the saitohin gene involved in neurodegenerative diseases?Ann Neurol52829832PubMedCrossRefGoogle Scholar
  72. Warwick Daw, E, Payami, H, Nemens, EJ, Nochlin, D, Bird, TD, Schellenberg, GD, Wijsman, EM 2000The number of trait loci in late-onset Alzheimer diseaseAm J Hum Genet66196204CrossRefGoogle Scholar
  73. Wimo, A, Winblad, B, Aguero-Torres, H, von Strauss, E 2003The magnitude of dementia occurrence in the worldAlzheimer Dis Assoc Disord176367PubMedCrossRefGoogle Scholar
  74. Woodward, R, Singleton, AB, Gibson, AM, Edwardson, JA, Morris, CM 1998LRP gene and late-onset Alzheimer’s diseaseLancet352239240PubMedCrossRefGoogle Scholar
  75. Yunis, JJ, Garcia, O, Baena, A, Arboleda, G, Uriarte, I, Yunis, E 2000aPopulation frequency for the short tandem repeat loci D18S849, D3S1744, and D12S1090 in Caucasian-Mestizo and African descent populations of ColombiaJ Forensic Sci45429431Google Scholar
  76. Yunis, JJ, Garcia, O, Uriarte, I, Yunis, EJ 2000bPopulation data on 6 short tandem repeat loci in a sample of Caucasian-Mestizos from ColombiaInt J Legal Med113175178CrossRefGoogle Scholar
  77. Zill, P, Padberg, F, de Jonge, S, Hampel, H, Burger, K, Stubner, S, Boetsch, T, Jurgen Moller, H, Ackenheil, M, Bondy, B 2000Serotonin transporter (5-HTT) gene polymorphism in psychogeriatric patientsNeurosci Lett284113115PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • D. A. Forero
    • 1
  • G. Arboleda
    • 1
    • 5
  • J. J. Yunis
    • 1
    • 2
  • R. Pardo
    • 1
    • 3
  • H. Arboleda
    • 1
    • 4
  1. 1.Grupo de Neurociencias, Facultad de Medicina e Instituto de GenéticaUniversidad Nacional de ColombiaBogotáColombia
  2. 2.Departamento de PatologíaUniversidad Nacional de ColombiaBogotáColombia
  3. 3.Departamento de MedicinaUniversidad Nacional de ColombiaBogotáColombia
  4. 4.Departamento de Pediatría, Facultad de MedicinaUniversidad Nacional de ColombiaBogotáColombia
  5. 5.Departamento de Ciencias Básicas, Facultad de MedicinaUniversidad del RosarioBogotáColombia

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