Journal of Neural Transmission

, Volume 112, Issue 12, pp 1687–1694 | Cite as

The North American Multiple System Atrophy Study Group

  • S. Gilman
  • S. J. May
  • C. W. Shults
  • C. M. Tanner
  • W. Kukull
  • V. M.-Y. Lee
  • E. Masliah
  • P. Low
  • P. Sandroni
  • J. Q. Trojanowski
  • L. Ozelius
  • T. Foroud
  • and The North American Multiple System Atrophy Study Group
Article

Summary.

The North American Multiple System Atrophy Study Group involves investigators in 12 US medical centers funded by a grant from the National Institutes of Health. The objectives are to examine the environmental and genetic risk factors for MSA; elucidate pathogenic mechanisms underlying the disorder; and refine evaluations used for assessment. During its first year, the group enrolled 87 patients, implemented four cores, and initiated four scientific projects. Most patients among the 87 had parkinsonian features, which frequently began asymmetrically and remained asymmetrical; one-third responded to levodopa and many developed levodopa complications; almost two-thirds of the patients had cerebellar dysfunction, of these 90% had ataxia; urinary incontinence occurred commonly, and sleep disorders affected most. The investigators studied the effects of oxidative and nitrative stress upon the formation of alpha-synuclein inclusions; generated transgenic models of alpha-synuclein accumulation that recapitulate several behavioral and neuropathological features of MSA; and compared the severity of the autonomic features of MSA, Parkinson’s disease and dementia with Lewy bodies.

Keywords: Multiple system atrophy, parkinsonism, cerebellar ataxia, autonomic failure. 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Benrud-Larson, LM, Sandroni, P, Schrag, A, Low, PA 2005Depressive symptoms and life satisfaction in patients with multiple system atrophy.Mov Disord157175Google Scholar
  2. Giasson, BI, Forman, MS, Higuchi, M, Golbe, LI, Graves, CL, Kotzbauer, PT, Trojanowski, JQ, Lee, VM 2003aInitiation and synergistic fibrillization of tau and alpha-synuclein.Science300636640CrossRefGoogle Scholar
  3. Giasson, BI, Mabon, ME, Duda, JE, Montine, TJ, Robertson, D, Hurtig, HI, Lee, VM, Trojanowski, JQ 2003bTau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy.Acta Neuropathol (Berl)106243250Google Scholar
  4. Lee, VM, Giasson, BI, Trojanowski, JQ 2004More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases.Trends Neurosci27129134CrossRefPubMedGoogle Scholar
  5. Murray, IJ, Medford, MA, Guan, HP, Rueter, SM, Trojanowski, JQ, Lee, VM 2003Synphilin in normal human brains and in synucleinopathies: studies with new antibodies.Acta Neuropathol (Berl)105177184Google Scholar
  6. Norris, EH, Giasson, BI, Ischiropoulos, H, Lee, VM 2003Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications.J Biol Chem2782723027240CrossRefPubMedGoogle Scholar
  7. Pawlyk, AC, Giasson, BI, Sampathu, DM, Perez, FA, Lim, KL, Dawson, VL, Dawson, TM, Palmiter, RD, Trojanowski, JQ, Lee, VM 2003Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.J Biol Chem2784812048128CrossRefPubMedGoogle Scholar
  8. Sampathu, DM, Giasson, BI, Pawlyk, AC, Trojanowski, JQ, Lee, VM 2003Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies.Am J Pathol16391100PubMedGoogle Scholar
  9. Thaisetthawatkul, P, Boeve, BF, Benarroch, EE, Sandroni, P, Ferman, TJ, Petersen, R, Low, PA 2004Autonomic dysfunction in dementia with Lewy bodies.Neurology6218041809PubMedGoogle Scholar

Copyright information

© Springer-Verlag/Wien 2005

Authors and Affiliations

  • S. Gilman
    • 1
  • S. J. May
    • 2
    • 7
  • C. W. Shults
    • 3
    • 7
  • C. M. Tanner
    • 4
  • W. Kukull
    • 5
  • V. M.-Y. Lee
    • 6
  • E. Masliah
    • 7
  • P. Low
    • 8
  • P. Sandroni
    • 8
  • J. Q. Trojanowski
    • 6
  • L. Ozelius
    • 9
  • T. Foroud
    • 10
  • and The North American Multiple System Atrophy Study Group
  1. 1.Department of NeurologyUniversity of MichiganAnn ArborUSA
  2. 2.Department of Family & Preventive MedicineUniversity of California San DiegoLa JollaUSA
  3. 3.VA San Diego Healthcare SystemSan DiegoUSA
  4. 4.Department of Clinical ResearchParkinson’s InstituteSunnyvaleUSA
  5. 5.Department of EpidemiologyUniversity of WashingtonSeattleUSA
  6. 6.Department of Pathology & Laboratory Medicine, Center on Neurological Disease ResearchUniversity of PennsylvaniaPhiladelphiaUSA
  7. 7.Department of NeurosciencesUniversity of CaliforniaSan Diego, La JollaUSA
  8. 8.Department of NeurologyMayo ClinicRochesterUSA
  9. 9.Department of Molecular GeneticsAlbert Einstein College of MedicineBronxUSA
  10. 10.Department of Medicine and Molecular GeneticsIndiana University School of MedicineIndianapolisUSA

Personalised recommendations