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Journal of Neural Transmission

, Volume 112, Issue 11, pp 1547–1564 | Cite as

Traumatic brain injury: cause or risk of Alzheimer’s disease? A review of experimental studies

  • J. Szczygielski
  • A. Mautes
  • W. I. Steudel
  • P. Falkai
  • T.A. Bayer
  • O. Wirths
Review

Summary.

Traumatic Brain Injury is the leading cause of death and disability among young individuals in our society. Moreover, according to some epidemiological studies, head trauma is one of the most potent environmental risk factors for subsequent development of Alzheimer’s disease. Interestingly, pathological features that are present also in Alzheimer’s disease (in particular deposition of beta-amyloid protein) were observed in traumatised brains already a few hours after the initial insult. The primary objective of this review is to present methodology and results of numerous recent human and animal studies dealing with this issue. Special emphasis was placed on head trauma experiments in transgenic mouse models of Alzheimer’s disease. We further evaluate the connection between traumatic brain insults and subsequent development of dementia and try to differentiate between primary and secondary pathological mechanisms.

Keywords: Brain trauma, axonal injury, Alzheimer’s disease, transgenic mice, amyloid precursor protein. 

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Copyright information

© Springer-Verlag/Wien 2005

Authors and Affiliations

  • J. Szczygielski
    • 2
    • 3
  • A. Mautes
    • 3
  • W. I. Steudel
    • 3
  • P. Falkai
    • 1
  • T.A. Bayer
    • 1
    • 2
  • O. Wirths
    • 1
    • 2
  1. 1.Department of PsychiatrySaarland UniversityHomburgGermany
  2. 2.Section NeurobiologySaarland UniversityHomburgGermany
  3. 3.Department of NeurosurgerySaarland UniversityHomburgGermany

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