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Journal of Neural Transmission

, Volume 112, Issue 10, pp 1411–1416 | Cite as

A prospective study of serum ghrelin levels in patients treated with clozapine

  • F. M. Theisen
  • S. Gebhardt
  • T. Brömel
  • B. Otto
  • W. Heldwein
  • M. Heinzel-Gutenbrunner
  • J.-C. Krieg
  • H. Remschmidt
  • M. Tschöp
  • J. Hebebrand
Article

Summary.

We investigated serum ghrelin levels (SGL) in 12 patients with schizophrenia over a 10-week period after initiation of clozapine treatment. In contrast to increments of body mass indices (BMI, kg/m2) and serum leptin levels (SLL), no significant change in SGL was detected. Inverse correlations between delta SGL and delta SLL did not reach statistical significance. Linear mixed model analysis could not detect effects of age, sex, BMI, SLL and serum clozapine levels on SGL. Our results do not support a causal involvement of ghrelin in clozapine-related weight gain.

Keywords: Leptin, weight gain, body mass index, antipsychotics, neuroleptics. 

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Copyright information

© Springer-Verlag/Wien 2005

Authors and Affiliations

  • F. M. Theisen
    • 1
  • S. Gebhardt
    • 1
  • T. Brömel
    • 1
    • 2
  • B. Otto
    • 3
  • W. Heldwein
    • 3
  • M. Heinzel-Gutenbrunner
    • 1
    • 4
  • J.-C. Krieg
    • 5
  • H. Remschmidt
    • 1
  • M. Tschöp
    • 6
  • J. Hebebrand
    • 1
    • 7
  1. 1.Clinical Research Group, Department of Child and Adolescent PsychiatryPhilipps UniversityMarburgGermany
  2. 2.Day Hospital and Outpatients’ Department of Child and Adolescent PsychiatryDistrict General Hospital GummersbachGermany
  3. 3.Medical Department – InnenstadtUniversity HospitalMunichGermany
  4. 4.Institute of Medical Biometry and Epidemiology, Philipps UniversityMarburgGermany
  5. 5.Department of PsychiatryPhilipps UniversityMarburgGermany
  6. 6.Department of Psychiatry, Obesity Research CentreUniversity of Cincinnati Medical CentreCincinnatiUSA
  7. 7.Department of Child and Adolescent PsychiatryUniversity of Duisburg-EssenEssenGermany

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