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Journal of Neural Transmission

, Volume 110, Issue 11, pp 1279–1288 | Cite as

Expression of cannabinoid CB1 receptor mRNA in basal ganglia of normal and parkinsonian human brain

  • M. J. Hurley
  • D. C. Mash
  • P. Jenner

Summary.

Reverse transcription polymerase chain reaction (RT-PCR) was used to examine the expression of the cannabinoid CB1 receptor mRNA in post-mortem brain tissue obtained from normal subjects and patients dying with Parkinson’s disease. CB1 receptor mRNA was detected in striatal (nucleus accumbens, caudate nucleus and putamen) and extrastriatal (globus pallidus, substantia nigra) brain regions. In parkinsonian tissue the level of CB1 receptor mRNA was decreased in the caudate nucleus, anterior dorsal putamen and external segment of the globus pallidus, but remained unchanged in the other brain areas examined. These results show that CB1 receptor mRNA expression was altered in Parkinson’s disease (though the effects of drug treatment can not be ruled out) and indicate that cannabinoid CB1 receptor mRNA expression was affected by alterations in dopaminergic systems.

Keywords: Parkinson’s disease, cannabinoid CB1 receptor mRNA, basal ganglia, RT-PCR. 

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Copyright information

© Springer-Verlag/Wien 2003

Authors and Affiliations

  • M. J. Hurley
    • 1
  • D. C. Mash
    • 1
  • P. Jenner
    • 2
  1. 1.Neurology Department, University of Miami School of Medicine, Miami, FL, U.S.A.US
  2. 2.Neurodegenerative Disease Research Centre, Guy’s, King’s and St. Thomas’ School of Biomedical Sciences, King’s College, London, United KingdomGB

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