Journal of Neural Transmission

, Volume 110, Issue 10, pp 1149–1160 | Cite as

CSF-tau, CSF-Aß1-42, ApoE-genotype and clinical parameters in the diagnosis of Alzheimer’s disease: combination of CSF-tau and MMSE yields highest sensitivity and specificity

  • S. Ganzer
  • S. Arlt
  • V. Schoder
  • C. Buhmann
  • E.-M. Mandelkow
  • U. Finckh
  • U. Beisiegel
  • D. Naber
  • T. Müller-Thomsen

Summary.

This study evaluated the sensitivity and specificity of the cerebrospinal fluid (CSF) levels of tau-protein, amyloid-ß-peptide 1-42 (Aß1-42), ApoE-genotype and the degree of cognitive decline as diagnostic markers for Alzheimer’s disease (AD). Data was obtained from 105 AD patients and 68 controls.

Median CSF-tau levels were increased (512 pg/ml vs. 145 pg/ml, p<0.001) and Aß1-42-levels were decreased (238.5 pg/ml vs. 310 pg/ml, p<0.001) in AD patients compared to controls. A weak correlation was found between CSF-Aß1-42 and MMSE score (r=.245). Within all subjects, a correlation of CSF-Aß1-42 (r=−.337) and CSF-tau (r=.384) with age was found. The combination of CSF-tau levels and MMSE revealed the highest sensitivity (92%) and specificity (87%).

In summary, CSF-tau was a useful biological marker to discriminate AD from normal aging, neurological and psychiatric disorders. CSF-Aß1-42 showed no additional benefit in discriminating patients from controls but might be useful for tracking the severity of the disease.

Keywords: Alzheimer disease, tau-protein, amyloid-beta 1-42 

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Copyright information

© Springer-Verlag/Wien 2003

Authors and Affiliations

  • S. Ganzer
    • 1
  • S. Arlt
    • 1
    • 2
  • V. Schoder
    • 3
  • C. Buhmann
    • 4
  • E.-M. Mandelkow
    • 5
  • U. Finckh
    • 6
  • U. Beisiegel
    • 2
  • D. Naber
    • 1
  • T. Müller-Thomsen
    • 1
  1. 1.Department of Psychiatry and Psychotherapy, Hamburg, GermanyDE
  2. 2.Institute for Medical Biochemistry and Molecular Biology, Department of Molecular Cell Biology, Hamburg, GermanyDE
  3. 3.Institute for Mathematics and Data Science in Medicine, Hamburg, GermanyDE
  4. 4.Department of Neurology, Hamburg, GermanyDE
  5. 5.Max-Planck-Unit for Structural Molecular Biology, Hamburg, GermanyDE
  6. 6.Institute for Human Genetics, University Hospital Hamburg-Eppendorf, Hamburg, GermanyDE

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