Journal of Neural Transmission

, Volume 110, Issue 6, pp 671–680 | Cite as

Reduced phosphorylation of cyclic AMP-responsive element binding protein in the postmortem orbitofrontal cortex of patients with major depressive disorder

  • S. Yamada
  • M. Yamamoto
  • H. Ozawa
  • P. Riederer
  • T. Saito

Summary.

In this study, we examined the amounts of cAMP-responsive element binding protein (CREB) and its phosphorylated form in homogenate preparations from postmortem orbitofrontal cortices of antidepressant drug-free patients with major depressive disorder and age-matched controls by immunoblotting. Immunoreactivies of both CREB and phosphorylated CREB were significantly decreased in depressive subjects compared to controls. The immunoreactivity of phosphorylated CREB was diminished to a greater extent than that of CREB in depressive patients. It has been indicated from animal studies that a transcription factor likely mediates neural plasticity in the mammalian brain and neural tissues. Our results suggest that alterations in the cAMP signaling system, especially in CREB, may be involved in the pathophysiology of depression and be potential targets for antidepressant treatment.

Keywords: Major depressive disorder transcription factor postmortem human brain cAMP-responsive element binding protein (CREB) phosphorylation antidepressant. 

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Copyright information

© Springer-Verlag Wien 2003

Authors and Affiliations

  • S. Yamada
    • 1
  • M. Yamamoto
    • 1
  • H. Ozawa
    • 1
  • P. Riederer
    • 2
  • T. Saito
    • 1
  1. 1. Department of Neuropsychiatry, School of Medicine, Sapporo Medical University, Sapporo, JapanJP
  2. 2. Clinical Neurochemistry, Department of Psychiatry, University of Würzburg, Würzburg, GermanyDE

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