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Acta Neurochirurgica

, Volume 141, Issue 1, pp 13–19 | Cite as

Intra-Arterial Infusion of Fasudil Hydrochloride for Treating Vasospasm Following Subarachnoid Haemorrhage

  • E. Tachibana
  • T. Harada
  • M. Shibuya
  • K. Saito
  • M. Takayasu
  • Y. Suzuki
  • J. Yoshida

Summary

 In this pilot study we treated cerebral vasospasm in patients with subarachnoid haemorrhage to assess intra-arterial fasudil hydrochloride. We analysed effects of intra-arterial infusion on angiographically evident cerebral vasospasm in 10 patients including 3 with symptoms of vasospasm. Over 10 to 30 min 15 to 60 mg was administered via the proximal internal carotid artery or vertebral artery following standard angiography, without superselective techniques. A total of 24 arterial territories (21 internal carotid, 3 vertebral) were treated. Angiographic improvement of vasospasm was demonstrated in 16 arterial territories (local dilation in 2, diffuse dilation in 14) in 9 patients. In 2 symptomatic patients, intra-arterial fasudil hydrochloride was associated with resolution of symptoms without sequelae. In the third symptomatic patient the benefit of fasudil hydrochloride was only temporary, and a large cerebral infarction occurred. All asymptomatic patients showed no progression of angiographic to symptomatic vasospasm after treatment with intra-arterial fasudil hydrochloride. No adverse effect was encountered.

 Keywords:Cerebral vasospasm; fasudil hydrochloride; intra-arterial infusion; subarachnoid haemorrhage. 

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Copyright information

© Springer-Verlag Wien 1999

Authors and Affiliations

  • E. Tachibana
    • 1
  • T. Harada
    • 2
  • M. Shibuya
    • 3
  • K. Saito
    • 1
  • M. Takayasu
    • 1
  • Y. Suzuki
    • 1
  • J. Yoshida
    • 1
  1. 1.Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan JP
  2. 2.Department of Neurosurgery, Kasugai City Hospital, Kasugai, Japan JP
  3. 3.Department of Neurosurgery, Chukyo Hospital, Nagoya, JapanJP

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