Letter to the editor regarding “A retrospective study of the effect of fibrinogen levels during fresh frozen plasma transfusion in patients with traumatic brain injury”

  • Chenghong Wang
  • Xiaodong Niu
  • Zhigang Lan
  • Yuekang ZhangEmail author
Letter to the editor - Brain trauma
Part of the following topical collections:
  1. Brain trauma

Dear Editor,

We read with great interest the recent article by Nakae et al. entitled “A retrospective study of the effect of fibrinogen levels during fresh frozen plasma transfusion in patients with traumatic brain injury” [8]. The authors conclude that the outcomes of TBI (traumatic brain injury) patients are significantly better in the high-fibrinogen subgroup (concentration 3 h after injury ≥ 150 mg/dL) than in the low-fibrinogen subgroup (< 150 mg/dL). Moreover, they recommend FFP transfusion to maintain fibrinogen concentrations at ≥ 150 mg/dL to improve the outcomes in TBI patients.

A first aspect is whether the difference in outcomes of patients between subgroups was caused by the plasma fibrinogen concentration. Hypofibrinogenemia after TBI partly results from consumption for generating hematoma and blood loss requiring fluid resuscitation [4]. Larger baseline intracranial hematoma and higher blood loss indicate more severe injury, which may lead to the worse outcomes [9]....


Compliance with ethical standards

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of NeurosurgeryWest China Hospital of Sichuan UniversityChengduPeople’s Republic of China

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