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Mathematical skills in children with pilocytic astrocytoma

  • Silvia Benavides-Varela
  • Riccardina Lorusso
  • Valentina Baro
  • Luca Denaro
  • Nancy Estévez-Pérez
  • Daniela Lucangeli
  • Domenico D’Avella
  • Carlo Semenza
Original Article - Pediatric Neurosurgery
  • 9 Downloads
Part of the following topical collections:
  1. Pediatric Neurosurgery

Abstract

Background

Pediatric patients with circumscribed cerebellar pilocytic astrocytoma (PA) tumors generally perform within the normal range on neuropsychological tests after a complete tumor resection. The outcome in academically relevant abilities such as mathematics, which in adults involve some cerebellar functions, is however much less understood. The aim of this study is to retrospectively investigate the neuroplasticity of mathematical skills and associated cognitive functions following cerebellar resection of PA in pediatric patients.

Methods

Twenty-two children (mean age = 11.2 + 1.8), including 11 PA patients (females = 6) and 11 healthy controls (females = 6), were administered a battery of mathematical (MaT) and neuropsychological tests. Single-case statistical analyses were carried out (Crawford’s t) as well as between-group comparisons (Wilcoxon test). Spearman correlations between MaT and neuropsychological tests were calculated.

Results

Thirty-six percent of the patients showed difficulties in some mathematical tasks, 50% of them within a broader cognitive deficit. Verbal working memory was associated with MaT performance both in patients and controls while, crucially, visuospatial memory, and visual-motor integration were associated with MaT in patients only. Among patients, MaT correlated negatively with tumor size and positively with the interval surgery test.

Conclusions

The results evince an overall recovery of mathematical abilities despite PA in the majority of patients. This functional reestablishment is supported by visuospatial and visuomotor integration functions that contribute to set up emerging mathematical skills in these patients. Higher levels of compensation are found in more developed tumors as compared to smaller ones.

Keywords

Low-grade pilocytic astrocytoma Surgical resection Cerebellum Neuropsychological sequelae Mathematical performance 

Notes

Acknowledgments

We wish to thank Laura Milanese for her valuable assistance on the recruitment of patients. Our gratitude also goes to the parents of all the children for their participation.

Funding

This study was funded by the University of Padua (Grant Number: STPD11B88HM). The sponsor had no role in the design or conduct of this research.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

701_2018_3744_MOESM1_ESM.pdf (33 kb)
ESM 1 (PDF 32 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Silvia Benavides-Varela
    • 1
    • 2
    • 3
  • Riccardina Lorusso
    • 4
    • 5
  • Valentina Baro
    • 4
  • Luca Denaro
    • 4
  • Nancy Estévez-Pérez
    • 6
  • Daniela Lucangeli
    • 1
  • Domenico D’Avella
    • 4
  • Carlo Semenza
    • 3
    • 4
  1. 1.Department of Developmental Psychology and SocializationUniversity of PadovaPadovaItaly
  2. 2.Department of General PsychologyUniversity of PadovaPadovaItaly
  3. 3.IRCCS San Camillo Hospital FoundationNeuropsychology UnitVeniceItaly
  4. 4.Department of Neuroscience (Padova Neuroscience Center)University of PadovaPadovaItaly
  5. 5.Department of MedicineUniversity of PadovaPadovaItaly
  6. 6.Brain Development LaboratoryCuban Neurosciences CentreHavanaCuba

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