Eight-year survival of a recurrent glioblastoma patient treated with molecularly tailored therapy: a case report
Treatment options for recurrent glioblastoma are scarce; targeted therapy trials were disappointing, probably due to enrollment of patients without molecular selection. We treated with bevacizumab and erlotinib a 66-year-old male suffering from recurrent glioblastoma, IDH-wildtype and MGMT unmethylated, after three neurosurgeries. Treatment was tailored on molecular profile of recurrent tumor—namely, EGFRvIII positivity, VEGF overexpression, normal PTEN, low total VEGF and VEGF-121 mRNA—and resulted in complete, exceptionally durable response (51-month progression-free survival). Notably, histology of further recurrence after therapy was reminiscent of sarcoma. We suggest a thorough molecular screening for personalization of targeted therapy in recurrent glioblastoma.
KeywordsGlioblastoma Targeted therapy Tailored therapy Bevacizumab Erlotinib
Epidermal growth factor receptor
Vascular endothelial growth factor
The authors thank the Head Nurse, Giovanna Farisei, and all the nurses of the Department of Neurosurgery of Fondazione Policlinico Universitario A. Gemelli IRCCS for their invaluable work in giving care to GBM patients.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
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