Abstract
Although liposarcomas are the most common soft tissue sarcomas, their intracranial variants are extremely rare. Here, we present a case of a primary intracranial myxoid liposarcoma in a 23-year-old Japanese man who presented with generalized seizures and a mass in the left frontal lobe. The tumor was totally removed, and histological analyses pointed to liposarcoma. Thirteen years after his initial treatment, the patient presented with right-side weakness and local recurrence of tumor was discovered. Histology from the second resection confirmed the diagnosis of myxoid liposarcoma. Shortly after the second resection, progressive, new intracranial lesions were observed and despite a third resection, extensive intracerebral invasion by the tumor proved fatal. The histological features of myxoid liposarcoma were essentially similar with each recurrence, but the aggressive tumor behavior after the second operation did not align with expectations based on histological classification.
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Acknowledgements
We are grateful to Dr. K. Oka for the primary pathological diagnosis, Dr. I. Emura (Niigata University Hospital) for the helpful suggestions for the diagnosis, and Dr. M. Ito (Shimura Hospital) for supplying clinical data after the third operation. We also thank Dr. Bryan J. Mathis of the University of Tsukuba Medical English Communication Center for the native English language revision.
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This manuscript was submitted to and approved by the ethics committee of Mito Saiseikai General Hospital.
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The authors declare that they have no conflicts of interest.
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Informed consent was obtained from the patient included in the study.
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This article is part of the Topical Collection on Brain Tumors
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Watanabe, N., Ohtani, H., Mori, S. et al. Primary meningeal myxoid liposarcoma with aggressive behavior after recurrence: case report. Acta Neurochir 160, 1557–1561 (2018). https://doi.org/10.1007/s00701-018-3598-5
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Keywords
- Primary tumor
- Myxoid liposarcoma
- Intracranial
- Recurrence