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Acta Neurochirurgica

, Volume 160, Issue 6, pp 1217–1218 | Cite as

Response to the letter to the editor Systemic inflammatory response in pediatric central nervous system tumors

  • Jamie R. F. Wilson
  • Paul Chumas
  • John Goodden
  • Atul Tyagi
  • Gnanamurthy Sivakumar
Letter to the Editor (by Invitation) - Pediatric Neurosurgery
  • 41 Downloads

Dear Editor,

We thank the authors for their interest in our original submission [ 3] and the subsequent letter Systemic inflammatory response in pediatric central nervous system tumors. The authors of the letter raise numerous points regarding the methodology, which we can address in turn.
  1. 1)

    We sought to address the issue of potential confounding factors in the original article, stating that we had taken every possible step to exclude the influence of medication/steroids that may affect the values of the neutrophil-lymphocyte count ratio (NLCR). Since this was a retrospective study, there was no capacity to request additional inflammatory marker or hormonal testing on the original blood samples for each patient. The measurement of cortisol levels in the UK is not considered routine standard practice in the initial clinical assessment of children with neurological disease, and therefore, there is no capacity for this to be included in our study. However, we recognize the point made in...

References

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    Balta S, Demirkol S, Cakar M, Arslan Z, Unlu M, Celik T (2013) Other inflammatory markers should not be forgotten when assessing the neutrophil-to-lymphocyte ratio. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 19:693–694CrossRefGoogle Scholar
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    Chen M, Zheng SH, Yang M, Chen ZH, Li ST (2018) The diagnostic value of preoperative inflammatory markers in craniopharyngioma: a multicenter cohort study. J Neuro-OncolGoogle Scholar
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    Wilson JRF, Saeed F, Tyagi AK, Goodden JR, Sivakumar G, Crimmins D, Elliott M, Picton S, Chumas PD (2018) Pre-operative neutrophil count and neutrophil-lymphocyte count ratio (NLCR) in predicting the histological grade of paediatric brain tumours: a preliminary study. Acta Neurochir 160:793–800CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Jamie R. F. Wilson
    • 1
  • Paul Chumas
    • 1
  • John Goodden
    • 1
  • Atul Tyagi
    • 1
  • Gnanamurthy Sivakumar
    • 1
  1. 1.Department of NeurosurgeryThe General Infirmary at LeedsLeedsUK

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