Cerebral and spinal cavernomas associated with Klippel-Trenaunay syndrome: case report and literature review
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Klippel-Trenaunay-Weber syndrome (KTWS) involves a triad of conditions, including cutaneous hemangiomas, venous varicosities, and osseous and soft-tissue hypertrophy of the affected limb. We describe a rare case of multiple cavernomas in the central nervous system in a patient with KTWS. A-64-year-old man with KTWS and a previous brain hemorrhage presented with sudden onset of gait and vesicorectal disturbance. The magnetic resonance imaging scan showed a cavernoma associated with hemorrhage in his lumbosacral spinal cord. Moreover, numerous cavernomas were identified in his brain. He was treated conservatively with no adverse events. Gait disturbance improved, but vesicorectal disturbance did not improve.
KeywordsKlippel-Trenaunay syndrome Cavernoma Hemorrhage Vascular anomaly
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Conflicts of interest
K. Yagi has received grant support from the Japan Society for Promotion of Science and AOspine.
T. Morishita has received grant support from the Japan Society for Promotion of Science, St. Luke Life Science Institute, Nakatomi Foundation, Takeda Science Foundation, Uehara Memorial Foundation, and Central Research Institute of Fukuoka University. He has received honoraria from Boston Scientific and Medtronic as a consultant within the past 12 months.
T. Inoue has received grant support from the Clinical Research Promotion Foundation Japan and Japan Agency for Medical Research and Development.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from the individual participant included in the study.
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