Right Brodmann area 18 predicts tremor arrest after Vim radiosurgery: a voxel-based morphometry study

  • Constantin Tuleasca
  • Tatiana Witjas
  • Dimitri Van de Ville
  • Elena Najdenovska
  • Antoine Verger
  • Nadine Girard
  • Jerome Champoudry
  • Jean-Philippe Thiran
  • Meritxell Bach Cuadra
  • Marc Levivier
  • Eric Guedj
  • Jean Régis
Original Article - Functional
  • 45 Downloads

Abstract

Introduction

Drug-resistant essential tremor (ET) can benefit from open standard stereotactic procedures, such as deep-brain stimulation or radiofrequency thalamotomy. Non-surgical candidates can be offered either high-focused ultrasound (HIFU) or radiosurgery (RS). All procedures aim to target the same thalamic site, the ventro-intermediate nucleus (e.g., Vim). The mechanisms by which tremor stops after Vim RS or HIFU remain unknown. We used voxel-based morphometry (VBM) on pretherapeutic neuroimaging data and assessed which anatomical site would best correlate with tremor arrest 1 year after Vim RS.

Methods

Fifty-two patients (30 male, 22 female; mean age 71.6 years, range 49–82) with right-sided ET benefited from left unilateral Vim RS in Marseille, France. Targeting was performed in a uniform manner, using 130 Gy and a single 4-mm collimator. Neurological (pretherapeutic and 1 year after) and neuroimaging (baseline) assessments were completed. Tremor score on the treated hand (TSTH) at 1 year after Vim RS was included in a statistical parametric mapping analysis of variance (ANOVA) model as a continuous variable with pretherapeutic neuroimaging data. Pretherapeutic gray matter density (GMD) was further correlated with TSTH improvement. No a priori hypothesis was used in the statistical model.

Results

The only statistically significant region was right Brodmann area (BA) 18 (visual association area V2, p = 0.05, cluster size Kc = 71). Higher baseline GMD correlated with better TSTH improvement at 1 year after Vim RS (Spearman’s rank correlation coefficient = 0.002).

Conclusions

Routine baseline structural neuroimaging predicts TSTH improvement 1 year after Vim RS. The relevant anatomical area is the right visual association cortex (BA 18, V2). The question whether visual areas should be included in the targeting remains open.

Keywords

Tremor Ventro-intermediate nucleus Voxel-based morphometry Visual association area Radiosurgery Thalamotomy 

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2017

Authors and Affiliations

  • Constantin Tuleasca
    • 1
    • 2
    • 3
  • Tatiana Witjas
    • 4
    • 5
  • Dimitri Van de Ville
    • 6
    • 12
  • Elena Najdenovska
    • 7
  • Antoine Verger
    • 5
    • 8
    • 9
  • Nadine Girard
    • 10
  • Jerome Champoudry
    • 11
  • Jean-Philippe Thiran
    • 2
    • 3
    • 13
  • Meritxell Bach Cuadra
    • 7
  • Marc Levivier
    • 1
    • 3
  • Eric Guedj
    • 5
    • 8
    • 9
  • Jean Régis
    • 11
  1. 1.Department of Clinical Neuroscience, Neurosurgery Service and Gamma Knife CenterCentre Hospitalier Universitaire Vaudois (CHUV)LausanneSwitzerland
  2. 2.Signal Processing Laboratory (LTS 5), Ecole Polytechnique Fédérale de Lausanne (EPFL)LausanneSwitzerland
  3. 3.Faculty of Biology and MedicineUniversity of LausanneLausanneSwitzerland
  4. 4.Department of Neurology and Movement Disorders, Assistance Publique-Hôpitaux de MarseilleAix-Marseille Université, Timone University HospitalMarseilleFrance
  5. 5.Institut de Neurosciences de la Timone, UMR 7289CNRS Aix-Marseille UniversitéMarseilleFrance
  6. 6.Faculty of MedicineUniversity of GenevaGenevaSwitzerland
  7. 7.Medical Image Processing Laboratory, Ecole Polytechnique Fédérale de Lausanne (EPFL)LausanneSwitzerland
  8. 8.Radiology Department, Center for Biomedical Imaging (CIBM)Lausanne University Hospital (CHUV) and University of Lausanne (UNIL)LausanneSwitzerland
  9. 9.Department of Nuclear Medicine, Assistance Publique-Hôpitaux de MarseilleAix-Marseille Université, Timone University HospitalMarseilleFrance
  10. 10.CERIMEDAix-Marseille UniversitéMarseilleFrance
  11. 11.AMU, CRMBM UMR CNRS 7339, Faculté de Médecine et APHM, Department of Diagnostic and Interventionnal NeuroradiologyHopital TimoneMarseilleFrance
  12. 12.Stereotactic and Functional Neurosurgery Service and Gamma Knife Unit, CHU TimoneMarseilleFrance
  13. 13.Radiology DepartmentCentre Hospitalier Universitaire Vaudois (CHUV)LausanneSwitzerland

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