Acta Neurochirurgica

, Volume 159, Issue 12, pp 2319–2324 | Cite as

Disturbance of CT perfusion within 24 h after onset is associated with WFNS grade but not development of DCI in patients with aneurysmal SAH

  • Yuichi Takahashi
  • Atsushi Sasahara
  • Kei Yamazaki
  • Mayuko Inazuka
  • Hidetoshi Kasuya
Original Article - Vascular



Delayed cerebral ischemia (DCI) is a serious complication following aneurysmal SAH (aSAH) and remains a leading cause of morbidity and mortality. We investigated whether data from CT perfusion (CTP) within 24 h after onset are associated with DCI and its outcome.


We retrospectively examined plain CT, CTP, and CT angiography (CTA) of aSAH patients on arrival. We measured the average mean transit time (aMTT) and compared it with several clinical factors, such as the age, WFNS grade, Fisher group, delayed cerebral infarction, cerebral vasospasm, and modified Rankin scale (mRS), at 1 month. Regions of interest (ROIs) were quantitatively determined in cortical and two basal ganglia areas.


Delayed cerebral ischemia (DCI) developed in 11 patients and cerebral vasospasm in 28 patients out of a total of 86 aSAH patients scanned within 24 h after onset. The average MTT was correlated with the WFNS grade (p = 0.000), but not mRS (p = 0.128), age (p = 0.759), DCI (p = 0.669), or cerebral vasospasm (p = 0.306). On the other hand, DCI was associated with the Fisher group (p = 0.0056), mRS (p = 0.0052), and cerebral vasospasm (p = 0.000). Moreover, there were no significant differences in the average MTT within 24 h after onset between territories with and without DCI, or between patients with and without DCI.


The current findings suggest that disturbance of CT perfusion soon after the onset is associated with the WFNS grade but not with the development of DCI. Delayed cerebral ischemia may be solely caused by cerebral vasospasm due to a clot in the cistern, but not associated with early brain injury.


Cerebral vasospasm Delayed cerebral ischemia CT perfusion Mean transit time (MTT) 



anterior cerebral artery


average mean transit time


aneurysmal subarachnoid hemorrhage


cerebral blood flow


cerebral blood volume


computed tomography


computed tomography angiography

CT perfusion

computed tomography perfusion


delayed cerebral ischemia


intracranial pressure


middle cerebral artery


magnetic resonance imaging


modified Rankin scale


posterior cerebral artery


region of interest


World Federation of Neurosurgical Societies


Compliance with ethical standards

Conflict of interest

We declare that we have no conflict of interest.

Ethical approval

This study was approved by the institutional ethics committee of Tokyo Women’s Medical University (no. 2813). For this type of study formal consent is not required.

Informed consent

Informed consent was obtained from all individual participants included this study.


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Copyright information

© Springer-Verlag GmbH Austria 2017

Authors and Affiliations

  1. 1.Department of NeurosurgeryTokyo Women’s Medical University Medical Center EastTokyoJapan

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