Acta Neurochirurgica

, Volume 159, Issue 11, pp 2229–2233 | Cite as

Intrachiasmatic abscess caused by IgG4-related hypophysitis

  • Georgios F. Hadjigeorgiou
  • Eva Løbner Lund
  • Lars Poulsgaard
  • Ulla Feldt-Rasmussen
  • Åse Krogh Rasmussen
  • Marianne Wegener
  • Kåre Fugleholm
Case Report - Brain Tumors



Autoimmune hypophysitis is a rare disease of the pituitary, which may affect vision by inflammation and compression of the optic chiasm. However, intrachiasmatic abscess formation has not been previously reported.


In this study, we report a case of a 29-year-old female with bitemporal hemianopia due to a cystic intrasellar tumor. The patient underwent surgical decompression of the lesion, which was found to be an intrachiasmatic abscess.


The histologic findings were consistent with IgG4 hypophysitis.


This rare clinical presentation suggests that in case of a disproportionate degree of visual impairment in relation to the size of the lesion, suspicion should lead to an intrachiasmatic lesion.


Abscess Hypophysitis IgG4 Intrachiasmatic 


Compliance with ethical standards

Author disclosure statement

No competing financial interests exist.

Details of previous presentations

The content of the manuscript, all or in part, has not been published and is not being considered for publication in any form.


No funding was received for this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag GmbH Austria 2017

Authors and Affiliations

  • Georgios F. Hadjigeorgiou
    • 1
  • Eva Løbner Lund
    • 2
  • Lars Poulsgaard
    • 3
  • Ulla Feldt-Rasmussen
    • 4
  • Åse Krogh Rasmussen
    • 4
  • Marianne Wegener
    • 5
  • Kåre Fugleholm
    • 3
  1. 1.Department of Neurosurgery, Academic Hospital Munich-BogenhausenTechnical University of MunichMunichGermany
  2. 2.Department of PathologyUniversity Hospital of CopenhagenCopenhagenDenmark
  3. 3.Department of NeurosurgeryUniversity Hospital of CopenhagenCopenhagenDenmark
  4. 4.Department of EndocrinologyUniversity Hospital of CopenhagenCopenhagenDenmark
  5. 5.Department of Neuro-opthalmologyUniversity Hospital of CopenhagenCopenhagenDenmark

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