Acta Neurochirurgica

, Volume 159, Issue 3, pp 459–463 | Cite as

Brain metastasis of carcinoma ex pleomorphic adenoma of the parotid gland: case report and review of the literature

  • Ruth Lau
  • Alejandro Fernández-Coello
  • Noemí Vidal-Sarró
  • Dennis Céspedes
  • Angels Camins
  • Miren Taberna
  • Andreu Gabarrós
Case Report - Brain Tumors

Abstract

We present an extremely infrequent case of brain metastasis of a parotid tumor. To our knowledge, this is the second case reported of a brain metastasis of a malignant parotid tumor, carcinoma ex pleomorphic adenoma. Pleomorphic adenoma represents 60% of tumors of the parotid gland, and although it is a benign tumor, it can transform into carcinoma ex pleomorphic adenoma in 5% of cases, one of the most aggressive neoplasms of the salivary glands. We want to note the need for an accurate diagnostic. Thanks to aggressive surgical management, our patient survived more than 1½ years.

Keywords

Parotid tumor Brain metastasis Carcinoma ex pleomorphic adenoma 

References

  1. 1.
    Kato H, Kanematsu M, Mizuta K, Ito Y, Hirose Y (2008) Carcinoma ex pleomorphic adenoma of the parotid gland: radiologic-pathologic correlation with MR imaging including diffusion-weighted imaging. Am J Neuroradiol 29:865–867CrossRefPubMedGoogle Scholar
  2. 2.
    Lin CC, Tsai MH, Huang CC, Hua CH, Tseng HC, Huang ST (2008) Parotid tumors: a 10 year experience. American Journal of Otolaryngology-Head and Neck. Med Surg 29:94–100Google Scholar
  3. 3.
    Lingen M (2010) Head and neck: neoplasms of the salivary glands. In Robbins and Cotran (eds) Pathologic basis of diseases. Philadelphia, pp. 1478–79Google Scholar
  4. 4.
    Livolsi VA, Perzin KH (1977) Malignant mixed tumors arising in salivary glands. I. Carcinomas arising in bening mixed tumors: a clinicopathologic study. Cancer 39:2209–2230CrossRefPubMedGoogle Scholar
  5. 5.
    Nasser SM, Faquin W, Dayal Y (2003) Expression of androgen, estrogen and progesterone in receptors in salivary gland tumors. Am J Clin Pathol 119:801–806CrossRefPubMedGoogle Scholar
  6. 6.
    Olsen KD, Lewis JE (2001) Carcinoma ex pleomorphic adenoma: a clinicopathologic review. Head Neck 23(9):705–712CrossRefPubMedGoogle Scholar
  7. 7.
    Santaliz-Ruiz L, Morales G, Santini H, Sánchez-Santiago M, Arroyo A (2012) Metastasizing pleomorphic adenoma: a fascinating enigma. Case Reports in Medicine. Volume 2012, article ID 148103, 5 pagesGoogle Scholar
  8. 8.
    Sheedy SP, Welker KM, DeLone DR, Gilbertson JR (2006) CNS metastases of carcinoma ex pleomorphic adenoma of the parotid gland. Am J Neuradiol 27:1483–1485Google Scholar
  9. 9.
    Som PM, Brandwein MS (2003) Salivary glands: anatomy and pathology. In: Som PM, Curtin HD (eds) Head and Neck Imaging. Mosby, St Louis, pp 2067–2076Google Scholar
  10. 10.
    Spiro RH, Huvos AG, Strong EW (1977) Malignant mixed tumor of salivary origin: a clinicopathologic study of 146 cases. Cancer 39:388–396CrossRefPubMedGoogle Scholar
  11. 11.
    Tarakji B, Kujan O (2011) An immunohistochemical study of androgen receptor in carcinoma arising in pleomorphic salivary adenoma. Medicina Oral, patología oral y cirugía buccal 16(3):e330–e334CrossRefGoogle Scholar
  12. 12.
    Tortoledo ME, Luna MA, Batsakis JG (1984) Carcinomas ex pleomorphic adenoma and malignant mixed tumors. Histomorphologic indexes. Arch Otolaryngol 110:172–176CrossRefPubMedGoogle Scholar
  13. 13.
    Venteicher AS, Walcott BP, Sheth SA, Snuderl M, Patel Anoop P, Curry WT, Nahed B (2013) Clinical features of brain metastasis from salivary gland tumors. J Clin Neurosci 20(11):1533–1537CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Wien 2017

Authors and Affiliations

  1. 1.Neurosurgery Department, Bellvitge HospitalL’Hospitalet de LlobregatSpain
  2. 2.Anatomopathology Department, Bellvitge HospitalL’Hospitalet de LlobregatSpain
  3. 3.Neurorradiology Department, Institud de Diagnòstic per la Imatge (IDI), Bellvitge HospitalL’Hospitalet de LlobregatSpain
  4. 4.Department of Medical Oncology, IDIBELLCatalan Institute of Oncology (ICO)L’Hospitalet de LlobregatSpain
  5. 5.Cancer Epidemiology Research Program, IDIBELLCatalan Institute of Oncology (ICO)L’Hospitalet de LlobregatSpain
  6. 6.University of BarcelonaBarcelonaSpain

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