Acta Neurochirurgica

, Volume 159, Issue 2, pp 385–391 | Cite as

Radiation-induced osteosarcoma after Gamma Knife surgery for vestibular schwannoma: a case report and literature review

  • Young-Bem Se
  • Dong Gyu KimEmail author
  • Sung-Hye Park
  • Hyun-Tai Chung
Case Report - Brain Tumors


We present a rare case of radiation-induced osteosarcoma following Gamma Knife® surgery (GKS) for a vestibular schwannoma (VS). A 49-year-old female with sporadic VS underwent GKS. Serial follow-up imaging showed that the tumor size decreased. Six years after GKS, magnetic resonance imaging demonstrated regrowth of the tumor. The tumor was removed via the retrosigmoid approach. Interestingly, the final pathology report confirmed osteosarcoma arising in schwannoma with direct transition (osteosarcoma component: 90 %, schwannoma component: 10 %). The osteosarcoma was considered to be a radiation-induced malignancy. The possibility of this rare complication should be explained to the patient before GKS, and the patient should be screened periodically after GKS.


Stereotactic radiosurgery Gamma Knife radiosurgery Vestibular schwannoma Radiation-induced sarcoma Osteosarcoma 


Compliance with ethical standards


No funding was received for this research.

Conflicts of interest

The authors have no conflict of interest to disclosure.

Informed consent

The institutional review board of our institution approved this study prior to beginning this retrospective analysis. Identifying details (names, dates of birth, and other information) were not included in this study. For this type of study formal consent is not required.


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Copyright information

© Springer-Verlag Wien 2016

Authors and Affiliations

  • Young-Bem Se
    • 1
  • Dong Gyu Kim
    • 1
    Email author
  • Sung-Hye Park
    • 2
  • Hyun-Tai Chung
    • 1
  1. 1.Department of Neurosurgery, Seoul National University HospitalSeoul National University College of MedicineSeoulKorea
  2. 2.Department of Pathology, Seoul National University HospitalSeoul National University College of MedicineSeoulKorea

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