Radiation-induced osteosarcoma after Gamma Knife surgery for vestibular schwannoma: a case report and literature review
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We present a rare case of radiation-induced osteosarcoma following Gamma Knife® surgery (GKS) for a vestibular schwannoma (VS). A 49-year-old female with sporadic VS underwent GKS. Serial follow-up imaging showed that the tumor size decreased. Six years after GKS, magnetic resonance imaging demonstrated regrowth of the tumor. The tumor was removed via the retrosigmoid approach. Interestingly, the final pathology report confirmed osteosarcoma arising in schwannoma with direct transition (osteosarcoma component: 90 %, schwannoma component: 10 %). The osteosarcoma was considered to be a radiation-induced malignancy. The possibility of this rare complication should be explained to the patient before GKS, and the patient should be screened periodically after GKS.
KeywordsStereotactic radiosurgery Gamma Knife radiosurgery Vestibular schwannoma Radiation-induced sarcoma Osteosarcoma
Compliance with ethical standards
No funding was received for this research.
Conflicts of interest
The authors have no conflict of interest to disclosure.
The institutional review board of our institution approved this study prior to beginning this retrospective analysis. Identifying details (names, dates of birth, and other information) were not included in this study. For this type of study formal consent is not required.
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