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Acta Neurochirurgica

, Volume 158, Issue 3, pp 513–520 | Cite as

Trigeminal and sphenopalatine ganglion stimulation for intractable craniofacial pain—case series and literature review

  • Arsani William
  • Tej Deepak Azad
  • Eliezer Brecher
  • Taissa Cherry
  • Ivan Bernstein
  • Diana M. Bruce
  • Stacey Rohrer
  • Zachary Smith
  • Mary William
  • Eric Sabelman
  • Gary Heit
  • Patrick Pezeshkian
  • Mark SedrakEmail author
Clinical Article - Functional

Abstract

Introduction

Facial pain is often debilitating and can be characterized by a sharp, stabbing, burning, aching, and dysesthetic sensation. Specifically, trigeminal neuropathic pain (TNP), anesthesia dolorosa, and persistent idiopathic facial pain (PIFP) are difficult diseases to treat, can be quite debilitating and an effective, enduring treatment remains elusive.

Methods

We retrospectively reviewed our early experience with stimulation involving the trigeminal and sphenopalatine ganglion stimulation for TNP, anesthesia dolorosa, and PIFP between 2010–2014 to assess the feasibility of implanting at these ganglionic sites. Seven patients received either trigeminal and/or sphenopalatine ganglion stimulation with or without peripheral nerve stimulation, having failed multiple alternative modalities of treatment. The treatments were tailored on the physical location of pain to ensure regional coverage with the stimulation.

Results

Fluoroscopy or frameless stereotaxy was utilized to place the sphenopalatine and/or trigeminal ganglion stimulator. All patients were initially trialed before implantation. Trial leads implanted in the pterygopalatine fossa near the sphenopalatine ganglion were implanted via transpterygoid (lateral-medial, infrazygomatic) approach. Trial leads were implanted in the trigeminal ganglion via percutaneous Hartel approach, all of which resulted in masseter contraction. Patients who developed clinically significant pain improvement underwent implantation. The trigeminal ganglion stimulation permanent implants involved placing a grid electrode over Meckel’s cave via subtemporal craniotomy, which offered a greater ability to stimulate subdivisions of the trigeminal nerve, without muscular (V3) side effects. Two of the seven overall patients did not respond well to the trial and were not implanted. Five patients reported pain relief with up to 24-month follow-up. Several of the sphenopalatine ganglion stimulation patients had pain relief without any paresthesias. There were no electrode migrations or post-surgical complications.

Conclusions

Refractory facial pain may respond positively to ganglionic forms of stimulation. It appears safe and durable to implant electrodes in the pterygopalatine fossa via a lateral transpterygoid approach. Also, implantation of an electrode grid overlying Meckel’s cave appears to be a feasible alternative to the Hartel approach. Further investigation is needed to evaluate the usefulness of these approaches for various facial pain conditions.

Keywords

Trigeminal neuralgia Anesthesia dolorosa Persistent idiopathic facial pain Sphenopalatine ganglion 

Notes

Compliance with ethical standards

Funding

No funding was received for this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Patient consent statement

For this type of study formal consent is not required. However, the patients have consented to submission of this case series to the journal.

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Copyright information

© Springer-Verlag Wien 2016

Authors and Affiliations

  • Arsani William
    • 1
  • Tej Deepak Azad
    • 2
  • Eliezer Brecher
    • 1
  • Taissa Cherry
    • 3
  • Ivan Bernstein
    • 3
  • Diana M. Bruce
    • 3
  • Stacey Rohrer
    • 3
  • Zachary Smith
    • 4
  • Mary William
    • 3
  • Eric Sabelman
    • 3
  • Gary Heit
    • 3
  • Patrick Pezeshkian
    • 3
  • Mark Sedrak
    • 3
    Email author
  1. 1.Medical SchoolHarvard UniversityCambridgeUSA
  2. 2.Stanford University School of MedicineStanfordUSA
  3. 3.Department of NeurosurgeryKaiser Permanente-The Permanente Medical Group (TPMG)Redwood CityUSA
  4. 4.Department of NeurosurgeryNorthwestern UniversityEvanstonUSA

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