Intraoperative cerebral angiosonography with ultrasound contrast agents: how I do it
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Intraoperative vessel visualization is highly desirable, especially when the target is related to or close to main vessels, such as in the skull base and vascular surgery. Contrast-enhanced ultrasound (CEUS) is an imaging technique that allows visualization of tissue perfusion and vascularization through the infusion of purely intravascular ultrasound contrast agents (UCA).
After cerebral scanning with B-mode ultrasound (US) CEUS is performed, UCA are injected and insonated with low mechanical index US. A UCA-specific harmonic signal is transduced using a contrast-specific algorithm to obtain real-time angiosonography (ASG).
Real-time intraoperative ASG is a rapid, reliable, repeatable method for vessel visualization and evaluation of tissue perfusion.
• ASG permits to assess vessel position, dimension, and relationships; it also allows a qualitative evaluation of flow entity and direction.
• ASG shows vessels in depth without the need of their direct exposure, as for fluorescence-guided surgery.
• ASG permits to study the entire vascular tree without the necessity to set gain or pulse repetition frequency as in Doppler imaging.
• Vessels of interest can be visualized following their entire length across the surgical field, along the arterial, capillary, and venous districts.
• ASG scan is repeatable multiple times throughout the operation, and each exam could be recorded as a clip to be visualized at a later stage.
• In case of neoplastic lesion, ASG characterizes the perfusion pattern in three phases: arterial, venous, and parenchymal, permitting to visualize afferent and efferent vessels, facilitating the surgical strategy.
• During tumor debulking, ASG shows the remaining distance to major vessels, providing information to avoid direct vessel damage.
• In tumor and AVM surgery, ASG shows nidus or tumoral remnants that might be covered by healthy tissue, thus not visible on the surface.
• In case of aneurysm surgery, post-clipping angiosonographic control confirms proper aneurysm exclusion and distal vessels flow.
KeywordsIntraoperative imaging Ultrasound Contrast-enhanced ultrasound Angiography Angiosonography Vascular surgery Skull base
The authors would like to thank Mrs. Caroline King, DipArch, for her kind advice in revising the manuscript, and Luigi Solbiati M.D. and Alberto Martegani M.D. for their technical support.
The research leading to these results has received funding from the European Union Seventh Framework Programme FP7/2007–2013 under grant agreement n. 602 923.
Conflict of interest
ASG application in a case of right frontal metastasis, showing relationships between the lesion and anterior circulation arteries (MP4 46166 kb)
- 2.Piscaglia F, Nolsoe C, Dietrich CF, Cosgrove DO, Gilja OH, Bachmann Nielsen M, Albrecht T, Barozzi L, Bertolotto M, Catalano O, Claudon M, Clevert DA, Correas JM, D’Onofrio M, Drudi FM, Eyding J, Giovannini M, Hocke M, Ignee A, Jung EM, Klauser AS, Lassau N, Leen E, Mathis G, Saftoiu A, Seidel G, Sidhu PS, ter Haar G, Timmerman D, Weskott HP (2012) The EFSUMB guidelines and recommendations on the clinical practice of contrast enhanced ultrasound (CEUS): update 2011 on non-hepatic applications. Ultraschall Med 33:33–59, Stuttgart, Germany : 1980CrossRefPubMedGoogle Scholar
- 4.Prada F, Del Bene M, Mattei L, Lodigiani L, DeBeni S, Kolev V, Vetrano I, Solbiati L, Sakas G, DiMeco F (2014) Preoperative magnetic resonance and intraoperative ultrasound fusion imaging for real-time neuronavigation in brain tumor surgery. Ultraschall Med (Stuttgart, Germany: 1980)Google Scholar
- 6.Gibbs V, Cole D, Sassano A (2009) Ultrasound physics and technology. Churchill Livingstone Elsevier, LondonGoogle Scholar
- 7.EMA (2014) SonoVue -EMEA/H/C/000303 -II/0025Google Scholar
- 9.Roessler K, Krawagna M, Dörfler A, Buchfelder M, Ganslandt O (2014) Essentials in intraoperative indocyanine green videoangiography assessment for intracranial aneurysm surgery: conclusions from 295 consecutively clipped aneurysms and review of the literature. Neurosurg Focus 36:E7CrossRefPubMedGoogle Scholar