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Acta Neurochirurgica

, Volume 156, Issue 5, pp 963–969 | Cite as

The role of sympathectomy on the regulation of basilar artery volume changes in stenoocclusive carotid artery modeling after bilateral common carotid artery ligation: an animal model

  • Metehan EseogluEmail author
  • Ilhan Yilmaz
  • Mustafa Karalar
  • Mehmet Dumlu Aydin
  • Selim Kayaci
  • Cemal Gundogdu
  • Omur Gunaldi
  • Mehmet Resit Onen
Experimental research - Neurosurgery Training

Abstract

Background

Stenoocclusive carotid artery disease causes important histomorphologic changes in all craniocervical vasculatures, such as luminal enlargement, vascular wall thinning, elongation, convolutions, and aneurysm formation in the posterior circulation. Although increased pressure, retrograde blood flow, and biochemical factors are described in the pathogenesis of vascular remodelisation, the vasoregulatory role of the autonomic nervous system has not been investigated thus far. We investigated the relationship between the sympathetic nervous system and the severity of histomorphologic alterations of basilar arteries after bilateral common carotid artery ligation (BCCAL).

Material and methods

This study was conducted on 21 rabbits. The rabbits were randomly divided into three groups: baseline group (n = 5), sympathectomy non-applied group (SHAM; n = 8), and sympathectomy applied group (n = 8) before bilateral common carotid artery ligation. Permanent ligation of the prebifurcations of the common carotid arteries was performed to replicate stenoocclusive caroid artery disease. Basilar artery volumes were measured after ligation. Volumes of the basilar arteries were estimated by stereologic methods and compared between groups.

Results

Luminal enlargement, wall thinning, elongation, convolutions, and doligoectatic configurations were detected in the majority of basilar arteries. The mean basilar arterial volume was 4.27 ± 0.22 mm3 in the baseline group; 5.28 ± 0.67 mm3 in the SHAM group, and 8.84 ± 0.78 mm3 in the study group. The severity of basilar enlargement was significantly higher in the study group compared with the SHAM (p < 0.005) and baseline groups (p < 0.001).

Conclusions

Sympathectomy causes basilar artery enlargment, which is beneficial for maintaining cerebral blood flow; however, it also causes wall thinning, elongation, convolution, and aneurysm formation, which may be hazardous in stenoocclusive carotid artery disease. Sympathectomy can prevent new vessel formation and hyperthyrophic changes at the posterior circulation. Neovascularisation is not detected adequately in sympathectomised animals.

Keywords

Carotid artery Basillar artery Ligation Sympathectomy 

Notes

Conflicts of interest

None.

References

  1. 1.
    Aydin MD, Bayram E, Atalay C, Aydin N, Erdogan AR, Gundogdu C (2006) The role of neuron numbers of the petrozal ganglion in the determinetion of blood pressure. An experimental study. Minim Invasive Neurosurg 49:328–330PubMedCrossRefGoogle Scholar
  2. 2.
    Aydin MD, Ozkan U, Gündoğdu C, Onder A (2002) Protective effect of posterior cerebral circulation on carotid body ischemia. Acta Neurochir (Wien) 144(4):369–372CrossRefGoogle Scholar
  3. 3.
    Bederson JB, Levy AL, Ding WH, Kahn R, Diperna CA, Jevkins AL, Vallabhajosyula P (1998) Acute vasoconstriction after subarachnoid hemorrhage. Neurosurgery 42:352–360PubMedCrossRefGoogle Scholar
  4. 4.
    Edvinsson L, Mulder H, Goadsby PJ, Uddman R (1998) Calcitonin gene-related peptide and nitricoxide in the trigeminal ganglion: cerebral vasodilatation from trigeminal nerve stimulation involves mainly calcitonin gene-related peptide. J Auton Nerv Syst 70:15–22PubMedCrossRefGoogle Scholar
  5. 5.
    Eldawoody H, Shimizu H, Kimura N, Saito A, Nakayama T, Takahashi A, Tominaga T (2009) Simplified experimental cerebral aneurysm model in rats: comprehensive evaluation of induced aneurysms and arterial changes in the circle of Willis. Brain Res 1300:159–168PubMedCrossRefGoogle Scholar
  6. 6.
    Gao L, Hoi Y, Swartz DD, Kolega J, Siddiqui A, Meng H (2008) Nascent aneurysm formation at the basilar terminus induced by hemodynamics. Stroke 39(7):2085–2090PubMedCentralPubMedCrossRefGoogle Scholar
  7. 7.
    Goadsby PJ, Knight YE, Hoskin KL, Butler P (1997) Stimulation of an intracranial trigeminally innervated structure selectively increases cerebral blood flow. Brain Res 751:247–252PubMedCrossRefGoogle Scholar
  8. 8.
    Gundersen HJ, Bendtsen TF, Korbo L (1988) Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 96:379–394PubMedCrossRefGoogle Scholar
  9. 9.
    Hai J, Wan JF, Lin Q, Wang F, Zhang L, Li H, Zhang L, Chen YY, Lu Y (2009) Cognitive dysfunction induced by chronic cerebral hypoperfusion in a rat model associated with arteriovenous malformations. Brain Res 1301:80–88PubMedCrossRefGoogle Scholar
  10. 10.
    Hara H, Zhang QJ, Kuroyanagi T, Kobayashi S (1993) Parasympathetic cerebrovascular innervation: an anterograde tracing from the sphenopalatine ganglion in the rat. Neurosurgery 32:822–827PubMedCrossRefGoogle Scholar
  11. 11.
    Jakobsen M (1992) Role of initial brain ischemia in subarachnoid hemorrhage following aneurysm rupture: a pathophysiological survey. Acta Neurol Scand 141:133Google Scholar
  12. 12.
    Kaur G, Janik J, Isaacson LG, Callahan P (2007) Estrogen regulation of neurotrophin expression in sympathetic neurons and vascular targets. Brain Res 1139:6–14PubMedCrossRefGoogle Scholar
  13. 13.
    Kayaci S, Kanat A, Aydin MD, Musluman AM, Eseoglu M, Karalar M, Gundogdu C (2011) Role of neuron density of stellat ganglion on regulation of the basilar artery volume in subarachnoid hemorrhage: an experimental study. Auton Neurosci 165(2):163–167PubMedCrossRefGoogle Scholar
  14. 14.
    Kovacic S, Bunc G, Ravnik J (2006) Correspondence between the time course of cerebral vasospasm and the level of cerebral dopamine-beta-hydroxylase in rabbits. Auton Neurosci 130:28–31PubMedCrossRefGoogle Scholar
  15. 15.
    Lapi D, Marchiafava PL, Colantuoni A (2008) Pial microvascular responses to transient bilateral common carotid artery occlusion: effects of hypertonic glycerol. J Vasc Res 45(2):89–102PubMedCrossRefGoogle Scholar
  16. 16.
    Metaxa E, Tremmel M, Natarajan SK, Xiang J, Paluch RA, Mandelbaum M, Siddiqui AH, Kolega J, Mocco J, Meng H (2010) Characterization of critical hemodynamics contributing to aneurysmal remodeling at the basilar terminus in a rabbit model. Stroke 41(8):1774–1882PubMedCentralPubMedCrossRefGoogle Scholar
  17. 17.
    Oldendorf WH (1989) Trophic changes in the arteries at the base of the rat brain in response to bilateral common carotid ligation. J Neuropathol Exp Neurol 48:5347CrossRefGoogle Scholar
  18. 18.
    Ozkan U, Aydin MD, Gündoğdu C, Onder A (2004) Histopathologic changes in oculomotornerve and ciliary ganglion in aneurysmatic compression injuries of oculomotor nerve. Minim Invasive Neurosurg 47(2):107–110PubMedCrossRefGoogle Scholar
  19. 19.
    Shiobara R, Toya S, Mikouchi S, Izumi Z (1980) Surgery of posterior communicating artery aneurysms that enlarge after common carotid ligation. Report two cases. J Neurosurg 52:116–119PubMedCrossRefGoogle Scholar
  20. 20.
    Sterio DC (1984) The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc 134:127–136PubMedCrossRefGoogle Scholar
  21. 21.
    Suzuki N, Hardebo JE, Owman C (1990) Origin and pathways of choline acetyl transferaspositive parasympathetic nerve fibers to the cerebral vessels in rats. J Cereb Blood Flow Metab 10:399–408PubMedCrossRefGoogle Scholar
  22. 22.
    Yang DY, Pan HC, Chen CJ, Cheng FC, Wang YC (2007) Effects of tissue plasminogen activator on cerebral microvessels of rats during focal cerebral ischemia and reperfusion. Neurol Res 29(3):274–282PubMedCrossRefGoogle Scholar
  23. 23.
    Zhang QJ, Hara H, Kobayashi S (1993) Distribution patterns of sensory innervation from the trigeminal ganglion to cerebral arteries in rabbits studied by wheat germ agglutinin conjugated horse radish peroxidase anterograde tracing. Neurosurgery 32:993–999PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 2014

Authors and Affiliations

  • Metehan Eseoglu
    • 1
    • 9
    Email author
  • Ilhan Yilmaz
    • 2
  • Mustafa Karalar
    • 3
  • Mehmet Dumlu Aydin
    • 4
  • Selim Kayaci
    • 5
  • Cemal Gundogdu
    • 6
  • Omur Gunaldi
    • 7
  • Mehmet Resit Onen
    • 8
  1. 1.Department of NeurosurgeryBagcilar Medicine HospitalIstanbulTurkey
  2. 2.Department of NeurosurgerySisli Etfal Research and Training HospitalIstanbulTurkey
  3. 3.Department of NeurosurgerySilivri State HospitalIstanbulTurkey
  4. 4.Department of NeurosurgeryAtaturk Univercity Medical SchoolErzurumTurkey
  5. 5.Department of NeurosurgeryRecep Tayyip Erdogan Univercity Medical SchoolRizeTurkey
  6. 6.Department of PathologyAtaturk Univercity Medical SchoolErzurumTurkey
  7. 7.Department of NeurosurgeryBakirkoy Prof. Dr. Mazhar OSMAN Research and Training Hospital for Neurology, Neurosurgery and PsychiatryIstanbulTurkey
  8. 8.Department of NeurosurgeryÜmraniye Research and Training HospitalİstanbulTurkey
  9. 9.Department of NeurosurgeryMedicine Hospital IstanbulIstanbulTurkey

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