Acta Neurochirurgica

, Volume 155, Issue 9, pp 1601–1609 | Cite as

Endoscopic endonasal trans-sphenoidal approach for pituitary adenomas: Is one nostril enough?

  • Sheng Han
  • Xiaoxu Ding
  • Xinxin Tie
  • Yuan Liu
  • Junze Xia
  • Aihui Yan
  • Anhua Wu
Clinical Article - Brain Tumors



Over the past decade, the endoscopic endonasal trans-sphenoidal approach has been used to resect pituitary adenomas. However, in the use of this procedure, some research teams prefer a two-nostril method, whereas other groups are in favor of the one-nostril method. Here, we present a series of pituitary adenomas and try to confirm whether or not one nostril is enough for endoscopic resection of most pituitary adenomas.


A total of 250 consecutive patients who underwent an endoscopic endonasal trans-sphenoidal approach were reviewed retrospectively, of which 200 were via the unilateral nostril (group 1) and 50 were via bilateral nostrils (group 2). Surgical and clinical outcomes were analyzed.


For microadenomas, intrasellar macroadenomas and macroadenomas with moderate extrasellar extension, the prevalence of gross total resection (GTR), hormonal outcome and visual improvement were similar between the two groups. The one-nostril group had better results for duration of surgery and blood loss, with fewer rhinological complications. However, for macroadenomas with extensive extrasellar invasion, GTR was obtained in two of seven patients in group 2 but none in group 1.


The one-nostril method, which is relatively fast and minimally invasive, is adequate for endoscopic resection of most pituitary adenomas with moderate extension.


Endoscopic surgery Minimally invasive Pituitary adenoma Transsphenoidal 


Conflicts of interest



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Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Sheng Han
    • 1
  • Xiaoxu Ding
    • 2
  • Xinxin Tie
    • 1
  • Yuan Liu
    • 1
  • Junze Xia
    • 1
  • Aihui Yan
    • 2
  • Anhua Wu
    • 1
  1. 1.Department of NeurosurgeryThe First Hospital of China Medical UniversityShenyangChina
  2. 2.Department of OtorhinolaryngologyThe First Hospital of China Medical UniversityShenyangChina

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