Acta Neurochirurgica

, Volume 155, Issue 8, pp 1511–1515 | Cite as

Vascular endothelial growth factor gene polymorphisms and intracranial aneurysms

  • Marco Fontanella
  • Salvatore Gallone
  • Pier Paolo Panciani
  • Diego Garbossa
  • Roberto Stefini
  • Nicola Latronico
  • Elisa Rubino
  • Nicola Marengo
  • Alessandro Ducati
  • Lorenzo Pinessi
  • Innocenzo Rainero
Experimental Research - Vascular
First Online:
Received:
Accepted:

Abstract

Background

The exact pathophysiology of the development and rupture of saccular aneurysms is still controversial. Several lines of evidence indicate a role for inflammatory processes. Similarly, abnormal angiogenesis might be related to aneurysm growth. Expression of angiogenesis factors is higher in patients harboring aneurysms. The aim of this study was to verify the association of two functionally active polymorphisms (+ 396 C>T and 18 bp microdeletion) in the vascular endothelial growth factor (VEGF) gene with both susceptibility to and clinical features of aneurysmal subarachnoid hemorrhage (SAH) in an Italian population.

Method

Allelic and genotypic frequencies of the + 396 C>T and the 18 bp microdeletion of the VEGF gene were determined in 200 patients and 200 healthy controls.

Results

Both allelic and genotypic frequencies of the examined polymorphisms in the VEGF gene were not significantly different between cases and controls. Furthermore, the different VEGF genotypes did not seem to significantly modify the main clinical features of the disease.

Conclusions

Our data suggest that the VEGF gene is not a major genetic risk factor for aneurysmal subarachnoid hemorrhage.

Keywords

Vascular endothelial growth factor Polymorphisms Genotype Angiogenesis Aneurysmal subarachnoid hemorrhage 
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Notes

Conflicts of interest

None.

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Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Marco Fontanella
    • 1
    • 2
  • Salvatore Gallone
    • 3
  • Pier Paolo Panciani
    • 1
    • 2
  • Diego Garbossa
    • 1
  • Roberto Stefini
    • 2
  • Nicola Latronico
    • 4
  • Elisa Rubino
    • 3
  • Nicola Marengo
    • 1
  • Alessandro Ducati
    • 1
  • Lorenzo Pinessi
    • 3
  • Innocenzo Rainero
    • 3
  1. 1.Department of Neuroscience, Division of NeurosurgeryUniversity of TurinTurinItaly
  2. 2.Department of Neuroscience, Division of NeurosurgeryUniversity of BresciaBresciaItaly
  3. 3.Department of Neuroscience, Division of NeurologyUniversity of TurinTurinItaly
  4. 4.Department of Neuroanesthesia-Neurointensive CareUniversity of BresciaBresciaItaly

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