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Acta Neurochirurgica

, Volume 154, Issue 12, pp 2241–2249 | Cite as

Higher incidence of epilepsy in meningiomas located on the premotor cortex: a voxel-wise statistical analysis

  • Tadashi HamasakiEmail author
  • Kazumichi Yamada
  • Shigetoshi Yano
  • Hideo Nakamura
  • Keishi Makino
  • Taku-ichiro Hide
  • Yu Hasegawa
  • Jun-ichiro Kuroda
  • Toshinori Hirai
  • Jun-ichi Kuratsu
Clinical Article

Abstract

Background

A substantial number of patients with brain tumors develop recurrent seizures, known as tumor-associated epilepsy. It is important to identify specific subgroups of brain tumor patients with higher incidences of epilepsy because a meta-analysis failed to certify the effectiveness of prophylactic anti-epileptic drugs (AEDs) to abort tumor-associated epilepsy as a whole.

Methods

To investigate the relationship between tumor location and incidence of epilepsy, we performed voxel-wise comparison between 3D MRI scans obtained from patients with meningioma-associated epilepsy and those from control patients using spatial normalization techniques on neuroimaging data. Variables such as age, tumor size, the degree of edema, and pathological diagnosis were also compared between the two groups.

Results

Our results showed the highest incidence of epilepsy when the tumor was located on the premotor cortex in the frontal lobe (Z-scores >2.0, Liebermeister’s quasi-exact test). The stepwise multiple regression analysis on the clinical data revealed that the tumor diameter (p < 0.001) and the patient’s age (p = 0.024) were positive and negative predictors, respectively, for the onset of epilepsy.

Conclusions

The incidence of epilepsy was higher in meningiomas located on the premotor cortex than on the other cortex. Larger volume also contributed to the onset of epilepsy. We suggest that variations of epilepsy incidence dependent on tumor characteristics can be considered when treating tumor-associated epilepsy.

Keywords

Epilepsy Lesion-symptom mapping Meningioma Voxel-wise analysis 

Notes

Acknowledgments

This work was supported in part by a research grant to T.H. from The Japan Spina Bifida & Hydrocephalus Research Foundation.

Conflicts of interest

None

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Copyright information

© Springer-Verlag Wien 2012

Authors and Affiliations

  • Tadashi Hamasaki
    • 1
    • 3
    Email author
  • Kazumichi Yamada
    • 1
  • Shigetoshi Yano
    • 1
  • Hideo Nakamura
    • 1
  • Keishi Makino
    • 1
  • Taku-ichiro Hide
    • 1
  • Yu Hasegawa
    • 1
  • Jun-ichiro Kuroda
    • 1
  • Toshinori Hirai
    • 2
  • Jun-ichi Kuratsu
    • 1
  1. 1.Department of NeurosurgeryKumamoto University HospitalKumamotoJapan
  2. 2.Department of Diagnostic ImagingKumamoto University HospitalKumamotoJapan
  3. 3.Laboratory for Neurosciences Department of NeurosurgeryKumamoto University HospitalKumamotoJapan

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