Acta Neurochirurgica

, Volume 152, Issue 9, pp 1583–1590 | Cite as

Curcumin improves early functional results after experimental spinal cord injury

  • Berker Cemil
  • Kivanc Topuz
  • Mehmet Nusret Demircan
  • Gokhan Kurt
  • Kagan Tun
  • Murat Kutlay
  • Osman Ipcioglu
  • Zafer Kucukodaci
Experimental research



Curcumin is a polyphenol extracted from the rhizome of Curcuma longa and well known as a multifunctional drug with anti-oxidative, anticancerous, and anti-inflammatory activities. The aim of the study was to evaluate and compare the effects of the use of the curcumin and the methylprednisolone sodium succinate (MPSS) functionally, biochemically, and pathologically after experimental spinal cord injury (SCI).


Forty rats were randomly allocated into five groups. Group 1 was performed only laminectomy. Group 2 was introduced 70-g closing force aneurysm clip injury. Group 3 was given 30 mg/kg MPSS intraperitoneally immediately after the trauma. Group 4 was given 200 mg/kg of curcumin immediately after the trauma. Group 5 was the vehicle, and immediately after trauma, 1 mL of rice bran oil was injected. The animals were examined by inclined plane score and Basso–Beattie–Bresnahan scale 24 h after the trauma. At the end of the experiment, spinal cord tissue samples were harvested to analyze tissue concentrations of malondialdehyde (MDA) levels, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) activity, and catalase (CAT) activity and pathological evaluation.


Curcumin treatment improved neurologic outcome, which was supported by decreased level of tissue MDA and increased levels of tissue GSH-Px, SOD, and CAT activity. Light microscopy results also showed preservation of tissue structure in the treatment group.


This study showed the neuroprotective effects of curcumin on experimental SCI model. By increasing tissue levels of GSH-Px, SOD, and CAT, curcumin seems to reduce the effects of injury to the spinal cord, which may be beneficial for neuronal survival.


Curcumin Methylprednisolone Neuroprotection Oxygen-free radical Spinal cord injury 



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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Berker Cemil
    • 1
  • Kivanc Topuz
    • 2
  • Mehmet Nusret Demircan
    • 2
  • Gokhan Kurt
    • 3
  • Kagan Tun
    • 4
  • Murat Kutlay
    • 2
  • Osman Ipcioglu
    • 5
  • Zafer Kucukodaci
    • 6
  1. 1.Department of Neurosurgery, Faculty of MedicineFatih UniversityAnkaraTurkey
  2. 2.Department of Neurosurgery, Haydarpasa Training HospitalGulhane Military Medical AcademyIstanbulTurkey
  3. 3.Department of NeurosurgeryGazi UniversityAnkaraTurkey
  4. 4.Department of NeurosurgeryAnkara Numune Education and Research HospitalAnkaraTurkey
  5. 5.Department of Biochemistry, Haydarpasa Training HospitalGulhane Military Medical AcademyIstanbulTurkey
  6. 6.Department of Pathology, Haydarpasa Training HospitalGulhane Military Medical AcademyIstanbulTurkey

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