Acta Neurochirurgica

, Volume 152, Issue 8, pp 1425–1429 | Cite as

Leptomeningeal dissemination of a pediatric neoplasm with 1p19q deletion showing mixed immunohistochemical features of an oligodendroglioma and neurocytoma

  • Richard B. Rhiew
  • Sunil Manjila
  • Andrew Lozen
  • Murali Guthikonda
  • Sandeep Sood
  • William J. Kupsky
Case Report


Leptomeningeal dissemination of an oligodendroglioma is rarely reported in the neurosurgical literature, especially in cases with a classical 1p19q deletion. The authors describe a case wherein a 1p19q deletion in a disseminated tumor with mixed immunohistochemical features of oligodendroglioma and neurocytoma was encountered and treated. Stereotactic right frontal craniotomy was undertaken for obtaining definitive histological diagnosis. The results revealed a neuroectodermal neoplasm with histologic and immunohistochemical features of oligodendroglioma and neurocytoma. FISH analysis confirmed classical 1p19q deletion. The patient was treated postoperatively with chemotherapy and radiation therapy. He showed good clinical response and remains alive 16 months after diagnosis.


Leptomeningeal dissemination Oligodenroglioma Neurocytoma Mixed tumor 



Special thanks to Dr. Peter Burger (Johns Hopkins Univ.) and Dr. Paul McKeever (Univ. of Michigan—Ann Arbor) for serving as neuropathology experts in the review of histologic preparations.


  1. 1.
    Ando K, Ishikura R, Morika T, Nakao N, Matsumoto T, Arita N (2002) Central neurocytoma with craniospinal dissemination. Magn Reson Med Sci 1(3):179–182PubMedCrossRefGoogle Scholar
  2. 2.
    Armaoa DM, Stonea J, Castillo M, Mitchella KM, Bouldina TW, Suzukia K (2000) Diffuse leptomeningeal oligodendrogliomatosis: radiologic/pathologic correlation. Am J Neuroradiol 21:1122–1126Google Scholar
  3. 3.
    Bailey P, Cushing H (1926) A classification of the tumors of the glioma group on a histogenetic basis with a correlated study of prognosis. Lippincott, PhiladelphiaGoogle Scholar
  4. 4.
    Beck DJK, Russell DS (1942) Oligodendrogliomatosis of the cerebrospinal fluid pathway. Brain 65:352–372CrossRefGoogle Scholar
  5. 5.
    Bharny D, Murphy GM, Horenstein S, Silbert SW (1974) Diffuse periventricular and meningeal glioma. Acta Neuropathol 30(3):243–249CrossRefGoogle Scholar
  6. 6.
    Cairncross JG, Ueki K, Zlatescu MC, Lisle DK, Finkelstein DM, Hammond RR, Silver JS, Stark PC, Macdonald DR, Ino Y, Ramsay DA, Louis DN (1998) Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J Natl Cancer Inst 7;90(19):1473–1479Google Scholar
  7. 7.
    Cooper IS, Kernohan JW (1951) Heterotopic glial nests in the subarachnoid space; histopathologic characteristics, mode of origin and relation to meningeal gliomas. J Neuropathol Exp Neurol 10(1):16–29PubMedGoogle Scholar
  8. 8.
    Eberth CJ (1970) Zur Entwicklung des Epitheliomas dur Pia under der Lung. Virchow’s Arch 49:51–63CrossRefGoogle Scholar
  9. 9.
    Eng DY, DeMonte F, Ginsberg L, Fuller GN, Jaeckle K (1997) Craniospinal dissemination of central neurocytoma. Report of two cases. J Neurosurg 86(3):547–552PubMedCrossRefGoogle Scholar
  10. 10.
    Horoupian DS, Lax F, Suzuki K (1979) Extracerebral leptomeningeal astrocytoma mimicking a meningioma. Arch Pathol Lab Med 103(13):676–679PubMedGoogle Scholar
  11. 11.
    Mrak RE, Yasargil MG, Mohapatra G, Earel J Jr, Louis DN (2004) Atypical neurocytoma with oligodendroglioma-like spread and an unusual pattern of chromosome 1p and 19q loss. Hum Pathol 35(9):1156–1159PubMedCrossRefGoogle Scholar
  12. 12.
    Perilongo G, Gardiman M, Bisaglia L, Rigobello L, Calderone M, Battistella A, Burnelli R, Giangaspero F (2002) Spinal low-grade neoplasms with extensive leptomeningeal dissemination in children. Childs Nerv Syst 18(9-10):505–512, Epub 2002 Aug 17PubMedCrossRefGoogle Scholar
  13. 13.
    Perilongo G, Garre ML, Giangaspero F (2003) Low-grade gliomas and leptomeningeal dissemination: a poorly understood phenomenon. Childs Nerv Syst 19(4):197–203PubMedGoogle Scholar
  14. 14.
    Perry A, Scheithauer BW, Macaulay RJ, Raffel C, Roth KA, Kros JM (2002) Oligodendrogliomas with neurocytic differentiation. A report of 4 cases with diagnostic and histogenetic implications. J Neuropathol Exp Neurol 61(11):947–955PubMedGoogle Scholar
  15. 15.
    Polmeteer FE, Kernohan JW (1947) Meningeal gliomatosis. A study of forty-two cases. Arch Neurol Psychiatry 57:593–616PubMedGoogle Scholar
  16. 16.
    Preusser M, Budka H, Rössler K, Hainfellner JA (2007) OLIG2 is a useful immunohistochemical marker in differential diagnosis of clear cell primary CNS neoplasms. Histopathology 50(3):365–370PubMedCrossRefGoogle Scholar
  17. 17.
    Psarros TG, Mulne SD, AF BDK (2005) Neurocytoma-like neoplasm of the thorasic spine in a 15 month-old child presenting with diffuse leptomeningeal dissemination and communicating hydrocephalus. Case report. J Neurosurg 103(2 Suppl):184–190PubMedGoogle Scholar
  18. 18.
    Takao H, Nakagawa K, Ohtomo K (2003) Central neurocytoma with craniospinal dissemination. J Neuro-oncol 61(3):255–259CrossRefGoogle Scholar
  19. 19.
    Wolbach S (1907) Congenital rhabdomyoma of the heart: report of a case associated with multiple nests of neuroglial tissue in the meninges of the spinal cord. J Med Res 16:495–519PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Richard B. Rhiew
    • 1
  • Sunil Manjila
    • 1
  • Andrew Lozen
    • 2
  • Murali Guthikonda
    • 1
  • Sandeep Sood
    • 3
  • William J. Kupsky
    • 4
  1. 1.Department of NeurosurgeryWayne State University School of MedicineDetroitUSA
  2. 2.Department of NeurosurgeryMedical College of Wisconsin & Froedtert HospitalMilwaukeeUSA
  3. 3.Department of Pediatric NeurosurgeryChildren’s Hospital of MichiganDetroitUSA
  4. 4.Department of PathologyWayne State University School of MedicineDetroitUSA

Personalised recommendations