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Acta Neurochirurgica

, Volume 152, Issue 4, pp 605–610 | Cite as

Radiosurgery for brain metastasis from advanced gastric cancer

  • Jung Ho Han
  • Dong Gyu KimEmail author
  • Hyun-Tai Chung
  • Chae-Yong Kim
  • Chul-Kee Park
  • Young Seob Chung
  • Sun Ha Paek
  • Moon-Won Yoo
  • Baek-Hui Kim
  • Hee-Won Jung
Clinical Article

Abstract

Purpose

We retrospectively evaluated the survival of patients with brain metastases from advanced gastric cancer (AGC) after radiosurgery (RS).

Methods

Between 1998 and 2007, a total of 11 patients (median age, 61 years; range, 36–70) were diagnosed with brain metastasis from AGC and treated with RS. Each of five (46%) patients had two brain metastases. The median volume of the 16 lesions was 2.9 cm3 (range, 0.1–33.8). The median marginal dose prescribed was 20 Gy (range, 10–25) at the 50% isodose line. RS was the primary treatment for brain metastases in six patients.

Results

As of February 28, 2008, eight (73%) patients had died, and three (27%) were living with stable disease. The median survival time was 17.0 ± 3.9 months (95% CI, 9.4–24.6). The median progression-free survival time was 9.0 ± 2.5 months (95% CI, 4.2–13.8). Patients who did not undergo WBRT died within 8 months, and the other six patients treated with WBRT at various time intervals from the diagnosis of brain metastases survived, with a median survival time of 19.0 ± 3.4 months (95% CI, 12.4–25.6).

Conclusions

Radiosurgery seems to be a good alternative to surgical resection for patients with brain metastases from AGC, when performed in conjunction with WBRT.

Keywords

Brain metastasis Advanced gastric carcinoma Gamma Knife radiosurgery Whole-brain radiotherapy 

Notes

Acknowledgement

This study was supported by grant no. 11-2008-027 from the SNUBH Research fund and was partially supported by Nuclear Research & Development Program of the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean government (MEST) (grant no. M20090078163). The statistical analysis was supported by the Medical Research Collaborating Center, Seoul National University Hospital.

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Jung Ho Han
    • 4
  • Dong Gyu Kim
    • 1
    Email author
  • Hyun-Tai Chung
    • 1
  • Chae-Yong Kim
    • 1
  • Chul-Kee Park
    • 1
  • Young Seob Chung
    • 1
  • Sun Ha Paek
    • 1
  • Moon-Won Yoo
    • 2
  • Baek-Hui Kim
    • 3
  • Hee-Won Jung
    • 1
  1. 1.Department of NeurosurgerySeoul National University College of MedicineSeoulKorea
  2. 2.Department of SurgeryKonkuk University School of MedicineSeoulKorea
  3. 3.Department of PathologyKorea University College of MedicineSeoulKorea
  4. 4.Department of NeurosurgerySeoul National University Bundang HospitalGyeonggi-doKorea

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