Acta Neurochirurgica

, 151:1359 | Cite as

Long-term outcome and survival of surgically treated supratentorial low-grade glioma in adult patients

  • Ahmadi Rezvan
  • Dictus Christine
  • Hartmann Christian
  • Zürn Olga
  • Edler Lutz
  • Hartmann Marius
  • Combs Stephanie
  • Herold-Mende Christel
  • Wirtz Christian Rainer
  • Unterberg Andreas
Clinical Article



The appropriate management of low-grade gliomas is still a matter of debate. So far, there are no randomized studies that analyze the impact of surgical resection on patient outcome. The value of the data obtained from the few retrospective reports available is often limited.

Patients and methods

In the present study, we performed an analysis on data of 130 adult low-grade glioma patients. Extent of the resection was evaluated in correlation to the overall survival (OS) and progression-free survival (PFS) using Cox regression multivariate analysis.


Extended surgery was shown to prolong OS and PFS significantly. Re-surgery in the case of a tumor relapse has a significant impact on OS and PFS, too.


In summary, we could retrospectively evaluate a large case series of well-defined low-grade gliomas patients with a long follow-up period showing that extended surgery would be the most effective therapy for low-grade glioma patients even in recurrent diseases.


Low-grade glioma Extent of surgery Survival 



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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Ahmadi Rezvan
    • 1
  • Dictus Christine
    • 1
  • Hartmann Christian
    • 2
  • Zürn Olga
    • 1
  • Edler Lutz
    • 3
  • Hartmann Marius
    • 4
  • Combs Stephanie
    • 5
  • Herold-Mende Christel
    • 1
  • Wirtz Christian Rainer
    • 1
  • Unterberg Andreas
    • 1
  1. 1.Department of NeurosurgeryUniversity of HeidelbergHeidelbergGermany
  2. 2.Clinical cooperation unit of Neuropathology, German Cancer Research CenterHeidelbergGermany
  3. 3.Institute of Biostatistics, German Cancer Research CenterHeidelbergGermany
  4. 4.Department of NeuroradiologyUniversity of HeidelbergHeidelbergGermany
  5. 5.Department of Radiation OncologyUniversity of HeidelbergHeidelbergGermany

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