Acta Neurochirurgica

, Volume 151, Issue 8, pp 873–900

Hemostatic and hemorrhagic problems in neurosurgical patients

  • Ruediger Gerlach
  • Manuela Krause
  • Volker Seifert
  • Klaus Goerlinger
Review Article

Abstract

Background

Abnormalities of the hemostasis can lead to hemorrhage, and on the other hand to thrombosis. Intracranial neoplasms, complex surgical procedures, and head injury have a specific impact on coagulation and fibrinolysis. Moreover, the number of neurosurgical patients on medication (which interferes with platelet function and/or the coagulation systems) has increased over the past years.

Method

The objective of this review is to recall common hemostatic disorders in neurosurgical patients on the basis of the “new concept of hemostasis”. Therefore the pertinent literature was searched to provide a structured and up to date manuscript about hemostasis in Neurosurgery.

Findings

According to recent scientific publications abnormalities of the coagulation system are discussed. Pathophysiological background and the rational for specific (cost)-effective perioperative hemostatic therapy is provided.

Conclusions

Perturbations of hemostasis can be multifactorial and maybe encountered in the daily practice of neurosurgery. Early diagnosis and specific treatment is the prerequisite for successful treatment and good patients outcome.

Keywords

Hemorrhagic disorders Postoperative hemorrhage Coagulopathy Fibrinolysis DIC Thrombosis Head injury 

References

  1. 1.
    Abrahams JM, Torchia MB, McGarvey M, Putt M, Baranov D, Sinson GP (2002) Perioperative assessment of coagulability in neurosurgical patients using thromboelastography. Surg Neurol 58:5–11PubMedGoogle Scholar
  2. 2.
    Agnelli G, Piovella F, Buoncristiani P, Severi P, Pini M, D’Angelo A, Beltrametti C, Damiani M, Andrioli GC, Pugliese R, Iorio A, Brambilla G (1998) Enoxaparin plus compression stockings compared with compression stockings alone in the prevention of venous thromboembolism after elective neurosurgery. N Engl J Med 339:80–85PubMedGoogle Scholar
  3. 3.
    Albanese A, Tuttolomondo A, Anile C, Sabatino G, Pompucci A, Pinto A, Licata G, Mangiola A (2005) Spontaneous chronic subdural hematomas in young adults with a deficiency in coagulation factor XIII. Report of three cases. J Neurosurg 102:1130–1132PubMedGoogle Scholar
  4. 4.
    Aldouri M (2002) The use of recombinant factor VIIa in controlling surgical bleeding in non-haemophiliac patients. Pathophysiol Haemost Thromb 32(Suppl 1):41–46PubMedGoogle Scholar
  5. 5.
    Anderson L, Quasim I, Soutar R, Steven M, Macfie A, Korte W (2006) An audit of red cell and blood product use after the institution of thromboelastometry in a cardiac intensive care unit. Transfus Med 16:31–39PubMedGoogle Scholar
  6. 6.
    Arai Y, Kubota T, Nakagawa T, Kabuto M, Sato K, Kobayashi H (1998) Production of urokinase-type plasminogen activator (u-PA) and plasminogen activator inhibitor-1 (PAI-1) in human brain tumours. Acta Neurochir (Wien) 140:377–385Google Scholar
  7. 7.
    Astrup T (1965) Assay and content of tissue thromboplastin in different organs. Thromb Diath Haemorrh 14:401–416PubMedGoogle Scholar
  8. 8.
    Auguste KI, Quinones-Hinojosa A, Berger MS (2004) Efficacy of mechanical prophylaxis for venous thromboembolism in patients with brain tumors. Neurosurg Focus 17:E3PubMedGoogle Scholar
  9. 9.
    Auguste KI, Quinones-Hinojosa A, Gadkary C, Zada G, Lamborn KR, Berger MS (2003) Incidence of venous thromboembolism in patients undergoing craniotomy and motor mapping for glioma without intraoperative mechanical prophylaxis to the contralateral leg. J Neurosurg 99:680–684PubMedGoogle Scholar
  10. 10.
    Baglin TP, Keeling DM, Watson HG (2006) Guidelines on oral anticoagulation (warfarin): third edition–2005 update. Br J Haematol 132:277–285PubMedGoogle Scholar
  11. 11.
    Barnett HG, Clifford JR, Llewellyn RC (1977) Safety of mini-dose heparin administration for neurosurgical patients. J Neurosurg 47:27–30PubMedGoogle Scholar
  12. 12.
    bdel-Wahab OI, Healy B, Dzik WH (2006) Effect of fresh-frozen plasma transfusion on prothrombin time and bleeding in patients with mild coagulation abnormalities. Transfusion 46:1279–1285Google Scholar
  13. 13.
    Becker S, Schneider W, Kreuz W, Jacobi G, Scharrer I, Nowak-Gottl U (1999) Post-trauma coagulation and fibrinolysis in children suffering from severe cerebro-cranial trauma. Eur J Pediatr 158(Suppl 3):S197–S202PubMedGoogle Scholar
  14. 14.
    Benzer H, Blümel G, Brenner H (1963) Ueber Blutgerinnungsstörungen nach Hirnverletzungen und Hirnverletzungen. Wien Klin Wochenschr 75:725–726PubMedGoogle Scholar
  15. 15.
    Berger MM, Ravussin P, Vielle G, Fankhauser H (1995) Life-threatening hemorrhagic diathesis due to disseminated intravascular coagulation during elective brain tumor surgery. J Neurosurg Anesthesiol 7:26–29PubMedGoogle Scholar
  16. 16.
    Bernstein DE, Jeffers L, Erhardtsen E, Reddy KR, Glazer S, Squiban P, Bech R, Hedner U, Schiff ER (1997) Recombinant factor VIIa corrects prothrombin time in cirrhotic patients: a preliminary study. Gastroenterology 113:1930–1937PubMedGoogle Scholar
  17. 17.
    Black PM, Baker MF, Snook CP (1986) Experience with external pneumatic calf compression in neurology and neurosurgery. Neurosurgery 18:440–444PubMedGoogle Scholar
  18. 18.
    Boffard KD, Riou B, Warren B, Choong PI, Rizoli S, Rossaint R, Axelsen M, Kluger Y (2005) Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled, double-blind clinical trials. J Trauma 59:8–15PubMedGoogle Scholar
  19. 19.
    Bohrer H (1999) Prothrombin complex concentrate substitution during liver transplantation. Thromb Res 95:S71–S74PubMedGoogle Scholar
  20. 20.
    Bonnemaison J, Thicoipe M, Dixmerias F, Guerin V (1998) Coagulopathy suggestive of a primary fibrinolysis after head injuries with brain death. Ann Fr Anesth Reanim 17:275–277PubMedGoogle Scholar
  21. 21.
    Bostrom S, Holmgren E, Jonsson O, Lindberg S, Lindstrom B, Winso I, Zachrisson B (1986) Post-operative thromboembolism in neurosurgery. A study on the prophylactic effect of calf muscle stimulation plus dextran compared to low-dose heparin. Acta Neurochir (Wien) 80:83–89Google Scholar
  22. 22.
    Boulis NM, Bobek MP, Schmaier A, Hoff JT (1999) Use of factor IX complex in warfarin-related intracranial hemorrhage. Neurosurgery 45:1113–1118PubMedGoogle Scholar
  23. 23.
    Bratton SL, Chestnut RM, Ghajar J, Connell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW (2007) Guidelines for the management of severe traumatic brain injury. V. Deep vein thrombosis prophylaxis. J Neurotrauma 24(Suppl 1):S32–S36PubMedGoogle Scholar
  24. 24.
    Brody DL, Aiyagari V, Shackleford AM, Diringer MN (2005) Use of recombinant factor VIIa in patients with warfarin-associated intracranial hemorrhage. Neurocrit Care 2:263–267PubMedGoogle Scholar
  25. 25.
    Brohi K, Cohen MJ, Davenport RA (2007) Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care 13:680–685PubMedGoogle Scholar
  26. 26.
    Browd SR, Ragel BT, Davis GE, Scott AM, Skalabrin EJ, Couldwell WT (2004) Prophylaxis for deep venous thrombosis in neurosurgery: a review of the literature. Neurosurg Focus 17:E1PubMedGoogle Scholar
  27. 27.
    Brown JR, Birkmeyer NJ, O’Connor GT (2007) Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery. Circulation 115:2801–2813PubMedGoogle Scholar
  28. 28.
    Brozna JP (1990) Cellular regulation of tissue factor. Blood Coagul Fibrinolysis 1:415–426PubMedGoogle Scholar
  29. 29.
    Brummel-Ziedins K, Whelihan MF, Ziedins EG, Mann KG (2006) The resuscitative fluid you choose may potentiate bleeding. J Trauma 61:1350–1358PubMedGoogle Scholar
  30. 30.
    Bucci MN, Papadopoulos SM, Chen JC, Campbell JA, Hoff JT (1989) Mechanical prophylaxis of venous thrombosis in patients undergoing craniotomy: a randomized trial. Surg Neurol 32:285–288PubMedGoogle Scholar
  31. 31.
    Bullock MR, Chesnut R, Ghajar J, Gordon D, Hartl R, Newell DW, Servadei F, Walters BC, Wilberger J (2006) Surgical management of traumatic parenchymal lesions. Neurosurgery 58:S25–S46PubMedGoogle Scholar
  32. 32.
    Bullock MR, Chesnut R, Ghajar J, Gordon D, Hartl R, Newell DW, Servadei F, Walters BC, Wilberger JE (2006) Surgical management of acute epidural hematomas. Neurosurgery 58:S7–15PubMedGoogle Scholar
  33. 33.
    Bullock R, Hanemann CO, Murray L, Teasdale GM (1990) Recurrent hematomas following craniotomy for traumatic intracranial mass. J Neurosurg 72:9–14PubMedGoogle Scholar
  34. 34.
    Cannizzaro E, Albisetti M, Wohlrab G, Schmugge M (2007) Severe bleeding complications during antiepileptic treatment with valproic acid in children. Neuropediatrics 38:42–45PubMedGoogle Scholar
  35. 35.
    Carrick MM, Tyroch AH, Youens CA, Handley T (2005) Subsequent development of thrombocytopenia and coagulopathy in moderate and severe head injury: support for serial laboratory examination. J Trauma 58:725–729PubMedGoogle Scholar
  36. 36.
    Casbard AC, Williamson LM, Murphy MF, Rege K, Johnson T (2004) The role of prophylactic fresh-frozen plasma in decreasing blood loss and correcting coagulopathy in cardiac surgery. A systematic review. Anaesthesia 59:550–558PubMedGoogle Scholar
  37. 37.
    Cermelj M, Negro F, Schijman E, Ferro AM, Acerenza M, Pollola J (2004) Neurosurgical intervention in a haemophilic child with a subdural and intracerebral haematoma. Haemophilia 10:405–407PubMedGoogle Scholar
  38. 38.
    Cerrato D, Ariano C, Fiacchino F (1978) Deep vein thrombosis and low-dose heparin prophylaxis in neurosurgical patients. J Neurosurg 49:378–381PubMedGoogle Scholar
  39. 39.
    Chan KH, Mann KS, Chan TK (1989) The significance of thrombocytopenia in the development of postoperative intracranial hematoma. J Neurosurg 71:38–41PubMedGoogle Scholar
  40. 40.
    Charbit B, Mandelbrot L, Samain E, Baron G, Haddaoui B, Keita H, Sibony O, Mahieu-Caputo D, Hurtaud-Roux MF, Huisse MG, Denninger MH, de PD (2007) The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage. J Thromb Haemost 5:266–273PubMedGoogle Scholar
  41. 41.
    Chowdhury P, Saayman AG, Paulus U, Findlay GP, Collins PW (2004) Efficacy of standard dose and 30 ml/kg fresh-frozen plasma in correcting laboratory parameters of haemostasis in critically ill patients. Br J Haematol 125:69–73PubMedGoogle Scholar
  42. 42.
    Churliaev IuA, Lychev VG, Epifantseva NN, Redkokasha LIu (1999) [Clinico-pathogenetic variants of DIC syndrome in patients with severe craniocerebral trauma]. Anesteziol Reanimatol (6):27–29Google Scholar
  43. 43.
    Claes Y, Van Hemelrijck J, Van Gerven M, Arnout J, Vermylen J, Weidler B, Van Aken H (1992) Influence of hydroxyethyl starch on coagulation in patients during the perioperative period. Anesth Analg 75:24–30PubMedGoogle Scholar
  44. 44.
    Cohen MJ, Brohi K, Ganter MT, Manley GT, Mackersie RC, Pittet JF (2007) Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway. J Trauma 63:1254–1261PubMedGoogle Scholar
  45. 45.
    Conroy JM, Fishman RL, Reeves ST, Pinosky ML, Lazarchick J (1996) The effects of desmopressin and 6% hydroxyethyl starch on factor VIII:C. Anesth Analg 83:804–807PubMedGoogle Scholar
  46. 46.
    Contreras M (1998) Consensus conference on platelet transfusion. Final statement. Transfus Sci 19:111–114PubMedGoogle Scholar
  47. 47.
    Cothren CC, Smith WR, Moore EE, Morgan SJ (2007) Utility of once-daily dose of low-molecular-weight heparin to prevent venous thromboembolism in multisystem trauma patients. World J Surg 31:98–104PubMedGoogle Scholar
  48. 48.
    Cravens GT, Brown MJ, Brown DR, Wass CT (2006) Antifibrinolytic therapy use to mitigate blood loss during staged complex major spine surgery: Postoperative visual color changes after tranexamic acid administration. Anesthesiology 105:1274–1276PubMedGoogle Scholar
  49. 49.
    Cronberg S, Wallmark E, Soderberg I (1984) Effect on platelet aggregation of oral administration of 10 non-steroidal analgesics to humans. Scand J Haematol 33:155–159PubMedGoogle Scholar
  50. 50.
    Da’as N, Misgav M, Kalish Y, Varon D (2006) Recombinant factor VIIa for rapid reversal of anticoagulant effect in patients with intracranial hemorrhage: the Israeli experience and review of the literature. Isr Med Assoc J 8:807–811PubMedGoogle Scholar
  51. 51.
    Dara SI, Rana R, Afessa B, Moore SB, Gajic O (2005) Fresh-frozen plasma transfusion in critically ill medical patients with coagulopathy. Crit Care Med 33:2667–2671PubMedGoogle Scholar
  52. 52.
    Dasta JF, McLaughlin TP, Mody SH, Piech CT (2005) Daily cost of an intensive care unit day: the contribution of mechanical ventilation. Crit Care Med 33:1266–1271PubMedGoogle Scholar
  53. 53.
    de Jonge E, Levi M, Buller HR, Berends F, Kesecioglu J (2001) Decreased circulating levels of von Willebrand factor after intravenous administration of a rapidly degradable hydroxyethyl starch (HES 200/0.5/6) in healthy human subjects. Intensive Care Med 27:1825–1829PubMedGoogle Scholar
  54. 54.
    Deloughery TG (2004) Coagulation defects in trauma patients: etiology, recognition, and therapy. Crit Care Clin 20:13–24PubMedGoogle Scholar
  55. 55.
    Despotis GJ, Goodnough LT (2000) Management approaches to platelet-related microvascular bleeding in cardiothoracic surgery. Ann Thorac Surg 70:S20–S32PubMedGoogle Scholar
  56. 56.
    Deveras RA, Kessler CM (2002) Reversal of warfarin-induced excessive anticoagulation with recombinant human factor VIIa concentrate. Ann Intern Med 137:884–888PubMedGoogle Scholar
  57. 57.
    Dickinson LD, Miller LD, Patel CP, Gupta SK (1998) Enoxaparin increases the incidence of postoperative intracranial hemorrhage when initiated preoperatively for deep venous thrombosis prophylaxis in patients with brain tumors. Neurosurgery 43:1074–1081PubMedGoogle Scholar
  58. 58.
    Diringer MN, Skolnick BE, Mayer SA, Steiner T, Davis SM, Brun NC, Broderick JP (2008) Risk of thromboembolic events in controlled trials of rFVIIa in spontaneous intracerebral hemorrhage. Stroke 39:850–856PubMedGoogle Scholar
  59. 59.
    Dirkmann D, Hanke AA, Gorlinger K, Peters J (2008) Hypothermia and acidosis synergistically impair coagulation in human whole blood. Anesth Analg 106:1627–1632PubMedGoogle Scholar
  60. 60.
    Donmez A, Turker H, Sekerci S, Kayhan Z, Ozbek N (1999) Dealing with a hemophilia-A patient undergoing cerebral aneurysm surgery. J Neurosurg Anesthesiol 11:214–215PubMedGoogle Scholar
  61. 61.
    Doughty HA, Coles J, Parmar K, Bullock P, Savidge GF (1995) The successful removal of a bleeding intracranial tumour in a severe haemophiliac using an adjusted dose continuous infusion of monoclonal factor VIII. Blood Coagul Fibrinolysis 6:31–34PubMedGoogle Scholar
  62. 62.
    Doughty HA, Northeast A, Sklair L, Roques T, Young AE, Savidge GF, Hunt BJ (1995) The use of recombinant factor VIIa in a patient with acquired haemophilia A undergoing surgery. Blood Coagul Fibrinolysis 6:125–128PubMedGoogle Scholar
  63. 63.
    Drews RE (2003) Critical issues in hematology: anemia, thrombocytopenia, coagulopathy, and blood product transfusions in critically ill patients. Clin Chest Med 24:607–622PubMedGoogle Scholar
  64. 64.
    Dunning J, Versteegh M, Fabbri A, Pavie A, Kolh P, Lockowandt U, Nashef SA (2008) Guideline on antiplatelet and anticoagulation management in cardiac surgery. Eur J Cardiothorac Surg 34:73–92PubMedGoogle Scholar
  65. 65.
    Durham SR, Liu KC, Selden NR (2006) Utility of serial computed tomography imaging in pediatric patients with head trauma. J Neurosurg 105:365–369PubMedGoogle Scholar
  66. 66.
    Dutton RP, McCunn M, Hyder M, D'Angelo M, O'Connor J, Hess JR, Scalea TM (2004) Factor VIIa for correction of traumatic coagulopathy. J Trauma 57:709–718PubMedGoogle Scholar
  67. 67.
    Dzik WH (2004) Predicting hemorrhage using preoperative coagulation screening assays. Curr Hematol Rep 3:324–330PubMedGoogle Scholar
  68. 68.
    Earnshaw SR, Joshi AV, Wilson MR, Rosand J (2006) Cost-effectiveness of recombinant activated factor VII in the treatment of intracerebral hemorrhage. Stroke 37:2751–2758PubMedGoogle Scholar
  69. 69.
    Edwards RL, Rickles FR (1992) The role of leukocytes in the activation of blood coagulation. Semin Hematol 29:202–212PubMedGoogle Scholar
  70. 70.
    Epstein NE (2005) A review of the risks and benefits of differing prophylaxis regimens for the treatment of deep venous thrombosis and pulmonary embolism in neurosurgery. Surg Neurol 64:295–301PubMedGoogle Scholar
  71. 71.
    Etemadrezaie H, Baharvahdat H, Shariati Z, Lari SM, Shakeri MT, Ganjeifar B (2007) The effect of fresh-frozen plasma in severe closed head injury. Clin Neurol Neurosurg 109:166–171PubMedGoogle Scholar
  72. 72.
    Evans G, Luddington R, Baglin T (2001) Beriplex P/N reverses severe warfarin-induced overanticoagulation immediately and completely in patients presenting with major bleeding. Br J Haematol 115:998–1001PubMedGoogle Scholar
  73. 73.
    Federici AB (2005) Management of von Willebrand disease with factor VIII/von Willebrand factor concentrates: results from current studies and surveys. Blood Coagul Fibrinolysis 16(Suppl 1):S17–S21PubMedGoogle Scholar
  74. 74.
    Fenger-Eriksen C, Ingerslev J, Tønnesen E, Sørensen B (2009) Citrate artificially masks the haemostatic effect of recombinant factor VIIa in dilutional coagulopathy. Ann Hematol 88(3):255–260Google Scholar
  75. 75.
    Fergusson DA, Hebert PC, Mazer CD, Fremes S, MacAdams C, Murkin JM, Teoh K, Duke PC, Arellano R, Blajchman MA, Bussieres JS, Cote D, Karski J, Martineau R, Robblee JA, Rodger M, Wells G, Clinch J, Pretorius R (2008) A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med 358:2319–2331PubMedGoogle Scholar
  76. 76.
    Fewel ME, Park P (2004) The emerging role of recombinant-activated factor VII in neurocritical care. Neurocrit Care 1:19–29PubMedGoogle Scholar
  77. 77.
    Flinn WR, Sandager GP, Silva MB Jr, Benjamin ME, Cerullo LJ, Taylor M (1996) Prospective surveillance for perioperative venous thrombosis. Experience in 2,643 patients. Arch Surg 131:472–480PubMedGoogle Scholar
  78. 78.
    Franchini M (2007) The use of desmopressin as a hemostatic agent: a concise review. Am J Hematol 82:731–735PubMedGoogle Scholar
  79. 79.
    Fredriksson K, Norrving B, Stromblad LG (1992) Emergency reversal of anticoagulation after intracerebral hemorrhage. Stroke 23:972–977PubMedGoogle Scholar
  80. 80.
    Freeman WD, Brott TG, Barrett KM, Castillo PR, Deen HG Jr, Czervionke LF, Meschia JF (2004) Recombinant factor VIIa for rapid reversal of warfarin anticoagulation in acute intracranial hemorrhage. Mayo Clin Proc 79:1495–1500PubMedGoogle Scholar
  81. 81.
    Fries D, Haas T, Klingler A, Streif W, Klima G, Martini J, Wagner-Berger H, Innerhofer P (2006) Efficacy of fibrinogen and prothrombin complex concentrate used to reverse dilutional coagulopathy–a porcine model. Br J Anaesth 97:460–467PubMedGoogle Scholar
  82. 82.
    Fries D, Streif W, Haas T, Kuhbacher G (2004) Dilutional coagulopathy, an underestimated problem? Anasthesiol Intensivmed Notfallmed Schmerzther 39:745–750PubMedGoogle Scholar
  83. 83.
    Frim DM, Barker FG, Poletti CE, Hamilton AJ (1992) Postoperative low-dose heparin decreases thromboembolic complications in neurosurgical patients. Neurosurgery 30:830–832PubMedGoogle Scholar
  84. 84.
    Fugh-Berman A (2000) Herb-drug interactions. Lancet 355:134–138PubMedGoogle Scholar
  85. 85.
    Fujii Y, Tanaka R, Takeuchi S, Koike T, Minakawa T, Sasaki O (1994) Serial changes in hemostasis after intracranial surgery. Neurosurgery 35:26–33PubMedGoogle Scholar
  86. 86.
    Fukamachi A, Koizumi H, Nukui H (1985) Postoperative intracerebral hemorrhages: a survey of computed tomographic findings after 1,074 intracranial operations. Surg Neurol 23:575–580PubMedGoogle Scholar
  87. 87.
    Gando S, Nakanishi Y, Tedo I (1995) Cytokines and plasminogen activator inhibitor-1 in posttrauma disseminated intravascular coagulation: relationship to multiple organ dysfunction syndrome. Crit Care Med 23:1835–1842PubMedGoogle Scholar
  88. 88.
    Geerts WH, Pineo GF, Heit JA, Bergqvist D, Lassen MR, Colwell CW, Ray JG (2004) Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126:338S–400SPubMedGoogle Scholar
  89. 89.
    Gelsomino S, Lorusso R, Romagnoli S, Bevilacqua S, De CG, Bille G, Stefano P, Gensini GF (2008) Treatment of refractory bleeding after cardiac operations with low-dose recombinant activated factor VII (NovoSeven): a propensity score analysis. Eur J Cardiothorac Surg 33:64–71PubMedGoogle Scholar
  90. 90.
    Gerlach R, Marquardt G, Wissing H, Scharrer I, Raabe A, Seifert V (2002) Application of recombinant activated factor VII during surgery for a giant skull base hemangiopericytoma to achieve safe hemostasis. Case report. J Neurosurg 96:946–948PubMedGoogle Scholar
  91. 91.
    Gerlach R, Raabe A, Beck J, Woszczyk A, Seifert V (2004) Postoperative nadroparin administration for prophylaxis of thromboembolic events is not associated with an increased risk of hemorrhage after spinal surgery. Eur Spine J 13(1):9–13Google Scholar
  92. 92.
    Gerlach R, Raabe A, Scharrer I, Meixensberger J, Seifert V (2004) Post-operative hematoma after surgery for intracranial meningiomas: causes, avoidable risk factors and clinical outcome. Neurol Res 26:61–66PubMedGoogle Scholar
  93. 93.
    Gerlach R, Raabe A, Zimmermann M, Siegemund A, Seifert V (2000) Factor XIII deficiency and postoperative hemorrhage after neurosurgical procedures [In Process Citation]. Surg Neurol 54:260–266PubMedGoogle Scholar
  94. 94.
    Gerlach R, Scheuer T, Beck J, Woszczyk A, Seifert V, Raabe A (2003) Risk of postoperative hemorrhage after intracranial surgery after early nadroparin administration: results of a prospective study. Neurosurgery 53:1028–1035PubMedGoogle Scholar
  95. 95.
    Gerlach R, Scheuer T, Bohm M, Beck J, Woszczyk A, Raabe A, Scharrer I, Seifert V (2003) Increased levels of plasma tissue factor pathway inhibitor in patients with glioblastoma and intracerebral metastases. Neurol Res 25:335–338PubMedGoogle Scholar
  96. 96.
    Gerlach R, Tolle F, Raabe A, Zimmermann M, Siegemund A, Seifert V (2002) Increased risk for postoperative hemorrhage after intracranial surgery in patients with decreased factor XIII activity: implications of a prospective study. Stroke 33:1618–1623PubMedGoogle Scholar
  97. 97.
    Gerstner T, Teich M, Bell N, Longin E, Dempfle CE, Brand J, Konig S (2006) Valproate-associated coagulopathies are frequent and variable in children. Epilepsia 47:1136–1143PubMedGoogle Scholar
  98. 98.
    Gnanalingham KK, Holland JP (2003) Attitudes to the use of prophylaxis for thrombo-embolism in neurosurgical patients. J Clin Neurosci 10:467–469PubMedGoogle Scholar
  99. 99.
    Goh KY, Poon WS, Chan DT, Ip CP (2005) Tissue plasminogen activator expression in meningiomas and glioblastomas. Clin Neurol Neurosurg 107:296–300PubMedGoogle Scholar
  100. 100.
    Goh KY, Tsoi WC, Feng CS, Wickham N, Poon WS (1997) Haemostatic changes during surgery for primary brain tumours. J Neurol Neurosurg Psychiatry 63:334–338PubMedGoogle Scholar
  101. 101.
    Goldhaber SZ, Dunn K, Gerhard-Herman M, Park JK, Black PM (2002) Low rate of venous thromboembolism after craniotomy for brain tumor using multimodality prophylaxis. Chest 122:1933–1937PubMedGoogle Scholar
  102. 102.
    Goldstein JN, Rosand J, Schwamm LH (2008) Warfarin reversal in anticoagulant-associated intracerebral hemorrhage. Neurocrit Care 9(2):277–283Google Scholar
  103. 103.
    Goobie SM, Soriano SG, Zurakowski D, McGowan FX, Rockoff MA (2001) Hemostatic changes in pediatric neurosurgical patients as evaluated by thrombelastograph. Anesth Analg 93:887–892PubMedGoogle Scholar
  104. 104.
    Goodnight SH, Kenoyer G, Rapaport SI, Patch MJ, Lee JA, Kurze T (1974) Defibrination after brain-tissue destruction: a serious complication of head injury. N Engl J Med 290:1043–1047PubMedGoogle Scholar
  105. 105.
    Goodnough LT (2004) Experiences with recombinant human factor VIIa in patients with thrombocytopenia. Semin Hematol 41:25–29PubMedGoogle Scholar
  106. 106.
    Gorlinger K (2006) Coagulation management during liver transplantation. Hamostaseologie 26:S64–S76PubMedGoogle Scholar
  107. 107.
    Gosseye S, van OL, Weynand B, Scheiff JM, Moulin D, de GJ de Ville, Otte JB (1991) Platelet aggregates in small lung vessels and death during liver transplantation. Lancet 338:532–534PubMedGoogle Scholar
  108. 108.
    Grady RE, Oliver WC Jr, Abel MD, Meyer FB (2002) Aprotinin and deep hypothermic cardiopulmonary bypass with or without circulatory arrest for craniotomy. J Neurosurg Anesthesiol 14:137–140PubMedGoogle Scholar
  109. 109.
    Grady RE, Oliver WC Jr, Abel MD, Meyer FB (2002) Aprotinin and deep hypothermic cardiopulmonary bypass with or without circulatory arrest for craniotomy. J Neurosurg Anesthesiol 14:137–140PubMedGoogle Scholar
  110. 110.
    Graham DI, Adams JH (1971) Ischaemic brain damage in fatal head injuries. Lancet 1:265–266PubMedGoogle Scholar
  111. 111.
    Graham DI, Ford I, Adams JH, Doyle D, Teasdale GM, Lawrence AE, McLellan DR (1989) Ischaemic brain damage is still common in fatal non-missile head injury. J Neurol Neurosurg Psychiatry 52:346–350PubMedGoogle Scholar
  112. 112.
    Greenberg MS (1997) Hematology. In: Greenberg MS (ed) Handbook of neurosurgery, 4th edn. Greenberg Graphics Inc., Lakeland, Florida, pp 491–523Google Scholar
  113. 113.
    Grenander A, Bredbacka S, Rydvall A, Aroch R, Edner G, Koskinen LO, Olivecrona M (2001) Antithrombin treatment in patients with traumatic brain injury: a pilot study. J Neurosurg Anesthesiol 13:49–56PubMedGoogle Scholar
  114. 114.
    Grounds M (2003) Recombinant factor VIIa (rFVIIa) and its use in severe bleeding in surgery and trauma: a review. Blood Rev 17(Suppl 1):S11–S21PubMedGoogle Scholar
  115. 115.
    Guan M, Su B, Lu Y (2002) Quantitative reverse transcription-PCR measurement of tissue factor mRNA in glioma. Mol Biotechnol 20:123–129PubMedGoogle Scholar
  116. 116.
    Hamilton MG, Hull RD, Pineo GF (1994) Venous thromboembolism in neurosurgery and neurology patients: a review. Neurosurgery 34:280–96, discussion 296PubMedGoogle Scholar
  117. 117.
    Hanley JP (2004) Warfarin reversal. J Clin Pathol 57:1132–1139PubMedGoogle Scholar
  118. 118.
    Hansen MK, Jensen MK, Andersen C (2006) Uncontrollable bleeding in a patient with head trauma treated with blood component therapy guided by thromboelastography. Ugeskr Laeger 168:3535–3536PubMedGoogle Scholar
  119. 119.
    Hardy JF, de Moerloose P, Samama M (2004) Massive transfusion and coagulopathy: pathophysiology and implications for clinical management. Can J Anaesth 51:293–310PubMedGoogle Scholar
  120. 120.
    Harrison TD, Laskosky J, Jazaeri O, Pasquale MD, Cipolle M (2005) “Low-dose” recombinant activated factor VII results in less blood and blood product use in traumatic hemorrhage. J Trauma 59:150–154PubMedGoogle Scholar
  121. 121.
    Hartmann M, Sucker C, Messing M (2006) Recombinant activated factor VII in the treatment of near-fatal bleeding during pediatric brain tumor surgery. Report of two cases and review of the literature. J Neurosurg 104:55–58PubMedGoogle Scholar
  122. 122.
    Hawryluk GW, Cusimano MD (2006) The role of recombinant activated factor VII in neurosurgery: hope or hype? J Neurosurg 105:859–868PubMedGoogle Scholar
  123. 123.
    Hendriks HG, Meijer K, de Wolf JT, Klompmaker IJ, Porte RJ, de Kam PJ, Hagenaars AJ, Melsen T, Slooff MJ, der MJ van (2001) Reduced transfusion requirements by recombinant factor VIIa in orthotopic liver transplantation: a pilot study. Transplantation 71:402–405PubMedGoogle Scholar
  124. 124.
    Hendriks HG, Meijer K, de Wolf JT, Porte RJ, Klompmaker IJ, Lip H, Slooff MJ, van der MJ (2002) Effects of recombinant activated factor VII on coagulation measured by thromboelastography in liver transplantation. Blood Coagul Fibrinolysis 13:309–313PubMedGoogle Scholar
  125. 125.
    Hiippala ST (1995) Dextran and hydroxyethyl starch interfere with fibrinogen assays. Blood Coagul Fibrinolysis 6:743–746PubMedGoogle Scholar
  126. 126.
    Hiippala ST, Myllyla GJ, Vahtera EM (1995) Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesth Analg 81:360–365PubMedGoogle Scholar
  127. 127.
    Ho AM, Dion PW, Cheng CA, Karmakar MK, Cheng G, Peng Z, Ng YW (2005) A mathematical model for fresh-frozen plasma transfusion strategies during major trauma resuscitation with ongoing hemorrhage. Can J Surg 48:470–478PubMedGoogle Scholar
  128. 128.
    Ho AM, Karmakar MK, Dion PW (2005) Are we giving enough coagulation factors during major trauma resuscitation? Am J Surg 190:479–484PubMedGoogle Scholar
  129. 129.
    Hoffman M, Monroe DM (2007) Coagulation 2006: a modern view of hemostasis. Hematol Oncol Clin North Am 21:1–11PubMedGoogle Scholar
  130. 130.
    Holland LL, Brooks JP (2006) Toward rational fresh-frozen plasma transfusion: the effect of plasma transfusion on coagulation test results. Am J Clin Pathol 126:133–139PubMedGoogle Scholar
  131. 131.
    Holland LL, Foster TM, Marlar RA, Brooks JP (2005) Fresh-frozen plasma is ineffective for correcting minimally elevated international normalized ratios. Transfusion 45:1234–1235PubMedGoogle Scholar
  132. 132.
    Holmin S, Soderlund J, Biberfeld P, Mathiesen T (1998) Intracerebral inflammation after human brain contusion. Neurosurgery 42:291–298PubMedGoogle Scholar
  133. 133.
    Hoots WK (1997) Experience with antithrombin concentrates in neurotrauma patients. Semin Thromb Hemost 23(Suppl 1):3–16PubMedGoogle Scholar
  134. 134.
    Hoots WK (1997) Experience with antithrombin concentrates in neurotrauma patients. Semin Thromb Hemost 23(Suppl 1):3–16PubMedGoogle Scholar
  135. 135.
    Hu Z, Yang X, Ho PC, Chan SY, Heng PW, Chan E, Duan W, Koh HL, Zhou S (2005) Herb-drug interactions: a literature review. Drugs 65:1239–1282PubMedGoogle Scholar
  136. 136.
    Huber A, Dorn A, Witzmann A, Cervos-Navarro J (1993) Microthrombi formation after severe head trauma. Int J Legal Med 106:152–155PubMedGoogle Scholar
  137. 137.
    Hulka F, Mullins RJ, Frank EH (1996) Blunt brain injury activates the coagulation process. Arch Surg 131:923–927PubMedGoogle Scholar
  138. 138.
    Innerhofer P, Fries D, Margreiter J, Klingler A, Kuhbacher G, Wachter B, Oswald E, Salner E, Frischhut B, Schobersberger W (2002) The effects of perioperatively administered colloids and crystalloids on primary platelet-mediated hemostasis and clot formation. Anesth Analg 95:858–65PubMedGoogle Scholar
  139. 139.
    Iorio A, Agnelli G (2000) Low-molecular-weight and unfractionated heparin for prevention of venous thromboembolism in neurosurgery: a meta-analysis. Arch Intern Med 160:2327–2332PubMedGoogle Scholar
  140. 140.
    Izzo AA, Ernst E (2001) Interactions between herbal medicines and prescribed drugs: a systematic review. Drugs 61:2163–2175PubMedGoogle Scholar
  141. 141.
    Jackson WL Jr, Shorr AF (2005) Blood transfusion and the development of acute respiratory distress syndrome: more evidence that blood transfusion in the intensive care unit may not be benign. Crit Care Med 33:1420–1421PubMedGoogle Scholar
  142. 142.
    James DN, Fernandes JR, Calder I, Smith M (1997) Low-dose aspirin and intracranial surgery. A survey of the opinions of consultant neuroanaesthetists in the UK. Anaesthesia 52:169–172PubMedGoogle Scholar
  143. 143.
    Jamnicki M, Bombeli T, Seifert B, Zollinger A, Camenzind V, Pasch T, Spahn DR (2000) Low- and medium-molecular-weight hydroxyethyl starches: comparison of their effect on blood coagulation. Anesthesiology 93:1231–1237PubMedGoogle Scholar
  144. 144.
    Jellinek DA, Robin F (2000) Perioperative Care. In: Kaye Andrew H et al (eds) Operative neurosurgery. Churchill Livingston, London, pp 15–32Google Scholar
  145. 145.
    Jones SB, Whitten CW, Despotis GJ, Monk TG (2003) The influence of crystalloid and colloid replacement solutions in acute normovolemic hemodilution: a preliminary survey of hemostatic markers. Anesth Analg 96:363–8PubMedGoogle Scholar
  146. 146.
    Kalabalikis P, Papazoglou K, Gouriotis D, Papadopoulos N, Kardara M, Papageorgiou F, Papadatos J (1999) Correlation between serum IL-6 and CRP levels and severity of head injury in children. Intensive Care Med 25:288–292PubMedGoogle Scholar
  147. 147.
    Kalfas IH, Little JR (1988) Postoperative hemorrhage: a survey of 4,992 intracranial procedures. Neurosurgery 23:343–347PubMedCrossRefGoogle Scholar
  148. 148.
    Kapiotis S, Quehenberger P, Eichler HG, Schwarzinger I, Partan C, Schneider B, Lechner K, Speiser W (1994) Effect of hydroxyethyl starch on the activity of blood coagulation and fibrinolysis in healthy volunteers: comparison with albumin. Crit Care Med 22:606–612PubMedGoogle Scholar
  149. 149.
    Karadimov D, Binev K, Nachkov Y, Platikanov V (2003) Use of activated recombinant factor VII (NovoSeven) during neurosurgery. J Neurosurg Anesthesiol 15:330–332PubMedGoogle Scholar
  150. 150.
    Kaufman HH, Hui KS, Mattson JC, Borit A, Childs TL, Hoots WK, Bernstein DP, Makela ME, Wagner KA, Kahan BD (1984) Clinicopathological correlations of disseminated intravascular coagulation in patients with head injury. Neurosurgery 15:34–42PubMedCrossRefGoogle Scholar
  151. 151.
    Kaufman HH, Moake JL, Olson JD, Miner ME, duCret RP, Pruessner JL, Gildenberg PL (1980) Delayed and recurrent intracranial hematomas related to disseminated intravascular clotting and fibrinolysis in head injury. Neurosurgery 7:445–449PubMedCrossRefGoogle Scholar
  152. 152.
    Kaufmann JE, Vischer UM (2003) Cellular mechanisms of the hemostatic effects of desmopressin (DDAVP). J Thromb Haemost 1:682–689PubMedGoogle Scholar
  153. 153.
    Kaushal R, Bates DW, Franz C, Soukup JR, Rothschild JM (2007) Costs of adverse events in intensive care units. Crit Care Med 35:2479–2483PubMedGoogle Scholar
  154. 154.
    Kaw LL Jr, Coimbra R, Potenza BM, Garfin SR, Hoyt DB (2004) The use of recombinant factor VIIa for severe intractable bleeding during spine surgery. Spine 29:1384–1387PubMedGoogle Scholar
  155. 155.
    Kearney TJ, Bentt L, Grode M, Lee S, Hiatt JR, Shabot MM (1992) Coagulopathy and catecholamines in severe head injury. J Trauma 32:608–611PubMedGoogle Scholar
  156. 156.
    Keimowitz RM, Annis BL (1973) Disseminated intravascular coagulation associated with massive brain injury. J Neurosurg 39:178–180PubMedGoogle Scholar
  157. 157.
    Kenet G, Walden R, Eldad A, Martinowitz U (1999) Treatment of traumatic bleeding with recombinant factor VIIa. Lancet 354:1879PubMedGoogle Scholar
  158. 158.
    Khan H, Belsher J, Yilmaz M, Afessa B, Winters JL, Moore SB, Hubmayr RD, Gajic O (2007) Fresh-frozen plasma and platelet transfusions are associated with development of acute lung injury in critically ill medical patients. Chest 131:1308–1314PubMedGoogle Scholar
  159. 159.
    Kis B, Szupera Z, Mezei Z, Gecse A, Telegdy G, Vecsei L (1999) Valproate treatment and platelet function: the role of arachidonate metabolites. Epilepsia 40:307–310PubMedGoogle Scholar
  160. 160.
    Kissela BM, Eckman MH (2008) Cost-effectiveness of recombinant factor VIIa for treatment of intracerebral hemorrhage. BMC Neurol 8:17PubMedGoogle Scholar
  161. 161.
    Kleindienst A, Harvey HB, Mater E, Bronst J, Flack J, Herenz K, Haupt WF, Schon R (2003) Early antithrombotic prophylaxis with low-molecular-weight heparin in neurosurgery. Acta Neurochir (Wien) 145:1085–1090Google Scholar
  162. 162.
    Knudson MM, Morabito D, Paiement GD, Shackleford S (1996) Use of low-molecular-weight heparin in preventing thromboembolism in trauma patients. J Trauma 41:446–459PubMedGoogle Scholar
  163. 163.
    Koizume S, Jin MS, Miyagi E, Hirahara F, Nakamura Y, Piao JH, Asai A, Yoshida A, Tsuchiya E, Ruf W, Miyagi Y (2006) Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII. Cancer Res 66:9453–9460PubMedGoogle Scholar
  164. 164.
    Konig SA, Schick U, Dohnert J, Goldammer A, Vitzthum HE (2003) Coagulopathy and outcome in patients with chronic subdural haematoma. Acta Neurol Scand 107:110–116PubMedGoogle Scholar
  165. 165.
    Koos W, Kraus H, Blumel G, Bock F (1970) Mode of action of proteinase inhibitors (Trasylol) in intracranial hemorrhages. Neurochirurgie 16:548–550PubMedGoogle Scholar
  166. 166.
    Korinth MC (2006) Low-dose aspirin before intracranial surgery—results of a survey among neurosurgeons in Germany. Acta Neurochir (Wien ) 148:1189–1196Google Scholar
  167. 167.
    Korinth MC, Gilsbach JM, Weinzierl MR. (2007) Low-dose aspirin before spinal surgery: results of a survey among neurosurgeons in Germany. Eur Spine J 16(3):365–372Google Scholar
  168. 168.
    Korte W (2006) Fibrin monomer and factor XIII: a new concept for unexplained intraoperative coagulopathy. Hamostaseologie 26:S30–S35PubMedGoogle Scholar
  169. 169.
    Koscielny J, Ziemer S, Radtke H, Schmutzler M, Pruss A, Sinha P, Salama A, Kiesewetter H, Latza R (2004) A practical concept for preoperative identification of patients with impaired primary hemostasis. Clin Appl Thromb Hemost 10:195–204PubMedGoogle Scholar
  170. 170.
    Kou J, Fischgrund J, Biddinger A, Herkowitz H (2002) Risk factors for spinal epidural hematoma after spinal surgery. Spine 27:1670–1673PubMedGoogle Scholar
  171. 171.
    Kozek-Langenecker SA (2005) Effects of hydroxyethyl starch solutions on hemostasis. Anesthesiology 103:654–660PubMedGoogle Scholar
  172. 172.
    Kreuz W, Linde R, Funk M, Meyer-Schrod R, Foll E, Nowak-Gottl U, Jacobi G, Vigh Z, Scharrer I (1992) Valproate therapy induces von Willebrand disease type I. Epilepsia 33:178–184PubMedGoogle Scholar
  173. 173.
    Kurtoglu M, Yanar H, Bilsel Y, Guloglu R, Kizilirmak S, Buyukkurt D, Granit V (2004) Venous thromboembolism prophylaxis after head and spinal trauma: intermittent pneumatic compression devices versus low-molecular-weight heparin. World J Surg 28:807–811PubMedGoogle Scholar
  174. 174.
    Kushimoto S, Shibata Y, Yamamoto Y (2003) Implications of fibrinogenolysis in patients with closed head injury. J Neurotrauma 20:357–363PubMedGoogle Scholar
  175. 175.
    Kushimoto S, Yamamoto Y, Shibata Y, Sato H, Koido Y (2001) Implications of excessive fibrinolysis and alpha(2)-plasmin inhibitor deficiency in patients with severe head injury. Neurosurgery 49:1084–1089PubMedGoogle Scholar
  176. 176.
    Kushimoto S, Yamamoto Y, Shibata Y, Sato H, Koido Y (2001) Implications of excessive fibrinolysis and alpha(2)-plasmin inhibitor deficiency in patients with severe head injury. Neurosurgery 49:1084–1089PubMedGoogle Scholar
  177. 177.
    Lackmann GM (2004) Valproic-acid-induced thrombocytopenia and hepatotoxicity: discontinuation of treatment? Pharmacology 70:57–58PubMedGoogle Scholar
  178. 178.
    Lang T, von DM (2006) Possibilities and limitations of thrombelastometry/-graphy. Hamostaseologie 26:S20–S29PubMedGoogle Scholar
  179. 179.
    Lankiewicz MW, Hays J, Friedman KD, Tinkoff G, Blatt PM (2006) Urgent reversal of warfarin with prothrombin complex concentrate. J Thromb Haemost 4:967–970PubMedGoogle Scholar
  180. 180.
    Lawton MT, Raudzens PA, Zabramski JM, Spetzler RF (1998) Hypothermic circulatory arrest in neurovascular surgery: evolving indications and predictors of patient outcome. Neurosurgery 43:10–20PubMedGoogle Scholar
  181. 181.
    Leithauser B, Zielske D, Seyfert UT, Jung F (2008) Effects of desmopressin on platelet membrane glycoproteins and platelet aggregation in volunteers on clopidogrel. Clin Hemorheol Microcirc 39:293–302PubMedGoogle Scholar
  182. 182.
    Levy JH (2006) Massive transfusion coagulopathy. Semin Hematol 43:S59–S63PubMedGoogle Scholar
  183. 183.
    Levy JH, Fingerhut A, Brott T, Langbakke IH, Erhardtsen E, Porte RJ (2006) Recombinant factor VIIa in patients with coagulopathy secondary to anticoagulant therapy, cirrhosis, or severe traumatic injury: review of safety profile. Transfusion 46:919–933PubMedGoogle Scholar
  184. 184.
    Lier H, Kampe S, Schroder S (2007) Prerequisites of a functional haemostasis. What must be considered at the scene of an accident, in the emergency room and during an operation? Anaesthesist 56:239–251PubMedGoogle Scholar
  185. 185.
    Lillicrap D, Nair SC, Srivastava A, Rodeghiero F, Pabinger I, Federici AB (2006) Laboratory issues in bleeding disorders. Haemophilia 12(Suppl 3):68–75PubMedGoogle Scholar
  186. 186.
    Lin J, Hanigan WC, Tarantino M, Wang J (2003) The use of recombinant activated factor VII to reverse warfarin-induced anticoagulation in patients with hemorrhages in the central nervous system: preliminary findings. J Neurosurg 98:737–740PubMedGoogle Scholar
  187. 187.
    Lisman T, Leebeek FW, Meijer K, van der MJ, Nieuwenhuis HK, de Groot PG (2002) Recombinant factor VIIa improves clot formation but not fibrolytic potential in patients with cirrhosis and during liver transplantation. Hepatology 35:616–621PubMedGoogle Scholar
  188. 188.
    Lodge JP, Jonas S, Jones RM, Olausson M, Mir-Pallardo J, Soefelt S, Garcia-Valdecasas JC, McAlister V, Mirza DF (2005) Efficacy and safety of repeated perioperative doses of recombinant factor VIIa in liver transplantation. Liver Transpl 11:973–979PubMedGoogle Scholar
  189. 189.
    Lorenz R, Kienast J, Otto U, Egger K, Kiehl M, Schreiter D, Kwasny H, Haertel S, Barthels M (2003) Efficacy and safety of a prothrombin complex concentrate with two virus-inactivation steps in patients with severe liver damage. Eur J Gastroenterol Hepatol 15:15–20PubMedGoogle Scholar
  190. 190.
    Lorenz R, Kienast J, Otto U, Kiehl M, Schreiter D, Haertel S, Barthels M (2007) Successful emergency reversal of phenprocoumon anticoagulation with prothrombin complex concentrate: a prospective clinical study. Blood Coagul Fibrinolysis 18:565–570PubMedGoogle Scholar
  191. 191.
    Lubetsky A, Hoffman R, Zimlichman R, Eldor A, Zvi J, Kostenko V, Brenner B (2004) Efficacy and safety of a prothrombin complex concentrate (Octaplex) for rapid reversal of oral anticoagulation. Thromb Res 113:371–378PubMedGoogle Scholar
  192. 192.
    Luxembourg B, Krause M, Lindhoff-Last E (2007) Blood clotting disorders. Deutsches Ärzteblatt 104:1489–1498Google Scholar
  193. 193.
    Lyseng-Williamson KA, Plosker GL (2007) Recombinant factor VIIa (eptacog alfa): a pharmacoeconomic review of its use in haemophilia in patients with inhibitors to clotting factors VIII or IX. Pharmacoeconomics 25:1007–1029PubMedGoogle Scholar
  194. 194.
    Macdonald RL, Amidei C, Baron J, Weir B, Brown F, Erickson RK, Hekmatpanah J, Frim D (2003) Randomized, pilot study of intermittent pneumatic compression devices plus dalteparin versus intermittent pneumatic compression devices plus heparin for prevention of venous thromboembolism in patients undergoing craniotomy. Surg Neurol 59:363–372PubMedGoogle Scholar
  195. 195.
    Macdonald RL, Amidei C, Lin G, Munshi I, Baron J, Weir BK, Brown F, Erickson RK, Hekmatpanah J (1999) Safety of perioperative subcutaneous heparin for prophylaxis of venous thromboembolism in patients undergoing craniotomy. Neurosurgery 45:245–251PubMedGoogle Scholar
  196. 196.
    Macik BG, Lindley CM, Lusher J, Sawyer WT, Bloom AL, Harrison JF, Baird-Cox K, Birch K, Glazer S, Roberts HR (1993) Safety and initial clinical efficacy of three dose levels of recombinant activated factor VII (rFVIIa): results of a phase I study. Blood Coagul Fibrinolysis 4:521–527PubMedGoogle Scholar
  197. 197.
    MacLennan S, Williamson LM (2006) Risks of fresh-frozen plasma and platelets. J Trauma 60:S46–S50PubMedGoogle Scholar
  198. 198.
    Makris M, Greaves M, Phillips WS, Kitchen S, Rosendaal FR, Preston EF (1997) Emergency oral anticoagulant reversal: the relative efficacy of infusions of fresh-frozen plasma and clotting factor concentrate on correction of the coagulopathy. Thromb Haemost 77:477–480PubMedGoogle Scholar
  199. 199.
    Malham GM, Souter MJ (2001) Systemic inflammatory response syndrome and acute neurological disease. Br J Neurosurg 15:381–387PubMedGoogle Scholar
  200. 200.
    Mangano DT, Rieves RD, Weiss KD (2006) Judging the safety of aprotinin. N Engl J Med 355:2261–2262PubMedGoogle Scholar
  201. 201.
    Mangano DT, Tudor IC, Dietzel C (2006) The risk associated with aprotinin in cardiac surgery. N Engl J Med 354:353–365PubMedGoogle Scholar
  202. 202.
    Martini WZ, Pusateri AE, Uscilowicz JM, Delgado AV, Holcomb JB (2005) Independent contributions of hypothermia and acidosis to coagulopathy in swine. J Trauma 58:1002–1009PubMedGoogle Scholar
  203. 203.
    Martinowitz U, Michaelson M (2005) Guidelines for the use of recombinant activated factor VII (rFVIIa) in uncontrolled bleeding: a report by the Israeli Multidisciplinary rFVIIa Task Force. J Thromb Haemost 3:640–648PubMedGoogle Scholar
  204. 204.
    May AK, Young JS, Butler K, Bassam D, Brady W (1997) Coagulopathy in severe closed head injury: is empiric therapy warranted? Am Surg 63:233–236PubMedGoogle Scholar
  205. 205.
    Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T (2005) Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med 352:777–785PubMedGoogle Scholar
  206. 206.
    Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T (2008) Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med 358:2127–2137PubMedGoogle Scholar
  207. 207.
    Mayer SA, Brun NC, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T (2005) Safety and feasibility of recombinant factor VIIa for acute intracerebral hemorrhage. Stroke 36:74–79PubMedGoogle Scholar
  208. 208.
    Mazer CD, Leong-Poi H, Mahoney J, Latter D, Strauss BH, Teitel JM (2007) Vascular injury and thrombotic potential: a note of caution about recombinant factor VIIa. Semin Cardiothorac Vasc Anesth 11:261–264PubMedGoogle Scholar
  209. 209.
    McLoughlin TM, Fontana JL, Alving B, Mongan PD, Bunger R (1996) Profound normovolemic hemodilution: hemostatic effects in patients and in a porcine model. Anesth Analg 83:459–465PubMedGoogle Scholar
  210. 210.
    Merriman E, Bell W, Long DM (1979) Surgical postoperative bleeding associated with aspirin ingestion. Report of two cases. J Neurosurg 50:682–684PubMedGoogle Scholar
  211. 211.
    Mittermayr M, Streif W, Haas T, Fries D, Velik-Salchner C, Klingler A, Oswald E, Bach C, Schnapka-Koepf M, Innerhofer P (2007) Hemostatic changes after crystalloid or colloid fluid administration during major orthopedic surgery: the role of fibrinogen administration. Anesth Analg 105:905–17PubMedGoogle Scholar
  212. 212.
    Monroe DM, Hoffman M, Roberts HR (2002) Platelets and thrombin generation. Arterioscler Thromb Vasc Biol 22:1381–1389PubMedGoogle Scholar
  213. 213.
    Morenski JD, Tobias JD, Jimenez DF (2003) Recombinant activated factor VII for cerebral injury-induced coagulopathy in pediatric patients. Report of three cases and review of the literature. J Neurosurg 98:611–616PubMedGoogle Scholar
  214. 214.
    Munro J, Booth A, Nicholl J (1997) Routine preoperative testing: a systematic review of the evidence. Health Technol Assess 1:i–ivPubMedGoogle Scholar
  215. 215.
    Nakau H, Maruishi M, Takiguchi H, Shima K (1998) Successful surgical removal of a large arteriovenous malformation in a patient with hemophilia: case report. Neurosurgery 43:1459–1461PubMedGoogle Scholar
  216. 216.
    Neilipovitz DT (2004) Tranexamic acid for major spinal surgery. Eur Spine J 13(Suppl 1):S62–S65PubMedGoogle Scholar
  217. 217.
    Nekludov M, Bellander BM, Blomback M, Wallen HN (2007) Platelet dysfunction in patients with severe traumatic brain injury. J Neurotrauma 24:1699–1706PubMedGoogle Scholar
  218. 218.
    Niemi T, Tanskanen P, Taxell C, Juvela S, Randell T, Rosenberg P (1999) Effects of nonsteroidal anti-inflammatory drugs on hemostasis in patients with aneurysmal subarachnoid hemorrhage. J Neurosurg Anesthesiol 11:188–194PubMedGoogle Scholar
  219. 219.
    Ninchoji T, Uemura K, Shimoyama I, Hinokuma K, Bun T, Nakajima S (1984) Traumatic intracerebral haematomas of delayed onset. Acta Neurochir (Wien) 71:69–90Google Scholar
  220. 220.
    Nurmohamed MT, van Riel AM, Henkens CM, Koopman MM, Que GT, d’Azemar P, Buller HR, ten Cate JW, Hoek JA, van der MJ, van der HC, Turpie AG, Haley S, Sicurella A, Gent M (1996) low-molecular-weight heparin and compression stockings in the prevention of venous thromboembolism in neurosurgery. Thromb Haemost 75:233–238PubMedGoogle Scholar
  221. 221.
    O’Connell KA, Wood JJ, Wise RP, Lozier JN, Braun MM (2006) Thromboembolic adverse events after use of recombinant human coagulation factor VIIa. JAMA 295:293–298PubMedGoogle Scholar
  222. 222.
    Oertel M, Kelly DF, McArthur D, Boscardin WJ, Glenn TC, Lee JH, Gravori T, Obukhov D, McBride DQ, Martin NA (2002) Progressive hemorrhage after head trauma: predictors and consequences of the evolving injury. J Neurosurg 96:109–116PubMedGoogle Scholar
  223. 223.
    Olson JD, Kaufman HH, Moake J, O’Gorman TW, Hoots K, Wagner K, Brown CK, Gildenberg PL (1989) The incidence and significance of hemostatic abnormalities in patients with head injuries. Neurosurgery 24:825–832PubMedGoogle Scholar
  224. 224.
    Ostermann H, Haertel S, Knaub S, Kalina U, Jung K, Pabinger I (2007) Pharmacokinetics of Beriplex P/N prothrombin complex concentrate in healthy volunteers. Thromb Haemost 98:790–797PubMedGoogle Scholar
  225. 225.
    Pabinger I, Brenner B, Kalina U, Knaub S, Nagy A, Ostermann H (2008) Prothrombin complex concentrate (Beriplex P/N) for emergency anticoagulation reversal: a prospective multinational clinical trial. J Thromb Haemost 6:622–631PubMedGoogle Scholar
  226. 226.
    Palmer JD, Francis DA, Roath OS, Francis JL, Iannotti F (1995) Hyperfibrinolysis during intracranial surgery: effect of high dose aprotinin. J Neurol Neurosurg Psychiatry 58:104–106PubMedGoogle Scholar
  227. 227.
    Palmer JD, Francis JL, Pickard JD, Iannotti F (2003) The efficacy and safety of aprotinin for hemostasis during intracranial surgery. J Neurosurg 98:1208–1216PubMedGoogle Scholar
  228. 228.
    Palmer JD, Sparrow OC, Iannotti F (1994) Postoperative hematoma: a 5-year survey and identification of avoidable risk factors. Neurosurgery 35:1061–1064PubMedGoogle Scholar
  229. 229.
    Parameswaran R, Shapiro AD, Gill JC, Kessler CM (2005) Dose effect and efficacy of rFVIIa in the treatment of haemophilia patients with inhibitors: analysis from the Hemophilia and Thrombosis Research Society Registry. Haemophilia 11:100–106PubMedGoogle Scholar
  230. 230.
    Park P, Fewel ME, Garton HJ, Thompson BG, Hoff JT (2003) Recombinant activated factor VII for the rapid correction of coagulopathy in nonhemophilic neurosurgical patients. Neurosurgery 53:34–38PubMedGoogle Scholar
  231. 231.
    Pathak A, Dutta S, Marwaha N, Singh D, Varma N, Mathuriya SN (2005) Change in tissue thromboplastin content of brain following trauma. Neurol India 53:178–182PubMedCrossRefGoogle Scholar
  232. 232.
    Pernod G, Barro C, Arnutti B, Blanc-Jouvan F, Garrel S, Kahn P, Minotti L, Koudsie A, Benabid AL, Wrobleski I, Joannard A, Polack B (2003) Surgery in severe factor XIII deficiency: report of a case of epilepsy neurosurgery and review. Haemophilia 9:121–124PubMedGoogle Scholar
  233. 233.
    Pfanner G, Koscielny J, Pernerstorfer T, Gutl M, Perger P, Fries D, Hofmann N, Innerhofer P, Kneifl W, Neuner L, Schochl H, Kozek-Langenecker SA (2007) Preoperative evaluation of the bleeding history. Recommendations of the working group on perioperative coagulation of the Austrian Society for Anaesthesia, Resuscitation and Intensive Care. Anaesthesist 56:604–611PubMedGoogle Scholar
  234. 234.
    Pickard JD, Kirkpatrick PJ, Melsen T, Andreasen RB, Gelling L, Fryer T, Matthews J, Minhas P, Hutchinson PJ, Menon D, Downey SP, Kendall I, Clark J, Carpenter TA, Williams E, Persson L (2000) Potential role of NovoSeven in the prevention of rebleeding following aneurysmal subarachnoid haemorrhage. Blood Coagul Fibrinolysis 11(Suppl 1):S117–20 S117-S120PubMedGoogle Scholar
  235. 235.
    Piek J, Chesnut RM, Marshall LF, Berkum-Clark M, Klauber MR, Blunt BA, Eisenberg HM, Jane JA, Marmarou A, Foulkes MA (1992) Extracranial complications of severe head injury. J Neurosurg 77:901–907PubMedGoogle Scholar
  236. 236.
    Planinsic RM, van der MJ, Testa G, Grande L, Candela A, Porte RJ, Ghobrial RM, Isoniemi H, Schelde PB, Erhardtsen E, Klintmalm G, Emre S (2005) Safety and efficacy of a single bolus administration of recombinant factor VIIa in liver transplantation due to chronic liver disease. Liver Transpl 11:895–900PubMedGoogle Scholar
  237. 237.
    Pohlmann-Eden B, Peters CN, Wennberg R, Dempfle CE (2003) Valproate induces reversible factor XIII deficiency with risk of perioperative bleeding. Acta Neurol Scand 108:142–145PubMedGoogle Scholar
  238. 238.
    Pondaag W (1979) Disseminated intravascular coagulation related to outcome in head injury. Acta Neurochir Suppl (Wien) 28:98–102Google Scholar
  239. 239.
    Powner DJ, Hartwell EA, Hoots WK (2005) Counteracting the effects of anticoagulants and antiplatelet agents during neurosurgical emergencies. Neurosurgery 57:823–831PubMedGoogle Scholar
  240. 240.
    Prasad KS, Sharma BS, Marwaha N, Sarode RS, Kak VK (1994) Haemostatic derangement in patients with intracranial tumours. Br J Neurosurg 8:695–702PubMedGoogle Scholar
  241. 241.
    Preston FE, Laidlaw ST, Sampson B, Kitchen S (2002) Rapid reversal of oral anticoagulation with warfarin by a prothrombin complex concentrate (Beriplex): efficacy and safety in 42 patients. Br J Haematol 116:619–624PubMedGoogle Scholar
  242. 242.
    Raabe A, Beck J, Keller M, Vatter H, Zimmermann M, Seifert V (2005) Relative importance of hypertension compared with hypervolemia for increasing cerebral oxygenation in patients with cerebral vasospasm after subarachnoid hemorrhage. J Neurosurg 103:974–981PubMedGoogle Scholar
  243. 243.
    Raabe A, Gerlach R, Zimmermann M, Seifert V (2000) Practice of perioperative thromboembolic prophylaxis in neurosurgery: results of a German survey. Zentralbl Neurochir 61:103–110PubMedGoogle Scholar
  244. 244.
    Raabe A, Gerlach R, Zimmermann M, Seifert V (2001) The risk of haemorrhage associated with early postoperative heparin administration after intracranial surgery. Acta Neurochir (Wien) 143:1–7Google Scholar
  245. 245.
    Ranucci M, Isgro G, Soro G, Conti D, De TB (2008) Efficacy and safety of recombinant activated factor vii in major surgical procedures: systematic review and meta-analysis of randomized clinical trials. Arch Surg 143:296–304PubMedGoogle Scholar
  246. 246.
    Rao JS, Rayford A, Morantz RA, Festoff BW, Sawaya R (1993) Increased levels of plasminogen activator inhibitor-1 (PAI-1) in human brain tumors. J Neurooncol 17:215–221PubMedGoogle Scholar
  247. 247.
    Rebulla P (2001) Platelet transfusion trigger in difficult patients. Transfus Clin Biol 8:249–254PubMedGoogle Scholar
  248. 248.
    Reinhofer M, Brauer M, Franke U, Barz D, Marx G, Losche W (2008) The value of rotation thromboelastometry to monitor disturbed perioperative haemostasis and bleeding risk in patients with cardiopulmonary bypass. Blood Coagul Fibrinolysis 19:212–219PubMedGoogle Scholar
  249. 249.
    Resnick DK, Marion DW, Darby JM (1994) The effect of hypothermia on the incidence of delayed traumatic intracerebral hemorrhage. Neurosurgery 34:252–255PubMedGoogle Scholar
  250. 250.
    Reymond MA, Marbet G, Radu EW, Gratzl O (1992) Aspirin as a risk factor for hemorrhage in patients with head injuries. Neurosurg Rev 15:21–25PubMedGoogle Scholar
  251. 251.
    Richards PG, Marath A, Edwards JM, Lincoln C (1987) Management of difficult intracranial aneurysms by deep hypothermia and elective cardiac arrest using cardiopulmonary bypass. Br J Neurosurg 1:261–269PubMedGoogle Scholar
  252. 252.
    Riess HB, Meier-Hellmann A, Motsch J, Elias M, Kursten FW, Dempfle CE (2007) Prothrombin complex concentrate (Octaplex) in patients requiring immediate reversal of oral anticoagulation. Thromb Res 121:9–16PubMedGoogle Scholar
  253. 253.
    Rizoli SB (2003) Crystalloids and colloids in trauma resuscitation: a brief overview of the current debate. J Trauma 54:S82–S88PubMedGoogle Scholar
  254. 254.
    Rodas RA, Fenstermaker RA, McKeever PE, Blaivas M, Dickinson LD, Papadopoulos SM, Hoff JT, Hopkins LN, Duffy-Fronckowiak M, Greenberg HS (1998) Correlation of intraluminal thrombosis in brain tumor vessels with postoperative thrombotic complications: a preliminary report. J Neurosurg 89:200–205PubMedGoogle Scholar
  255. 255.
    Rodeghiero F, Castaman G (2005) Treatment of von Willebrand disease. Semin Hematol 42:29–35PubMedGoogle Scholar
  256. 256.
    Roitberg B, Emechebe-Kennedy O, Amin-Hanjani S, Mucksavage J, Tesoro E (2005) Human recombinant factor VII for emergency reversal of coagulopathy in neurosurgical patients: a retrospective comparative study. Neurosurgery 57:832–836PubMedGoogle Scholar
  257. 257.
    Rong Y, Durden DL, Van Meir EG, Brat DJ (2006) 'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis. J Neuropathol Exp Neurol 65:529–539PubMedGoogle Scholar
  258. 258.
    Rong Y, Hu F, Huang R, Mackman N, Horowitz JM, Jensen RL, Durden DL, Van Meir EG, Brat DJ (2006) Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanisms. Cancer Res 66:7067–7074PubMedGoogle Scholar
  259. 259.
    Saito N, Yamazaki M, Kobayashi S, Teramoto A (2006) Resection of arteriovenous malformation in a patient with hemophilia type A. Neurol Med Chir (Tokyo) 46:191–193Google Scholar
  260. 260.
    Samama CM (2004) Aprotinin and major orthopedic surgery. Eur Spine J 13(Suppl 1):S56–S61PubMedGoogle Scholar
  261. 261.
    Samama CM, Djoudi R, Lecompte T, Nathan-Denizot N, Schved JF (2005) Perioperative platelet transfusion: recommendations of the Agence Francaise de Securite Sanitaire des Produits de Sante (AFSSaPS) 2003. Can J Anaesth 52:30–37PubMedGoogle Scholar
  262. 262.
    Sawaya R, Cummins CJ, Kornblith PL (1984) Brain tumors and plasmin inhibitors. Neurosurgery 15:795–800PubMedCrossRefGoogle Scholar
  263. 263.
    Sawaya R, Ramo OJ, Glas-Greenwalt P, Wu SZ (1991) Plasma fibrinolytic profile in patients with brain tumors. Thromb Haemost 65:15–19PubMedGoogle Scholar
  264. 264.
    Sawaya R, Zuccarello M, Elkalliny M, Nishiyama H (1992) Postoperative venous thromboembolism and brain tumors: Part I. Clinical profile. J Neurooncol 14:119–125PubMedGoogle Scholar
  265. 265.
    Scharbert G, Gebhardt K, Sow Z, Duris M, Deusch E, Kozek-Langenecker S (2007) Point-of-care platelet function tests: detection of platelet inhibition induced by nonopioid analgesic drugs. Blood Coagul Fibrinolysis 18:775–780PubMedGoogle Scholar
  266. 266.
    Schuster R, Waxman K (2005) Is repeated head computed tomography necessary for traumatic intracranial hemorrhage? Am Surg 71:701–704PubMedGoogle Scholar
  267. 267.
    Sciacca FL, Ciusani E, Silvani A, Corsini E, Frigerio S, Pogliani S, Parati E, Croci D, Boiardi A, Salmaggi A (2004) Genetic and plasma markers of venous thromboembolism in patients with high grade glioma. Clin Cancer Res 10:1312–1317PubMedGoogle Scholar
  268. 268.
    Selladurai BM, Vickneswaran M, Duraisamy S, Atan M (1997) Coagulopathy in acute head injury–a study of its role as a prognostic indicator. Br J Neurosurg 11:398–404PubMedGoogle Scholar
  269. 269.
    Semrad TJ, O'Donnell R, Wun T, Chew H, Harvey D, Zhou H, White RH (2007) Epidemiology of venous thromboembolism in 9,489 patients with malignant glioma. J Neurosurg 106:601–608PubMedGoogle Scholar
  270. 270.
    Serdaroglu G, Tutuncuoglu S, Kavakli K, Tekgul H (2002) Coagulation abnormalities and acquired von Willebrand's disease type 1 in children receiving valproic acid. J Child Neurol 17:41–43PubMedGoogle Scholar
  271. 271.
    Seremetis S (2003) Dose optimization of recombinant factor VIIa in the treatment of acute bleeding in haemophilia-associated inhibitors. Blood Coagul Fibrinolysis 14(Suppl 1):S29–S30PubMedGoogle Scholar
  272. 272.
    Shander A (2007) Financial and clinical outcomes associated with surgical bleeding complications. Surgery 142:S20–S25PubMedGoogle Scholar
  273. 273.
    Shander A, Hofmann A, Gombotz H, Theusinger OM, Spahn DR (2007) Estimating the cost of blood: past, present, and future directions. Best Pract Res Clin Anaesthesiol 21:271–289PubMedGoogle Scholar
  274. 274.
    Shapiro AD, Gilchrist GS, Hoots WK, Cooper HA, Gastineau DA (1998) Prospective, randomised trial of two doses of rFVIIa (NovoSeven) in haemophilia patients with inhibitors undergoing surgery. Thromb Haemost 80:773–778PubMedGoogle Scholar
  275. 275.
    Shore-Lesserson L, Manspeizer HE, DePerio M, Francis S, Vela-Cantos F, Ergin MA (1999) Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesth Analg 88:312–319PubMedGoogle Scholar
  276. 276.
    Singbartl K, Innerhofer P, Radvan J, Westphalen B, Fries D, Stogbauer R, Van AH (2003) Hemostasis and hemodilution: a quantitative mathematical guide for clinical practice. Anesth Analg 96:929–35PubMedGoogle Scholar
  277. 277.
    Singh VP, Jain D, Mohan R, Bhatia R, Bhargava M (1990) Haemostatic abnormalities in brain tumours. Acta Neurochir (Wien) 102:103–107Google Scholar
  278. 278.
    Smith SF, Simpson JM, Sekhon LH (2004) Prophylaxis for deep venous thrombosis in neurosurgical oncology: review of 2779 admissions over a 9-year period. Neurosurg Focus 17:E4PubMedGoogle Scholar
  279. 279.
    Sorensen B, Ingerslev J (2004) Thromboelastography and recombinant factor VIIa-hemophilia and beyond. Semin Hematol 41:140–144PubMedGoogle Scholar
  280. 280.
    Sorensen B, Ingerslev J (2005) Tailoring haemostatic treatment to patient requirements—an update on monitoring haemostatic response using thrombelastography. Haemophilia 11(Suppl 1):1–6PubMedGoogle Scholar
  281. 281.
    Sorensen B, Ingerslev J (2006) A direct thrombin inhibitor studied by dynamic whole blood clot formation. Haemostatic response to ex-vivo addition of recombinant factor VIIa or activated prothrombin complex concentrate. Thromb Haemost 96:446–453PubMedGoogle Scholar
  282. 282.
    Sorensen B, Johansen P, Nielsen GL, Sorensen JC, Ingerslev J (2003) Reversal of the international normalized ratio with recombinant activated factor VII in central nervous system bleeding during warfarin thromboprophylaxis: clinical and biochemical aspects. Blood Coagul Fibrinolysis 14:469–477PubMedGoogle Scholar
  283. 283.
    Sorimachi T, Fujii Y, Morita K, Tanaka R (2005) Rapid administration of antifibrinolytics and strict blood pressure control for intracerebral hemorrhage. Neurosurgery 57:837–844PubMedGoogle Scholar
  284. 284.
    Spahn DR, Cerny V, Coats TJ, Duranteau J, Fernandez-Mondejar E, Gordini G, Stahel PF, Hunt BJ, Komadina R, Neugebauer E, Ozier Y, Riddez L, Schultz A, Vincent JL, Rossaint R (2007) Management of bleeding following major trauma: a European guideline. Crit Care 11:R17PubMedGoogle Scholar
  285. 285.
    Spahn DR, Rossaint R (2005) Coagulopathy and blood component transfusion in trauma. Br J Anaesth 95:130–139PubMedGoogle Scholar
  286. 286.
    Spalding GJ, Hartrumpf M, Sierig T, Oesberg N, Kirschke CG, Albes JM (2007) Cost reduction of perioperative coagulation management in cardiac surgery: value of “bedside” thrombelastography (ROTEM). Eur J Cardiothorac Surg 31:1052–1057PubMedGoogle Scholar
  287. 287.
    Spiess BD, Royston D, Levy JH, Fitch J, Dietrich W, Body S, Murkin J, Nadel A (2004) Platelet transfusions during coronary artery bypass graft surgery are associated with serious adverse outcomes. Transfusion 44:1143–1148PubMedGoogle Scholar
  288. 288.
    Squizzato A, Ageno W (2007) Recombinant activated factor VII as a general haemostatic agent: evidence-based efficacy and safety. Current Drug Safety 2:155–161PubMedGoogle Scholar
  289. 289.
    Stanworth SJ (2007) The evidence-based use of FFP and cryoprecipitate for abnormalities of coagulation tests and clinical coagulopathy. Hematology Am Soc Hematol Educ Program 2007:179–186Google Scholar
  290. 290.
    Stanworth SJ, Birchall J, Doree CJ, Hyde C (2007) Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia. Cochrane Database Syst Rev: CD005011Google Scholar
  291. 291.
    Stanworth SJ, Brunskill SJ, Hyde CJ, McClelland DB, Murphy MF (2004) Is fresh-frozen plasma clinically effective? A systematic review of randomized controlled trials. Br J Haematol 126:139–152PubMedGoogle Scholar
  292. 292.
    Steen CK, Astermark J, Donfield S, Berntorp E (2008) Cost and outcome: comparisons of two alternative bypassing agents for persons with haemophilia A complicated by an inhibitor. Thromb Haemost 99:1060–1067Google Scholar
  293. 293.
    Stein SC, Chen XH, Sinson GP, Smith DH (2002) Intravascular coagulation: a major secondary insult in nonfatal traumatic brain injury. J Neurosurg 97:1373–1377PubMedGoogle Scholar
  294. 294.
    Stein SC, Graham DI, Chen XH, Smith DH (2004) Association between intravascular microthrombosis and cerebral ischemia in traumatic brain injury. Neurosurgery 54:687–691PubMedGoogle Scholar
  295. 295.
    Stein SC, Smith DH (2004) Coagulopathy in traumatic brain injury. Neurocrit Care 1:479–488PubMedGoogle Scholar
  296. 296.
    Stein SC, Smith DH (2004) Coagulopathy in traumatic brain injury. Neurocrit Care 1:479–488PubMedGoogle Scholar
  297. 297.
    Stein SC, Spettell C, Young G, Ross SE (1993) Delayed and progressive brain injury in closed-head trauma: radiological demonstration. Neurosurgery 32:25–30PubMedGoogle Scholar
  298. 298.
    Stein SC, Spettell CM (1995) Delayed and progressive brain injury in children and adolescents with head trauma. Pediatr Neurosurg 23:299–304PubMedGoogle Scholar
  299. 299.
    Stein SC, Young GS, Talucci RC, Greenbaum BH, Ross SE (1992) Delayed brain injury after head trauma: significance of coagulopathy. Neurosurgery 30:160–165PubMedGoogle Scholar
  300. 300.
    Steiner ME, Despotis GJ (2007) Transfusion algorithms and how they apply to blood conservation: the high-risk cardiac surgical patient. Hematol Oncol Clin North Am 21:177–184PubMedGoogle Scholar
  301. 301.
    Stephens PH, Healy MT, Smith M, Jewkes DA (1995) Prophylaxis against thromboembolism in neurosurgical patients: a survey of current practice in the United Kingdom. Br J Neurosurg 9:159–163PubMedGoogle Scholar
  302. 302.
    Stratmann G, Russell IA, Merrick SH (2003) Use of recombinant factor VIIa as a rescue treatment for intractable bleeding following repeat aortic arch repair. Ann Thorac Surg 76:2094–2097PubMedGoogle Scholar
  303. 303.
    Sugg RM, Gonzales NR, Matherne DE, Ribo M, Shaltoni HM, Baraniuk S, Noser EA, Grotta JC (2006) Myocardial injury in patients with intracerebral hemorrhage treated with recombinant factor VIIa. Neurology 67:1053–1055PubMedGoogle Scholar
  304. 304.
    Taketomi T, Szlam F, Levy JH, Tanaka KA (2008) Warfarin reversal with prothrombin complex concentrate confers better antifibrinolytic activity compared with recombinant activated factor VII. Blood Coagul Fibrinolysis 19:106–108PubMedGoogle Scholar
  305. 305.
    Tanaka KA, Szlam F, Dickneite G, Levy JH (2008) Effects of prothrombin complex concentrate and recombinant activated factor VII on vitamin K antagonist induced anticoagulation. Thromb Res 122:117–123PubMedGoogle Scholar
  306. 306.
    Tanaka KA, Taketomi T, Szlam F, Calatzis A, Levy JH (2008) Improved clot formation by combined administration of activated factor VII (NovoSeven) and fibrinogen (Haemocomplettan P). Anesth Analg 106:732–8PubMedGoogle Scholar
  307. 307.
    Taylor WA, Thomas NW, Wellings JA, Bell BA (1995) Timing of postoperative intracranial hematoma development and implications for the best use of neurosurgical intensive care [see comments]. J Neurosurg 82:48–50PubMedGoogle Scholar
  308. 308.
    Teasdale GM, Pettigrew LE, Wilson JT, Murray G, Jennett B (1998) Analyzing outcome of treatment of severe head injury: a review and update on advancing the use of the Glasgow Outcome Scale. J Neurotrauma 15:587–597PubMedGoogle Scholar
  309. 309.
    Teich M, Longin E, Dempfle CE, Konig S (2004) Factor XIII deficiency associated with valproate treatment. Epilepsia 45:187–189PubMedGoogle Scholar
  310. 310.
    Thoron L, Arbit E (1994) Hemostatic changes in patients with brain tumors. J Neurooncol 22:87–100PubMedGoogle Scholar
  311. 311.
    Toth O, Calatzis A, Penz S, Losonczy H, Siess W (2006) Multiple electrode aggregometry: a new device to measure platelet aggregation in whole blood. Thromb Haemost 96:781–788PubMedGoogle Scholar
  312. 312.
    Treib J, Haass A, Pindur G (1997) Coagulation disorders caused by hydroxyethyl starch. Thromb Haemost 78:974–983PubMedGoogle Scholar
  313. 313.
    Treib J, Haass A, Pindur G, Grauer MT, Jung F, Wenzel E, Schimrigk K (1997) Increased haemorrhagic risk after repeated infusion of highly substituted medium molecular weight hydroxyethyl starch. Arzneimittelforschung 47:18–22PubMedGoogle Scholar
  314. 314.
    Treib J, Haass A, Pindur G, Grauer MT, Treib W, Wenzel E, Schimrigk K (1996) Influence of low and medium molecular weight hydroxyethyl starch on platelets during a long-term hemodilution in patients with cerebrovascular diseases. Arzneimittelforschung 46:1064–1066PubMedGoogle Scholar
  315. 315.
    Treib J, Haass A, Pindur G, Grauer MT, Wenzel E, Schimrigk K (1996) Decrease of fibronectin following repeated infusion of highly substituted hydroxyethyl starch. Infusionsther Transfusionsmed 23:71–75PubMedGoogle Scholar
  316. 316.
    Treib J, Haass A, Pindur G, Miyachita C, Grauer MT, Jung F, Wenzel E, Schimrigk K (1996) Highly substituted hydroxyethyl starch (HES200/0.62) leads to Type-I von Willebrand syndrome after repeated administration. Haemostasis 26:210–213PubMedGoogle Scholar
  317. 317.
    Treib J, Haass A, Pindur G, Treib W, Wenzel E, Schimrigk K (1996) Influence of intravascular molecular weight of hydroxyethyl starch on platelets. Eur J Haematol 56:168–172PubMedCrossRefGoogle Scholar
  318. 318.
    Trowbridge CC, Stammers AH, Ciccarelli N, Klayman M (2006) Dose titration of recombinant factor VIIa using thromboelastograph monitoring in a child with hemophilia and high titer inhibitors to factor VIII: a case report and brief review. J Extra Corpor Technol 38:254–259PubMedGoogle Scholar
  319. 319.
    Turpie AG, Hirsh J, Gent M, Julian D, Johnson J (1989) Prevention of deep vein thrombosis in potential neurosurgical patients. A randomized trial comparing graduated compression stockings alone or graduated compression stockings plus intermittent pneumatic compression with control. Arch Intern Med 149:679–681PubMedGoogle Scholar
  320. 320.
    Ucar HI, Oc M, Tok M, Dogan OF, Oc B, Aydin A, Farsak B, Guvener M, Yorgancioglu AG, Dogan R, Demircin M, Pasaoglu I (2007) Preoperative fibrinogen levels as a predictor of postoperative bleeding after open heart surgery. Heart Surg Forum 10:E392–E396PubMedGoogle Scholar
  321. 321.
    Utter GH, Owings JT, Jacoby RC, Gosselin RC, Paglieroni TG (2002) Injury induces increased monocyte expression of tissue factor: factors associated with head injury attenuate the injury-related monocyte expression of tissue factor. J Trauma 52:1071–1077PubMedGoogle Scholar
  322. 322.
    van der Sande JJ, Veltkamp JJ, Boekhout-Mussert RJ, Bouwhuis-Hoogerwerf ML (1978) Head injury and coagulation disorders. J Neurosurg 49:357–365PubMedGoogle Scholar
  323. 323.
    Vavilala MS, Dunbar PJ, Rivara FP, Lam AM (2001) Coagulopathy predicts poor outcome following head injury in children less than 16 years of age. J Neurosurg Anesthesiol 13:13–18PubMedGoogle Scholar
  324. 324.
    Vecht CJ, Sibinga CT, Minderhoud JM (1975) Disseminated intravascular coagulation and head injury. J Neurol Neurosurg Psychiatry 38:567–571PubMedGoogle Scholar
  325. 325.
    Velik-Salchner C, Haas T, Innerhofer P, Streif W, Nussbaumer W, Klingler A, Klima G, Martinowitz U, Fries D (2007) The effect of fibrinogen concentrate on thrombocytopenia. J Thromb Haemost 5:1019–1025PubMedGoogle Scholar
  326. 326.
    Veshchev I, Elran H, Salame K (2002) Recombinant coagulation factor VIIa for rapid preoperative correction of warfarin-related coagulopathy in patients with acute subdural hematoma. Med Sci Monit 8:CS98–100PubMedGoogle Scholar
  327. 327.
    Vigue B, Ract C, Tremey B, Engrand N, Leblanc PE, Decaux A, Martin L, Benhamou D (2007) Ultra-rapid management of oral anticoagulant therapy-related surgical intracranial hemorrhage. Intensive Care Med 33:721–725PubMedGoogle Scholar
  328. 328.
    Wallis JP, Dzik S (2004) Is fresh-frozen plasma overtransfused in the United States? Transfusion 44:1674–1675PubMedGoogle Scholar
  329. 329.
    Weber AA, Adamzik M, Bachmann HS, Gorlinger K, Grandoch M, Leineweber K, Muller-Beissenhirtz H, Wenzel F, Naber C (2008) Methods to evaluate the pharmacology of oral antiplatelet drugs. Herz 33:287–296PubMedGoogle Scholar
  330. 330.
    Weber CF, Jambor C, Marquardt M, Gorlinger K, Zwissler B (2008) Thrombelastometric detection of factor XIII deficiency. Anaesthesist 57:487–490PubMedGoogle Scholar
  331. 331.
    Wen DY, Hall WA (1998) Complications of subcutaneous low-dose heparin therapy in neurosurgical patients. Surg Neurol 50:521–525PubMedGoogle Scholar
  332. 332.
    Wettstein P, Haeberli A, Stutz M, Rohner M, Corbetta C, Gabi K, Schnider T, Korte W (2004) Decreased factor XIII availability for thrombin and early loss of clot firmness in patients with unexplained intraoperative bleeding. Anesth Analg 99:1564–1569PubMedGoogle Scholar
  333. 333.
    Yamaki T, Hirakawa K, Ueguchi T, Tenjin H, Kuboyama T, Nakagawa Y (1990) Chronological evaluation of acute traumatic intracerebral haematoma. Acta Neurochir (Wien) 103:112–115Google Scholar
  334. 334.
    Yokota H, Naoe Y, Nakabayashi M, Unemoto K, Kushimoto S, Kurokawa A, Node Y, Yamamoto Y (2002) Cerebral endothelial injury in severe head injury: the significance of measurements of serum thrombomodulin and the von Willebrand factor. J Neurotrauma 19:1007–1015PubMedGoogle Scholar
  335. 335.
    Zetterling M, Ronne-Engstrom E (2004) High intraoperative blood loss may be a risk factor for postoperative hematoma. J Neurosurg Anesthesiol 16:151–155PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Ruediger Gerlach
    • 1
  • Manuela Krause
    • 2
  • Volker Seifert
    • 1
  • Klaus Goerlinger
    • 3
  1. 1.Department of NeurosurgeryJohann Wolfgang Goethe UniversityFrankfurt am MainGermany
  2. 2.Department of MedicineDKDWiesbadenGermany
  3. 3.Department of Anaesthesiology and Intensive Care MedicineUniversity EssenEssenGermany

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