Advertisement

Acta Neurochirurgica

, Volume 151, Issue 6, pp 569–574 | Cite as

Neurocytoma of the spinal cord: report of three cases and review of the literature

  • Filippo Maria Polli
  • Maurizio Salvati
  • Massimo Miscusi
  • Roberto Delfini
  • Felice Giangaspero
Review Article

Abstract

The spinal cord is a very rare location for extra-ventricular neurocytomas. Composed of small round cells with neuronal differentiation, neurocytoma has a particularly favourable prognosis. Long disease-free intervals have been observed in patients who received sub-total removal and radiotherapy. A careful intra-operative frozen section examination is helpful in avoiding excessive surgical tissue disturbance and to identify the best treatment option. To date, eight cases of neurocytoma of the spinal cord have been described. We report three more patients; one with very long survival, and review the published literature for this condition.

Keywords

Central nervous system Extraventricular neurocytoma Spinal cord tumour 

Notes

References

  1. 1.
    Brat DJ, Scheithauer BW, Eberhart CG, Burger PC (2001) Extra-ventricular neurocytomas: pathologic features and clinical outcome. Am J Surg Pathol 25:1252–1260PubMedCrossRefGoogle Scholar
  2. 2.
    Chang KH, Han MH, Kim DG, Chi JC, Suh DC, Kim SJ, Cha SH, Han MC (1993) MR appearance of central neurocytoma. Acta Radiol 34:520–526PubMedCrossRefGoogle Scholar
  3. 3.
    Coca S, Moreno M, Martos JA, Rodriguez J, Barcena A, Vaquero J (1994) Neurocytoma of spinal cord. Acta Neuropathol (Berl) 87:537–540CrossRefGoogle Scholar
  4. 4.
    Giangaspero F, Cenacchi G, Losi L, Cerasoli S, Bisceglia M, Burger PC (1997) Extra-ventricular neoplasms with neurocytoma features. A clinico-pathological study of 11 cases. Am J Surg Pathol 21:206–212PubMedCrossRefGoogle Scholar
  5. 5.
    Hassoun J, Gambarelli D, Grisoli F, Pellet W, Salamon G, Pellissier JF, Toga M (1982) Central neurocytoma: an electron microscopic study of two cases. Acta Neuropathol 56:151–156PubMedCrossRefGoogle Scholar
  6. 6.
    Hassoun J, Soylemezoglu F, Gambarelli D, Figarella-Branger D, von Ammon K, Kleihues P (1993) Central neurocytoma: a synopsis of clinical and histologic figures. Brain Pathol 3:297–306PubMedCrossRefGoogle Scholar
  7. 7.
    Jayasundar R, Shah T, Vaishya S, Singh VP, Sarkar C (2003) In vivo and in vitro MR spectroscopic profile of central neurocytomas. J Magn Reson Imaging 17:256–260PubMedCrossRefGoogle Scholar
  8. 8.
    Kim DG, Choe WJ, Chang KH, Song IC, Han MH, Jung HW, Cho BK (2000) In vivo proton magnetic resonance spectroscopy of central neurocytomas. Neurosurgery 46:329–333 discussion 333–334PubMedCrossRefGoogle Scholar
  9. 9.
    Kim DG, Paek SH, Kim IH, Chi JC, Jung HW, Han DH, Choi KS, Cho BK (1997) Central neurocytoma: the role of radiation therapy and long term outcome. Cancer 79:1995–2002PubMedCrossRefGoogle Scholar
  10. 10.
    Louis DN, Swearingen B, Linggood RM, Dickersin GR, Kretschmar C, Bhan AK, Hedley-Whyte ET (1990) Central nervous system neurocytoma and neuroblastoma in adults - report of eight cases. J Neurooncol 9:231–238PubMedCrossRefGoogle Scholar
  11. 11.
    Martin AJ, Sharr MM, Teddy PJ, Gardner BP, Robinson SF (2002) Neurocytoma of the thoracic spinal cord. Acta Neurochir (Wien) 144:823–828CrossRefGoogle Scholar
  12. 12.
    Miller DC, Kim R, Zagzag D (1992) Neurocytomas: non-classical sites and mixed elements. J Neuropathol Exp Neurol 51:364Google Scholar
  13. 13.
    Rades D, Fehlauer F (2002) Treatment options for central neurocytoma. Neurology 59:1268–1270PubMedGoogle Scholar
  14. 14.
    Schild SE, Scheithauer BW, Haddock MG, Schiff D, Burger PC, Wong WW, Lyons MK (1997) Central neurocytomas. Cancer 79:790–795PubMedCrossRefGoogle Scholar
  15. 15.
    Sharma MC, Deb P, Sharma S, Sarkar C (2006) Neurocytoma: a comprehensive review. Neurosurg Rev 29:270–285PubMedCrossRefGoogle Scholar
  16. 16.
    Sharma MC, Rathore A, Karak AK, Sarkar C (1998) A study of proliferative markers in central neurocytoma. Pathology 30:355–359PubMedCrossRefGoogle Scholar
  17. 17.
    Sharma S, Sarkar C, Gaikwad S, Suri A, Sharma MC (2005) Primary neurocytoma of the spinal cord: a case report and review of literature. J Neurooncol 74:47–52PubMedCrossRefGoogle Scholar
  18. 18.
    Singh A, Chand K, Singh H, Sarkar C, Sharma MC (2007) Atypical neurocytoma of the spinal cord in young child. Childs Nerv Syst 23:207–211PubMedCrossRefGoogle Scholar
  19. 19.
    Soylemezoglu F, Scheithauer BW, Esteve J, Kleihues P (1997) Atypical central neurocytoma. J Neuropathol Exp Neurol 56:551–556PubMedCrossRefGoogle Scholar
  20. 20.
    Stapleton SR, David KM, Harkness WF, Harding BN (1997) Central neurocytoma of the cervical spinal cord. J Neurol Neurosurg Psychiatry 63:119–120PubMedCrossRefGoogle Scholar
  21. 21.
    Stephan CL, Kepes JJ, Arnold P, Green KD, Chamberlin F (1999) Neurocytoma of the cauda equina. Case report. J Neurosurg 90(2 Suppl):247–251Google Scholar
  22. 22.
    Tatter SB, Borges LF, Louis DN (1994) Central neurocytomas of the cervical spinal cord. Report of two cases. J Neurosurg 81:288–293Google Scholar
  23. 23.
    Yasargil MG, von Ammon K, von Deimling A, Valavanis A, Wichmann W, Wiestler OD (1992) Central neurocytoma: histopathological variants and therapeutic approaches. J Neurosurg 76:32–37PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Filippo Maria Polli
    • 1
  • Maurizio Salvati
    • 2
  • Massimo Miscusi
    • 1
  • Roberto Delfini
    • 1
  • Felice Giangaspero
    • 2
    • 3
  1. 1.Neurosurgery, Department of NeurosciencesSapienza University of RomeRomaItaly
  2. 2.Department of NeurosurgeryIRCCS INM NeuromedPozzilliItaly
  3. 3.Department of Experimental pathologySapienza University of RomeRomeItaly

Personalised recommendations