Acta Neurochirurgica

, Volume 150, Issue 6, pp 613–615 | Cite as

Excellent response to letrozole in brain metastases from breast cancer

  • S. Goyal
  • T. Puri
  • P. K. Julka
  • G. K. Rath
Brief Report of a Special Case


Breast cancer with multiple parenchymal brain metastases carries an extremely poor outcome. Cranial radiotherapy improves survival by only a few months and the role of systemic therapy is marginal and largely unexplored. We report a patient with recurrent carcinoma of breast presenting with multiple bilateral cervical nodes and brain metastases manifesting as a right hemiparesis and facial nerve palsy, who was treated with palliative whole brain irradiation and letrozole. At the follow up at 20 months, neurological function had fully recovered, and both cerebral and extracerebral lesions had completely resolved, with calcification of the cerebral lesions. This report suggests that letrozole has beneficial effects both in extracranial and intracranial disease in hormone responsive metastatic breast cancer.

Keywords: Breast cancer; brain metastases; letrozole; radiotherapy. 


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Department of Radiotherapy and OncologyAll India Institute of Medical SciencesNew DelhiIndia

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