Acta Neurochirurgica

, 151:173

Isolated Whipple disease of the brain resembling a tumour

Brief Report of a Special Case



Isolated Whipple disease of the central nervous system is a rare occurrence. Migratory arthralgias and gastrointestinal problems, including malabsorption, abdominal pain, diarrhea, and weight loss, are common presenting symptoms.


For those patients with systemic signs and symptoms of Whipple disease, 6% to 43% will have clinically manifested CNS involvement that may include alterations in personality, ataxia, and dementia. We report our experience with a patient, who was successfully treated for Whipple disease 12 years prior to presentation and had a magnetic resonance image of the brain that revealed two solitary lesions resembling a tumor upon presentation.


Whipple disease Central nervous system Brain Whipple’s bacilli Tumour 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Brain Tumor Stem Cell Laboratory, Department of Neurosurgery and Oncology, The Johns Hopkins Neuro-Oncology Surgical Outcomes Research LaboratoryJohns Hopkins School of MedicineBaltimoreUSA

Personalised recommendations