Acta Neurochirurgica

, Volume 150, Issue 3, pp 265–271

Inhibitory effect of vasopressin receptor antagonist OPC-31260 on experimental brain oedema induced by global cerebral ischaemia

  • A. H. Molnár
  • C. Varga
  • A. Berkó
  • I. Rojik
  • A. Párducz
  • F. László
  • F. A. László
Experimental Research

DOI: 10.1007/s00701-007-1400-1

Cite this article as:
Molnár, A., Varga, C., Berkó, A. et al. Acta Neurochir (Wien) (2008) 150: 265. doi:10.1007/s00701-007-1400-1

Summary

The effects of the non-peptide vasopressin V2 receptor antagonist 5-dimethylamino-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine hydrochloride (OPC-31260) on the cerebral oedema induced by general cerebral hypoxia were studied in rats. The general cerebral hypoxia was produced by bilateral common carotid ligation in Sprague-Dawley rats of the CFY strain. By 6 h after the ligation, half of the rats had died, but the survival rate was significantly higher following OPC-31260 administration. Electron microscopic examinations revealed typical ischaemic changes after the carotid ligation. The carotid ligation increased the brain contents of water and Na+ and enhanced the plasma vasopressin level. The increased brain water and Na+ accumulation was prevented by OPC-31260 administration, but the plasma vasopressin level was further enhanced by OPC-31260. These results demonstrate the important role of vasopressin in the development of the disturbances in brain water and electrolyte balance in response to general cerebral hypoxia. The carotid ligation-induced cerebral oedema was significantly reduced following oral OPC-31260 administration. The protective mechanism exerted by OPC-31260 stems from its influence on the renal vasopressin V2 receptors. These observations might suggest an effective approach to the treatment of global hypoxia-induced cerebral oedema in humans.

Keywords: Carotid ligation; cerebral oedema; hyponatraemia; SIADH; vasopressin receptor antagonist; non-peptide. 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • A. H. Molnár
    • 1
    • 3
  • C. Varga
    • 1
  • A. Berkó
    • 1
  • I. Rojik
    • 1
  • A. Párducz
    • 2
  • F. László
    • 3
  • F. A. László
    • 1
  1. 1.Department of Comparative PhysiologyUniversity of SzegedSzegedHungary
  2. 2.Biological Research Centre, Laboratory of Molecular NeurobiologyHungarian Academy of SciencesSzegedHungary
  3. 3.Institute of Physical Education and Sport Sciences, Faculty of Juhász Gyula Teachers Training CollegeUniversity of SzegedSzegedHungary

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