Acta Neurochirurgica

, Volume 149, Issue 9, pp 897–902

Long-term follow-up of 5 patients with intracranial germinoma initially treated by chemotherapy alone

  • T. Ueba
  • K. Yamashita
  • I. Fujisawa
  • S. Nakao
  • K. Ooyama
  • T. Yorihuji
  • S. F. Kato
  • S. Seto
  • N. Kageyama
Clinical Article

DOI: 10.1007/s00701-007-1268-0

Cite this article as:
Ueba, T., Yamashita, K., Fujisawa, I. et al. Acta Neurochir (Wien) (2007) 149: 897. doi:10.1007/s00701-007-1268-0

Summary

Background. High rates of overall- and event-free survival have been reported in patients with intracranial germinoma treated by radiotherapy. We report the long-term results after treatment initially with chemotherapy, but without radiation.

Patients and method. Five patients with an intracranial germinoma were treated with 2 cycles of etoposide and cisplatin, without radiotherapy. All achieved complete remission; 3 suffered recurrence within 2 years and were again treated with 2 cycles of etoposide and cisplatin followed by radiotherapy.

Results. At long-term follow-up, each of the 5 patients was in complete remission without further recurrence. Each patient with a neurohypophyseal germinoma who presented with endocrinopathy had initially recovered endocrinological function.

Conclusion. In a patient with a germinoma chemotherapy, and restriction of radiation to those with recurrence may allow restoration of hypophyseal function damaged by the intracranial germinoma without compromising long term survivial.

Keywords: Intracranial germinoma; neurohypophyseal; chemotherapy; endocrinopathy. 

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • T. Ueba
    • 1
  • K. Yamashita
    • 1
  • I. Fujisawa
    • 2
  • S. Nakao
    • 1
  • K. Ooyama
    • 1
  • T. Yorihuji
    • 3
  • S. F. Kato
    • 4
  • S. Seto
    • 3
  • N. Kageyama
    • 1
  1. 1.Department of NeurosurgeryKisiwada City HospitalOsakaJapan
  2. 2.Department of RadiologyKisiwada City HospitalOsakaJapan
  3. 3.Department of PaediatricsKisiwada City HospitalOsakaJapan
  4. 4.Department of EndocrinologyKisiwada City HospitalOsakaJapan

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