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Microchimica Acta

, Volume 140, Issue 1–2, pp 93–96 | Cite as

Construction and Evaluation of a Promazinium Cation-Selective Electrode

  • Magda M. Ayad
  • Abdalla Shalaby
  • Hisham E. Abdellatef
  • Heba M. Elsaid

Abstract.

 The construction of a plasticised PVC matrix-type promazinium cation-selective membrane electrode and its use in the potentiometric determination of promazine hydrochloride in pharmaceutical preparations are described. It is based on the use of the ion-associate species, formed by promazinium cation and tetraphenylborate (TPB) counter ion. The basic electrode performance characteristics are evaluated according to IUPAC recommendations. It exhibited a linear response for 1 × 10−2−1 × 10−5 M of promazine hydrochloride solutions with a cationic Nernstian slope over the pH range 2–6. Common organic and inorganic cations showed negligible interference. Direct potentiometric determination of 1 × 10−2−1 × 10−5 M aqueous promazine hydrochloride using this membrane electrode system showed an average recovery of 99.5% with a mean standard deviation of 1.5%. This electrode was successfully used for monitoring the titration of promazine hydrochloride with sodium tetraphenyl borate and for determining promazine hydrochloride in ampoules.

Key words: Promazine hydrochloride; ion-selective electrode; tetraphenylborate; potentiometric titration; pharmaceutical analysis. 

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Copyright information

© Springer-Verlag Wien 2002

Authors and Affiliations

  • Magda M. Ayad
    • 1
  • Abdalla Shalaby
    • 1
  • Hisham E. Abdellatef
    • 1
  • Heba M. Elsaid
    • 1
  1. 1.Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, EgyptEG

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